ENSG00000198055

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355472 ENSG00000198055 HEK293_OSMI2_2hA HEK293_TMG_2hB GRK6 protein_coding protein_coding 110.5126 182.0054 67.4651 11.48927 0.5571736 -1.431633 23.369685 38.07957 19.63579 5.565306 0.7418356 -0.9551756 0.20253333 0.20933333 0.29110000 0.08176667 1.572066e-01 1.195006e-28 FALSE  
ENST00000355958 ENSG00000198055 HEK293_OSMI2_2hA HEK293_TMG_2hB GRK6 protein_coding protein_coding 110.5126 182.0054 67.4651 11.48927 0.5571736 -1.431633 29.954872 48.90368 16.94066 5.717534 0.7379789 -1.5288964 0.28002500 0.26676667 0.25123333 -0.01553333 8.219281e-01 1.195006e-28 FALSE  
ENST00000507633 ENSG00000198055 HEK293_OSMI2_2hA HEK293_TMG_2hB GRK6 protein_coding protein_coding 110.5126 182.0054 67.4651 11.48927 0.5571736 -1.431633 17.193150 26.85400 12.81947 2.919512 1.1274281 -1.0662129 0.15300000 0.14693333 0.19030000 0.04336667 2.990087e-01 1.195006e-28 FALSE  
ENST00000508705 ENSG00000198055 HEK293_OSMI2_2hA HEK293_TMG_2hB GRK6 protein_coding nonsense_mediated_decay 110.5126 182.0054 67.4651 11.48927 0.5571736 -1.431633 16.230838 24.25616 5.71064 1.700353 2.8958172 -2.0846971 0.14880833 0.13440000 0.08426667 -0.05013333 7.730817e-01 1.195006e-28 FALSE  
ENST00000528793 ENSG00000198055 HEK293_OSMI2_2hA HEK293_TMG_2hB GRK6 protein_coding protein_coding 110.5126 182.0054 67.4651 11.48927 0.5571736 -1.431633 7.243515 15.47700 0.00000 1.679468 0.0000000 -10.5968420 0.05959167 0.08663333 0.00000000 -0.08663333 1.195006e-28 1.195006e-28 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198055 E001 0.2214452 3.816526e-02 1.000000e+00   5 177403204 177403526 323 + 0.000 0.074 8.718
ENSG00000198055 E002 0.5503986 2.030902e-02 7.531414e-01 8.391778e-01 5 177404194 177404389 196 + 0.195 0.138 -0.607
ENSG00000198055 E003 0.2214452 3.816526e-02 1.000000e+00   5 177404390 177404405 16 + 0.000 0.074 10.762
ENSG00000198055 E004 1.4350612 1.010493e-02 9.728290e-01 9.870343e-01 5 177404406 177404557 152 + 0.330 0.326 -0.023
ENSG00000198055 E005 0.6287620 1.809177e-02 2.990812e-01 4.405672e-01 5 177411764 177411789 26 + 0.330 0.137 -1.611
ENSG00000198055 E006 0.3634088 3.915652e-01 8.229130e-01   5 177413971 177414042 72 + 0.000 0.138 10.650
ENSG00000198055 E007 1.9884800 1.265691e-02 4.725660e-01 6.116300e-01 5 177426496 177426619 124 + 0.330 0.456 0.709
ENSG00000198055 E008 0.0000000       5 177426676 177426681 6 +      
ENSG00000198055 E009 0.0000000       5 177426682 177426683 2 +      
ENSG00000198055 E010 43.5038940 1.644349e-02 3.065053e-60 3.088644e-57 5 177426684 177426744 61 + 2.196 0.601 -5.705
ENSG00000198055 E011 44.4690875 1.487243e-02 1.439418e-65 1.782310e-62 5 177426745 177426749 5 + 2.208 0.580 -5.841
ENSG00000198055 E012 47.1799649 9.018959e-03 1.398415e-85 2.911269e-82 5 177426750 177426751 2 + 2.234 0.600 -5.834
ENSG00000198055 E013 95.5202861 2.468217e-02 3.710453e-23 3.347306e-21 5 177426752 177426793 42 + 2.394 1.522 -2.936
ENSG00000198055 E014 143.6740446 2.795797e-02 1.430849e-07 1.411015e-06 5 177426794 177426842 49 + 2.386 1.926 -1.539
ENSG00000198055 E015 137.9729378 1.236597e-02 9.796448e-10 1.455614e-08 5 177426843 177426853 11 + 2.327 1.936 -1.310
ENSG00000198055 E016 269.8346063 1.057544e-02 4.819261e-08 5.215920e-07 5 177426854 177426897 44 + 2.568 2.257 -1.036
ENSG00000198055 E017 1.7305929 8.218092e-03 8.772747e-03 2.571516e-02 5 177427120 177427149 30 + 0.697 0.242 -2.417
ENSG00000198055 E018 14.4761389 7.880071e-03 2.520933e-05 1.527045e-04 5 177430676 177430871 196 + 1.396 0.966 -1.535
ENSG00000198055 E019 535.3521168 4.918392e-03 2.827509e-04 1.309497e-03 5 177430872 177430967 96 + 2.754 2.605 -0.495
ENSG00000198055 E020 10.9221054 1.672145e-03 1.923415e-02 4.984204e-02 5 177431711 177431994 284 + 1.182 0.918 -0.967
ENSG00000198055 E021 650.8823447 2.346805e-03 8.503377e-01 9.071575e-01 5 177431995 177432107 113 + 2.740 2.721 -0.063
ENSG00000198055 E022 787.9264072 1.352181e-03 6.170245e-01 7.349200e-01 5 177432233 177432310 78 + 2.810 2.807 -0.011
ENSG00000198055 E023 849.9441926 4.119823e-04 2.488694e-01 3.846035e-01 5 177432706 177432806 101 + 2.868 2.832 -0.122
ENSG00000198055 E024 1045.1505446 1.095169e-03 9.484359e-02 1.826500e-01 5 177433147 177433239 93 + 2.968 2.920 -0.160
ENSG00000198055 E025 522.3072372 1.525258e-03 7.123034e-02 1.453822e-01 5 177433347 177433350 4 + 2.676 2.615 -0.205
ENSG00000198055 E026 846.9002630 9.834657e-04 2.115207e-01 3.402908e-01 5 177433351 177433410 60 + 2.871 2.830 -0.136
ENSG00000198055 E027 1276.5734390 9.297297e-05 3.491394e-02 8.149154e-02 5 177433536 177433669 134 + 3.009 3.017 0.025
ENSG00000198055 E028 545.5308572 1.209433e-03 1.839118e-03 6.723829e-03 5 177433670 177433676 7 + 2.601 2.662 0.203
ENSG00000198055 E029 1085.0098261 1.393560e-03 2.304223e-01 3.629629e-01 5 177433914 177434015 102 + 2.940 2.951 0.036
ENSG00000198055 E030 1035.7497189 8.308532e-04 3.415715e-01 4.854768e-01 5 177434016 177434104 89 + 2.926 2.928 0.006
ENSG00000198055 E031 828.8194134 7.601475e-04 6.763964e-01 7.813788e-01 5 177434902 177434939 38 + 2.850 2.825 -0.081
ENSG00000198055 E032 1108.9846937 2.258898e-04 5.144265e-02 1.117169e-01 5 177435032 177435121 90 + 2.948 2.958 0.033
ENSG00000198055 E033 1603.1946579 2.415811e-04 7.821195e-09 9.830173e-08 5 177436073 177436281 209 + 3.072 3.127 0.184
ENSG00000198055 E034 1229.8220206 1.888552e-04 1.437518e-13 3.994917e-12 5 177436393 177436530 138 + 2.934 3.017 0.276
ENSG00000198055 E035 59.4985623 6.928760e-04 1.178874e-04 6.041608e-04 5 177436531 177436685 155 + 1.524 1.735 0.717
ENSG00000198055 E036 1107.8203070 3.942709e-04 9.722226e-07 8.086432e-06 5 177440700 177440837 138 + 2.908 2.968 0.199
ENSG00000198055 E037 13.0082855 3.023101e-02 4.748760e-01 6.136729e-01 5 177440916 177440918 3 + 1.148 1.038 -0.399
ENSG00000198055 E038 982.5503188 2.459669e-04 4.233541e-07 3.799657e-06 5 177440919 177441053 135 + 2.856 2.916 0.198
ENSG00000198055 E039 23.2122464 1.082868e-03 3.104777e-03 1.057441e-02 5 177441245 177441450 206 + 1.477 1.231 -0.855
ENSG00000198055 E040 75.2269955 3.537487e-04 1.533934e-01 2.662897e-01 5 177441735 177441736 2 + 1.749 1.801 0.175
ENSG00000198055 E041 2203.4897587 1.483266e-03 4.157752e-10 6.608000e-09 5 177441737 177443267 1531 + 3.171 3.277 0.353