ENSG00000198039

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395375 ENSG00000198039 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF273 protein_coding nonsense_mediated_decay 4.071177 1.715387 6.871567 0.2475171 0.3392004 1.995817 0.2943271 0.18930553 0.7294914 0.18930553 0.46347354 1.891552 0.07015833 0.1141333 0.10926667 -0.004866667 8.009380e-01 2.081033e-21 FALSE TRUE
ENST00000476120 ENSG00000198039 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF273 protein_coding protein_coding 4.071177 1.715387 6.871567 0.2475171 0.3392004 1.995817 1.4653043 0.23702373 2.4529094 0.15969397 0.44932665 3.317642 0.32693750 0.1261333 0.35420000 0.228066667 2.259108e-01 2.081033e-21 FALSE TRUE
MSTRG.29921.10 ENSG00000198039 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF273 protein_coding   4.071177 1.715387 6.871567 0.2475171 0.3392004 1.995817 0.3670233 0.00000000 0.9571024 0.00000000 0.20790630 6.595597 0.05433750 0.0000000 0.13970000 0.139700000 4.269062e-05 2.081033e-21   FALSE
MSTRG.29921.5 ENSG00000198039 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF273 protein_coding   4.071177 1.715387 6.871567 0.2475171 0.3392004 1.995817 0.8127322 1.05920690 0.6553895 0.15604061 0.02867791 -0.684270 0.34005833 0.6172667 0.09626667 -0.521000000 2.081033e-21 2.081033e-21 FALSE TRUE
MSTRG.29921.8 ENSG00000198039 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF273 protein_coding   4.071177 1.715387 6.871567 0.2475171 0.3392004 1.995817 0.2712948 0.08744949 0.6619637 0.08744949 0.10926647 2.785657 0.04460833 0.0403000 0.09550000 0.055200000 4.609367e-01 2.081033e-21   FALSE
MSTRG.29921.9 ENSG00000198039 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF273 protein_coding   4.071177 1.715387 6.871567 0.2475171 0.3392004 1.995817 0.8233365 0.08936283 1.3908881 0.08936283 0.29931770 3.817492 0.14275417 0.0678000 0.20146667 0.133666667 2.411377e-01 2.081033e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198039 E001 0.0000000       7 64870172 64870381 210 +      
ENSG00000198039 E002 0.0000000       7 64877660 64877874 215 +      
ENSG00000198039 E003 0.0000000       7 64878381 64878495 115 +      
ENSG00000198039 E004 0.0000000       7 64879450 64880239 790 +      
ENSG00000198039 E005 0.0000000       7 64882493 64882512 20 +      
ENSG00000198039 E006 0.0000000       7 64882513 64882785 273 +      
ENSG00000198039 E007 0.0000000       7 64888573 64889855 1283 +      
ENSG00000198039 E008 0.0000000       7 64893412 64893456 45 +      
ENSG00000198039 E009 0.0000000       7 64893748 64893897 150 +      
ENSG00000198039 E010 0.1515154 0.0452677160 1.000000e+00   7 64897348 64898054 707 + 0.067 0.001 -7.070
ENSG00000198039 E011 0.4407149 0.0211999795 5.945860e-01 7.167882e-01 7 64903235 64903252 18 + 0.125 0.214 0.936
ENSG00000198039 E012 2.0961812 0.0071355099 9.583961e-01 9.779179e-01 7 64903253 64903272 20 + 0.452 0.464 0.062
ENSG00000198039 E013 2.0961812 0.0071355099 9.583961e-01 9.779179e-01 7 64903273 64903276 4 + 0.452 0.464 0.062
ENSG00000198039 E014 4.4264930 0.0037501190 6.704770e-01 7.768894e-01 7 64903277 64903287 11 + 0.668 0.737 0.285
ENSG00000198039 E015 19.3327691 0.0010715620 6.253864e-02 1.309173e-01 7 64903288 64903366 79 + 1.208 1.367 0.558
ENSG00000198039 E016 22.2733944 0.0010112702 4.519055e-02 1.005451e-01 7 64903367 64903419 53 + 1.262 1.423 0.558
ENSG00000198039 E017 11.3542222 0.0016065956 1.020374e-01 1.936225e-01 7 64917030 64917118 89 + 1.066 0.867 -0.740
ENSG00000198039 E018 31.8896664 0.0008021709 4.545039e-04 1.984567e-03 7 64917581 64917707 127 + 1.394 1.620 0.776
ENSG00000198039 E019 25.7694501 0.0011852760 1.176905e-02 3.298165e-02 7 64918197 64918292 96 + 1.314 1.499 0.639
ENSG00000198039 E020 30.7351245 0.0006717401 8.170027e-26 9.643534e-24 7 64923386 64924431 1046 + 1.189 1.823 2.180
ENSG00000198039 E021 105.1276610 0.0003520272 5.722314e-20 3.613612e-18 7 64927654 64929024 1371 + 2.025 1.640 -1.298
ENSG00000198039 E022 81.8733195 0.0005055254 3.434826e-05 2.012860e-04 7 64929025 64930981 1957 + 1.887 1.705 -0.616
ENSG00000198039 E023 1.5209027 0.0089915160 9.492145e-01 9.721787e-01 7 64942499 64942614 116 + 0.367 0.357 -0.063