ENSG00000198040

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000438628 ENSG00000198040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF84 protein_coding protein_coding 4.444249 2.386231 7.651182 0.3484389 0.3039019 1.6768 0.6492421 0.674383602 2.3089108 0.368879887 0.23882568 1.760570 0.14185833 0.245833333 0.30506667 0.05923333 8.231668e-01 6.322883e-05   FALSE
ENST00000535439 ENSG00000198040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF84 protein_coding protein_coding 4.444249 2.386231 7.651182 0.3484389 0.3039019 1.6768 0.3280289 0.704235437 0.1146132 0.234798170 0.05794044 -2.518943 0.11439167 0.284166667 0.01480000 -0.26936667 6.322883e-05 6.322883e-05 FALSE TRUE
ENST00000536123 ENSG00000198040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF84 protein_coding protein_coding 4.444249 2.386231 7.651182 0.3484389 0.3039019 1.6768 0.6397865 0.138439299 1.1240983 0.138439299 0.67833923 2.933601 0.10303750 0.081866667 0.14116667 0.05930000 6.873610e-01 6.322883e-05   FALSE
ENST00000539354 ENSG00000198040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF84 protein_coding protein_coding 4.444249 2.386231 7.651182 0.3484389 0.3039019 1.6768 1.1041900 0.508767230 1.2786315 0.105691129 0.24098430 1.312680 0.27970417 0.239166667 0.16663333 -0.07253333 7.714182e-01 6.322883e-05 FALSE TRUE
ENST00000542358 ENSG00000198040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF84 protein_coding retained_intron 4.444249 2.386231 7.651182 0.3484389 0.3039019 1.6768 0.3303693 0.071058696 0.6109380 0.021248276 0.02696672 2.937410 0.07090833 0.028133333 0.08006667 0.05193333 1.115946e-01 6.322883e-05   FALSE
ENST00000543310 ENSG00000198040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF84 protein_coding protein_coding 4.444249 2.386231 7.651182 0.3484389 0.3039019 1.6768 0.3838167 0.000000000 0.3111293 0.000000000 0.31112934 5.005083 0.07343333 0.000000000 0.04243333 0.04243333 1.000000e+00 6.322883e-05   FALSE
MSTRG.8368.9 ENSG00000198040 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF84 protein_coding   4.444249 2.386231 7.651182 0.3484389 0.3039019 1.6768 0.2074201 0.009226367 0.7879580 0.009226367 0.25959970 5.375155 0.03866250 0.003433333 0.10170000 0.09826667 8.717738e-03 6.322883e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198040 E001 0.2998086 0.0286536999 3.724382e-01   12 133037292 133037300 9 + 0.070 0.204 1.768
ENSG00000198040 E002 0.4470576 0.0229070713 6.612470e-01 7.697347e-01 12 133037301 133037310 10 + 0.131 0.204 0.769
ENSG00000198040 E003 2.0940903 0.0087851449 5.095411e-01 6.448514e-01 12 133037311 133037393 83 + 0.412 0.532 0.603
ENSG00000198040 E004 4.6247439 0.1288159809 8.547400e-01 9.101472e-01 12 133037394 133037478 85 + 0.687 0.726 0.162
ENSG00000198040 E005 4.0054571 0.0058821702 2.940140e-01 4.350889e-01 12 133037479 133037502 24 + 0.601 0.764 0.685
ENSG00000198040 E006 3.2399534 0.0048271770 8.766056e-02 1.715780e-01 12 133037503 133037508 6 + 0.493 0.764 1.187
ENSG00000198040 E007 6.0937963 0.0031913020 8.971220e-02 1.746894e-01 12 133037509 133037524 16 + 0.718 0.946 0.888
ENSG00000198040 E008 7.0192465 0.0025028647 7.223538e-02 1.470548e-01 12 133037525 133037529 5 + 0.773 1.001 0.872
ENSG00000198040 E009 11.6390600 0.0016219420 3.531069e-01 4.973535e-01 12 133037530 133037545 16 + 1.014 1.115 0.366
ENSG00000198040 E010 2.7753949 0.0054422893 5.282887e-01 6.612025e-01 12 133037546 133037554 9 + 0.561 0.448 -0.551
ENSG00000198040 E011 2.8775794 0.0053519242 1.701039e-01 2.883230e-01 12 133037580 133037969 390 + 0.601 0.343 -1.316
ENSG00000198040 E012 4.0966964 0.0041636405 3.548325e-01 4.991643e-01 12 133038875 133038887 13 + 0.688 0.532 -0.687
ENSG00000198040 E013 7.5518711 0.0185620956 1.788475e-01 2.996944e-01 12 133038888 133039012 125 + 0.924 0.718 -0.808
ENSG00000198040 E014 1.4944876 0.2878022426 4.798628e-01 6.182018e-01 12 133039013 133039047 35 + 0.411 0.205 -1.385
ENSG00000198040 E015 9.9450080 0.0016940537 1.079158e-02 3.066634e-02 12 133040434 133041099 666 + 1.057 0.717 -1.304
ENSG00000198040 E016 7.5773922 0.0339146382 5.103622e-01 6.455963e-01 12 133041100 133041277 178 + 0.906 0.807 -0.384
ENSG00000198040 E017 16.4380532 0.0013607864 6.599029e-01 7.686425e-01 12 133041278 133041284 7 + 1.194 1.153 -0.144
ENSG00000198040 E018 45.0205643 0.0006099535 1.547551e-01 2.680958e-01 12 133041285 133041482 198 + 1.588 1.669 0.277
ENSG00000198040 E019 0.2214452 0.0371590381 1.313785e-01   12 133041483 133041485 3 + 0.000 0.205 11.389
ENSG00000198040 E020 0.1472490 0.0429211605 1.000000e+00   12 133047621 133047929 309 + 0.070 0.000 -9.745
ENSG00000198040 E021 0.1472490 0.0429211605 1.000000e+00   12 133047930 133047954 25 + 0.070 0.000 -9.745
ENSG00000198040 E022 35.3490687 0.0007144416 7.960092e-02 1.589108e-01 12 133047955 133048081 127 + 1.478 1.589 0.381
ENSG00000198040 E023 2.9894677 0.0052619495 1.406341e-01 2.488880e-01 12 133048082 133048752 671 + 0.620 0.343 -1.399
ENSG00000198040 E024 26.0855368 0.0008080579 6.357826e-01 7.499732e-01 12 133048753 133048848 96 + 1.372 1.409 0.128
ENSG00000198040 E025 0.4502799 0.0261985800 5.025316e-01 6.385827e-01 12 133050524 133050586 63 + 0.184 0.000 -11.315
ENSG00000198040 E026 11.4366627 0.0017022536 1.487306e-01 2.599602e-01 12 133056954 133056956 3 + 1.083 0.915 -0.622
ENSG00000198040 E027 293.9231377 0.0003568687 3.931825e-03 1.295092e-02 12 133056957 133063078 6122 + 2.424 2.378 -0.153
ENSG00000198040 E028 8.4663695 0.0288550648 1.434342e-07 1.413944e-06 12 133063079 133063304 226 + 0.620 1.316 2.636