ENSG00000198075

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272452 ENSG00000198075 HEK293_OSMI2_2hA HEK293_TMG_2hB SULT1C4 protein_coding protein_coding 1.680003 1.936777 1.6543 0.1576756 0.07665792 -0.2261726 0.6239289 0.66238440 0.5712785 0.1586304 0.05181779 -0.2100566 0.37437083 0.33600000 0.3494333 0.01343333 0.98554760 0.03619178 FALSE  
ENST00000409309 ENSG00000198075 HEK293_OSMI2_2hA HEK293_TMG_2hB SULT1C4 protein_coding protein_coding 1.680003 1.936777 1.6543 0.1576756 0.07665792 -0.2261726 0.9138349 1.22869985 0.8918254 0.1042847 0.08846416 -0.4579066 0.53513750 0.64116667 0.5364000 -0.10476667 0.59807193 0.03619178 FALSE  
ENST00000494122 ENSG00000198075 HEK293_OSMI2_2hA HEK293_TMG_2hB SULT1C4 protein_coding retained_intron 1.680003 1.936777 1.6543 0.1576756 0.07665792 -0.2261726 0.1422393 0.04569286 0.1911956 0.0177944 0.03854731 1.8530346 0.09049167 0.02283333 0.1141667 0.09133333 0.03619178 0.03619178 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198075 E001 0.3634088 0.264025400 0.3464420871   2 108377911 108377953 43 + 0.001 0.204 8.909
ENSG00000198075 E002 10.2980034 0.029414159 0.8190213311 0.885698742 2 108377954 108378184 231 + 1.039 1.049 0.039
ENSG00000198075 E003 24.1722654 0.008898444 0.1477254877 0.258599457 2 108378185 108378506 322 + 1.435 1.364 -0.246
ENSG00000198075 E004 14.6509926 0.001350883 0.0331696991 0.078143381 2 108381762 108381887 126 + 1.264 1.122 -0.504
ENSG00000198075 E005 1.4843710 0.009376399 0.0021535483 0.007700267 2 108381888 108382384 497 + 0.622 0.113 -3.418
ENSG00000198075 E006 1.9584945 0.007542395 0.3108333330 0.453275980 2 108382385 108382482 98 + 0.542 0.397 -0.732
ENSG00000198075 E007 0.8211642 0.018365795 0.1013195806 0.192480076 2 108382483 108382922 440 + 0.384 0.114 -2.246
ENSG00000198075 E008 3.4863152 0.028332264 0.7257077422 0.818927310 2 108383093 108383219 127 + 0.657 0.633 -0.105
ENSG00000198075 E009 13.9679429 0.020343604 0.3408891495 0.484816200 2 108383416 108383510 95 + 1.211 1.147 -0.228
ENSG00000198075 E010 16.7865854 0.012707311 0.4121244028 0.555672363 2 108386192 108386372 181 + 1.273 1.238 -0.123
ENSG00000198075 E011 77.6085042 0.013649467 0.0006915433 0.002868452 2 108387320 108388989 1670 + 1.774 1.956 0.611