ENSG00000198001

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000440781 ENSG00000198001 HEK293_OSMI2_2hA HEK293_TMG_2hB IRAK4 protein_coding protein_coding 3.232199 1.302543 4.541965 0.2225319 0.5601315 1.794125 0.08170106 0.29474784 0.00000000 0.29474784 0.00000000 -4.9295441 0.07454583 0.22813333 0.000000000 -0.22813333 0.6551924 0.046144 FALSE TRUE
ENST00000547521 ENSG00000198001 HEK293_OSMI2_2hA HEK293_TMG_2hB IRAK4 protein_coding nonsense_mediated_decay 3.232199 1.302543 4.541965 0.2225319 0.5601315 1.794125 0.26101433 0.12353684 0.18007064 0.06686538 0.04088634 0.5092979 0.08033333 0.11936667 0.043233333 -0.07613333 0.7695026 0.046144 FALSE TRUE
ENST00000547928 ENSG00000198001 HEK293_OSMI2_2hA HEK293_TMG_2hB IRAK4 protein_coding retained_intron 3.232199 1.302543 4.541965 0.2225319 0.5601315 1.794125 0.47042717 0.17052805 0.49571004 0.05463395 0.07296850 1.4860874 0.12167917 0.12830000 0.109166667 -0.01913333 0.7958502 0.046144 FALSE FALSE
ENST00000550615 ENSG00000198001 HEK293_OSMI2_2hA HEK293_TMG_2hB IRAK4 protein_coding nonsense_mediated_decay 3.232199 1.302543 4.541965 0.2225319 0.5601315 1.794125 0.30449309 0.11310612 0.19888191 0.11310612 0.19888191 0.7627850 0.10727500 0.06680000 0.055933333 -0.01086667 0.8347605 0.046144 FALSE TRUE
ENST00000551736 ENSG00000198001 HEK293_OSMI2_2hA HEK293_TMG_2hB IRAK4 protein_coding protein_coding 3.232199 1.302543 4.541965 0.2225319 0.5601315 1.794125 0.23876362 0.00000000 0.36739986 0.00000000 0.13683873 5.2380220 0.06217917 0.00000000 0.088300000 0.08830000 0.0461440 0.046144 FALSE TRUE
ENST00000552309 ENSG00000198001 HEK293_OSMI2_2hA HEK293_TMG_2hB IRAK4 protein_coding nonsense_mediated_decay 3.232199 1.302543 4.541965 0.2225319 0.5601315 1.794125 0.19876245 0.07099154 0.59606667 0.03722776 0.31869184 2.9036334 0.04888750 0.04726667 0.121733333 0.07446667 0.8583844 0.046144 FALSE FALSE
ENST00000613694 ENSG00000198001 HEK293_OSMI2_2hA HEK293_TMG_2hB IRAK4 protein_coding protein_coding 3.232199 1.302543 4.541965 0.2225319 0.5601315 1.794125 1.04814570 0.34742616 1.84223197 0.14324650 0.27379841 2.3735476 0.29075417 0.30253333 0.405100000 0.10256667 0.7193033 0.046144 FALSE TRUE
ENST00000696790 ENSG00000198001 HEK293_OSMI2_2hA HEK293_TMG_2hB IRAK4 protein_coding nonsense_mediated_decay 3.232199 1.302543 4.541965 0.2225319 0.5601315 1.794125 0.13899457 0.00000000 0.29400586 0.00000000 0.29400586 4.9260272 0.02259167 0.00000000 0.053500000 0.05350000 1.0000000 0.046144 FALSE TRUE
ENST00000696792 ENSG00000198001 HEK293_OSMI2_2hA HEK293_TMG_2hB IRAK4 protein_coding nonsense_mediated_decay 3.232199 1.302543 4.541965 0.2225319 0.5601315 1.794125 0.09089703 0.16442562 0.03056059 0.16442562 0.03056059 -2.1044615 0.05965417 0.09710000 0.006666667 -0.09043333 0.7025767 0.046144 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198001 E001 0.1515154 0.045150816 1.0000000000   12 43758944 43758949 6 + 0.072 0.000 -9.179
ENSG00000198001 E002 0.0000000       12 43758950 43758950 1 +      
ENSG00000198001 E003 0.1515154 0.045150816 1.0000000000   12 43758951 43758960 10 + 0.072 0.000 -11.014
ENSG00000198001 E004 0.4482035 0.036115561 0.4544733542 0.5951215390 12 43758961 43758966 6 + 0.188 0.000 -12.488
ENSG00000198001 E005 0.7406253 0.015666264 0.1970630102 0.3225480034 12 43758967 43758971 5 + 0.280 0.000 -13.183
ENSG00000198001 E006 2.5173042 0.006081439 0.0392318147 0.0896111598 12 43758972 43758990 19 + 0.591 0.200 -2.308
ENSG00000198001 E007 4.2864946 0.063655538 0.0849475572 0.1673240507 12 43758991 43759016 26 + 0.756 0.437 -1.438
ENSG00000198001 E008 0.5911862 0.018511870 0.2929904835 0.4340318890 12 43759017 43759035 19 + 0.237 0.000 -12.909
ENSG00000198001 E009 1.7444242 0.010421344 0.8544545297 0.9099557445 12 43759036 43759200 165 + 0.389 0.440 0.277
ENSG00000198001 E010 2.4348092 0.240491407 0.1390365224 0.2467590877 12 43759201 43759592 392 + 0.356 0.722 1.748
ENSG00000198001 E011 0.5985731 0.024256018 1.0000000000 1.0000000000 12 43760242 43760924 683 + 0.188 0.200 0.105
ENSG00000198001 E012 1.6273536 0.008422974 0.1849004041 0.3073593835 12 43760925 43760972 48 + 0.449 0.200 -1.630
ENSG00000198001 E013 0.0000000       12 43761572 43761810 239 +      
ENSG00000198001 E014 0.0000000       12 43763302 43763456 155 +      
ENSG00000198001 E015 5.3344171 0.009051075 0.0120536064 0.0336613634 12 43768103 43768104 2 + 0.844 0.440 -1.770
ENSG00000198001 E016 14.8863129 0.001350883 0.0177802782 0.0466630700 12 43768105 43768272 168 + 1.210 0.990 -0.794
ENSG00000198001 E017 1.4685651 0.027305083 0.0379993159 0.0873509811 12 43768273 43768592 320 + 0.449 0.000 -13.915
ENSG00000198001 E018 1.0330470 0.011871649 0.0948783989 0.1827041477 12 43771038 43771046 9 + 0.355 0.000 -13.578
ENSG00000198001 E019 1.3360778 0.009752367 0.0476248760 0.1049542242 12 43771047 43771104 58 + 0.420 0.000 -13.857
ENSG00000198001 E020 11.3457421 0.001836327 0.0310340470 0.0739814659 12 43771220 43771365 146 + 1.100 0.871 -0.849
ENSG00000198001 E021 23.6252832 0.001119062 0.0412180721 0.0932809320 12 43772180 43772362 183 + 1.380 1.240 -0.489
ENSG00000198001 E022 14.6264329 0.001186160 0.0059057314 0.0183624340 12 43772912 43772986 75 + 1.205 0.935 -0.982
ENSG00000198001 E023 14.0738522 0.001267523 0.1584275223 0.2730297906 12 43772987 43773072 86 + 1.158 1.039 -0.429
ENSG00000198001 E024 2.4679959 0.006381395 0.5681731935 0.6948601870 12 43773795 43773964 170 + 0.476 0.594 0.554
ENSG00000198001 E025 12.5317658 0.001725370 0.5833444495 0.7074724465 12 43773965 43774029 65 + 1.061 1.142 0.294
ENSG00000198001 E026 13.4915365 0.001763403 0.4711597452 0.6103109014 12 43777630 43777744 115 + 1.130 1.083 -0.169
ENSG00000198001 E027 14.6267665 0.005361876 0.2859081189 0.4262734459 12 43778193 43778302 110 + 1.169 1.083 -0.307
ENSG00000198001 E028 20.8198065 0.001642887 0.6575737213 0.7668913753 12 43782307 43782490 184 + 1.293 1.282 -0.039
ENSG00000198001 E029 11.8738826 0.002078769 0.2514709252 0.3877188188 12 43783662 43783724 63 + 1.018 1.160 0.516
ENSG00000198001 E030 8.2483808 0.037072406 0.3160762189 0.4588376623 12 43786399 43786402 4 + 0.865 1.020 0.583
ENSG00000198001 E031 15.2715554 0.001350883 0.2280164522 0.3600604388 12 43786403 43786557 155 + 1.118 1.255 0.485
ENSG00000198001 E032 142.0663343 0.007072560 0.0000923768 0.0004861657 12 43786680 43789869 3190 + 2.057 2.220 0.545
ENSG00000198001 E033 0.0000000       12 43795653 43795820 168 +      
ENSG00000198001 E034 0.0000000       12 43795975 43796150 176 +      
ENSG00000198001 E035 0.0000000       12 43798221 43798307 87 +