ENSG00000198000

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000442668 ENSG00000198000 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL8 protein_coding protein_coding 22.79412 6.726548 28.4891 0.9521088 0.8427576 2.080835 6.871376 2.0869432 9.1304447 0.54868664 0.6261602 2.123977 0.3017667 0.3007000 0.31973333 0.019033333 0.882137804 0.002658697 FALSE  
ENST00000463593 ENSG00000198000 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL8 protein_coding retained_intron 22.79412 6.726548 28.4891 0.9521088 0.8427576 2.080835 3.316179 1.4633686 3.8212446 0.25448338 0.1274304 1.378695 0.1606500 0.2158667 0.13420000 -0.081666667 0.002732285 0.002658697 TRUE  
ENST00000538802 ENSG00000198000 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL8 protein_coding retained_intron 22.79412 6.726548 28.4891 0.9521088 0.8427576 2.080835 1.283996 0.2760075 0.6855240 0.06947071 0.1342804 1.282047 0.0660375 0.0432000 0.02396667 -0.019233333 0.392380556 0.002658697    
ENST00000545444 ENSG00000198000 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL8 protein_coding nonsense_mediated_decay 22.79412 6.726548 28.4891 0.9521088 0.8427576 2.080835 0.668575 1.0097745 0.4907445 0.50983663 0.2928465 -1.026103 0.0623875 0.1483333 0.01710000 -0.131233333 0.609116294 0.002658697 FALSE  
MSTRG.32988.4 ENSG00000198000 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL8 protein_coding   22.79412 6.726548 28.4891 0.9521088 0.8427576 2.080835 3.355077 0.8322955 3.9689316 0.32979851 0.4084178 2.239983 0.1330292 0.1323000 0.13996667 0.007666667 0.868853132 0.002658697 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000198000 E001 0.5891098 0.0184601963 3.926682e-01 5.365952e-01 9 92297358 92297358 1 - 0.219 0.000 -9.268
ENSG00000198000 E002 6.4675286 0.0124507376 7.019269e-02 1.436792e-01 9 92297359 92297423 65 - 0.747 1.001 0.979
ENSG00000198000 E003 15.2352371 0.0012682817 9.003369e-04 3.614914e-03 9 92297424 92297483 60 - 1.047 1.362 1.118
ENSG00000198000 E004 15.0816454 0.0012182612 7.162471e-04 2.957130e-03 9 92297484 92297489 6 - 1.040 1.362 1.142
ENSG00000198000 E005 63.6716242 0.0085707671 6.372346e-10 9.807636e-09 9 92297490 92297613 124 - 1.603 2.010 1.374
ENSG00000198000 E006 41.8177786 0.0141993493 3.422160e-07 3.129401e-06 9 92297614 92297616 3 - 1.418 1.840 1.436
ENSG00000198000 E007 150.0874271 0.0066617043 1.715838e-07 1.666037e-06 9 92297617 92297835 219 - 2.026 2.297 0.907
ENSG00000198000 E008 101.5343217 0.0043818121 8.332719e-05 4.437535e-04 9 92297836 92297886 51 - 1.882 2.087 0.687
ENSG00000198000 E009 126.0763154 0.0036698007 8.972241e-08 9.186424e-07 9 92298257 92298336 80 - 1.960 2.206 0.824
ENSG00000198000 E010 79.9958366 0.0003376177 1.617230e-08 1.917748e-07 9 92298337 92298883 547 - 1.757 2.012 0.859
ENSG00000198000 E011 99.3853784 0.0034910323 4.142978e-07 3.724905e-06 9 92298884 92298954 71 - 1.854 2.104 0.838
ENSG00000198000 E012 125.4113994 0.0002994934 5.852165e-09 7.549197e-08 9 92299890 92300016 127 - 1.967 2.182 0.718
ENSG00000198000 E013 23.8533511 0.0026870842 3.416677e-01 4.855881e-01 9 92300017 92300810 794 - 1.341 1.267 -0.260
ENSG00000198000 E014 65.3898763 0.0008181267 2.088117e-03 7.496731e-03 9 92301551 92301578 28 - 1.702 1.867 0.556
ENSG00000198000 E015 137.7546667 0.0002201626 6.593042e-05 3.604814e-04 9 92301579 92301816 238 - 2.028 2.174 0.490
ENSG00000198000 E016 50.1074693 0.0004744099 7.631638e-01 8.465760e-01 9 92301817 92301822 6 - 1.625 1.654 0.096
ENSG00000198000 E017 83.2366583 0.0005019178 6.623691e-02 1.371168e-01 9 92305753 92305830 78 - 1.823 1.917 0.317
ENSG00000198000 E018 74.7782431 0.0005887737 5.536531e-02 1.186193e-01 9 92306886 92306949 64 - 1.776 1.878 0.345
ENSG00000198000 E019 63.7134571 0.0006750940 2.791985e-01 4.189105e-01 9 92306950 92306970 21 - 1.720 1.787 0.226
ENSG00000198000 E020 82.8561601 0.0004351656 6.821067e-02 1.404019e-01 9 92306971 92307024 54 - 1.824 1.917 0.313
ENSG00000198000 E021 0.2934659 0.0296210072 3.256129e-01   9 92308905 92308950 46 - 0.066 0.217 1.983
ENSG00000198000 E022 100.0885859 0.0038499201 1.431198e-01 2.522713e-01 9 92310171 92310261 91 - 1.910 1.994 0.281
ENSG00000198000 E023 107.9591455 0.0089577884 5.073348e-01 6.429147e-01 9 92310553 92310675 123 - 1.953 2.002 0.167
ENSG00000198000 E024 4.0403824 0.0039550629 5.032528e-01 6.392162e-01 9 92310676 92310825 150 - 0.663 0.555 -0.474
ENSG00000198000 E025 105.9173534 0.0003221194 7.482064e-01 8.354970e-01 9 92311146 92311259 114 - 1.956 1.953 -0.009
ENSG00000198000 E026 392.6589350 0.0018126479 5.036824e-06 3.582681e-05 9 92314267 92315383 1117 - 2.546 2.427 -0.394
ENSG00000198000 E027 133.8464153 0.0002954784 4.231772e-06 3.060027e-05 9 92315384 92315688 305 - 2.089 1.917 -0.576
ENSG00000198000 E028 88.7226061 0.0003443386 3.146928e-05 1.862876e-04 9 92315689 92315851 163 - 1.916 1.723 -0.652
ENSG00000198000 E029 71.9350846 0.0006377650 6.396611e-06 4.445247e-05 9 92315852 92315956 105 - 1.836 1.593 -0.821
ENSG00000198000 E030 46.6430180 0.0004691127 3.727481e-03 1.237618e-02 9 92315957 92315981 25 - 1.642 1.460 -0.622
ENSG00000198000 E031 81.7385883 0.0009017850 5.304429e-05 2.970026e-04 9 92315982 92316093 112 - 1.885 1.684 -0.679
ENSG00000198000 E032 54.7669861 0.0040620766 1.115782e-05 7.331997e-05 9 92316094 92316138 45 - 1.728 1.420 -1.052
ENSG00000198000 E033 48.5552882 0.0038063045 4.513967e-04 1.972090e-03 9 92318618 92318668 51 - 1.667 1.421 -0.843
ENSG00000198000 E034 39.2970473 0.0005590391 2.620499e-03 9.128691e-03 9 92318669 92318686 18 - 1.572 1.362 -0.721
ENSG00000198000 E035 0.5891098 0.0184601963 3.926682e-01 5.365952e-01 9 92318687 92318947 261 - 0.219 0.000 -11.560
ENSG00000198000 E036 57.2645237 0.0004310950 7.452582e-07 6.363785e-06 9 92319221 92319277 57 - 1.747 1.440 -1.045
ENSG00000198000 E037 40.0528223 0.0005515705 4.587438e-07 4.087463e-06 9 92319278 92319287 10 - 1.607 1.219 -1.342
ENSG00000198000 E038 46.3762791 0.0006027524 2.433216e-08 2.789713e-07 9 92319288 92319319 32 - 1.672 1.267 -1.394
ENSG00000198000 E039 48.8000649 0.0024531789 3.040491e-05 1.806473e-04 9 92319320 92319356 37 - 1.678 1.386 -0.999
ENSG00000198000 E040 12.8571445 0.0013129971 5.869491e-03 1.826924e-02 9 92319943 92319987 45 - 1.133 0.791 -1.281
ENSG00000198000 E041 20.2591897 0.0009745438 4.339442e-03 1.409409e-02 9 92319988 92320129 142 - 1.311 1.030 -1.003
ENSG00000198000 E042 8.3412129 0.1456971048 4.521082e-01 5.930041e-01 9 92320130 92320137 8 - 0.941 0.783 -0.608
ENSG00000198000 E043 10.1884751 0.0035470317 1.370603e-01 2.439963e-01 9 92320138 92320190 53 - 1.021 0.834 -0.703
ENSG00000198000 E044 13.9153287 0.0012747215 5.096244e-01 6.449266e-01 9 92320191 92320379 189 - 1.117 1.055 -0.224
ENSG00000198000 E045 3.5064432 0.0044578045 1.243542e-01 2.262024e-01 9 92320380 92320382 3 - 0.647 0.361 -1.406
ENSG00000198000 E046 51.8189623 0.0004471392 8.759681e-05 4.637794e-04 9 92321668 92321746 79 - 1.695 1.450 -0.836
ENSG00000198000 E047 5.1412854 0.0030608887 1.647689e-02 4.378959e-02 9 92322850 92323136 287 - 0.795 0.361 -2.014
ENSG00000198000 E048 1.8414119 0.0081249986 2.514452e-01 3.876937e-01 9 92323137 92323235 99 - 0.447 0.217 -1.473
ENSG00000198000 E049 9.1517460 0.0738876818 1.037496e-01 1.962209e-01 9 92323236 92323351 116 - 1.000 0.686 -1.227
ENSG00000198000 E050 2.2238358 0.0070497921 9.373406e-01 9.646317e-01 9 92323352 92323440 89 - 0.447 0.469 0.112
ENSG00000198000 E051 60.9948087 0.0020938578 3.658776e-06 2.687022e-05 9 92323441 92323503 63 - 1.771 1.480 -0.993
ENSG00000198000 E052 59.9412490 0.0018024472 1.390801e-06 1.119537e-05 9 92324023 92324080 58 - 1.767 1.460 -1.043
ENSG00000198000 E053 61.4555330 0.0312764220 1.065485e-03 4.185737e-03 9 92324081 92324209 129 - 1.781 1.447 -1.139
ENSG00000198000 E054 1.4833268 0.0089719393 6.329540e-02 1.322006e-01 9 92324210 92324251 42 - 0.421 0.000 -12.834
ENSG00000198000 E055 4.1104285 0.0039642406 6.085704e-02 1.280832e-01 9 92324252 92324608 357 - 0.707 0.361 -1.658
ENSG00000198000 E056 1.2169414 0.1466548842 6.218607e-01 7.387706e-01 9 92324609 92324675 67 - 0.331 0.217 -0.819
ENSG00000198000 E057 5.2186272 0.0034158659 6.727283e-01 7.785884e-01 9 92324906 92325179 274 - 0.747 0.689 -0.237
ENSG00000198000 E058 13.5372356 0.0385442719 6.648341e-01 7.726001e-01 9 92325180 92325305 126 - 1.107 1.056 -0.185
ENSG00000198000 E059 17.1501868 0.0010260860 3.166941e-06 2.356695e-05 9 92325306 92325317 12 - 1.275 0.689 -2.198
ENSG00000198000 E060 19.2893270 0.0009415661 7.908242e-04 3.226361e-03 9 92325318 92325456 139 - 1.297 0.943 -1.275
ENSG00000198000 E061 3.2441973 0.0049474884 4.614538e-01 6.014023e-01 9 92325457 92325526 70 - 0.596 0.469 -0.599
ENSG00000198000 E062 2.2144863 0.0251197093 5.569917e-01 6.855135e-01 9 92325527 92325568 42 - 0.472 0.362 -0.594
ENSG00000198000 E063 1.9198745 0.0074262980 7.338743e-01 8.250223e-01 9 92325569 92325636 68 - 0.421 0.361 -0.335