ENSG00000197989

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000461448 ENSG00000197989 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG12 lncRNA retained_intron 54.96961 49.07777 51.57817 4.981893 1.332833 0.07167673 6.121915 3.683344 8.504580 0.1872925 0.4589099 1.20500788 0.1115917 0.07763333 0.1648000 0.08716667 9.866434e-04 9.626509e-12   FALSE
ENST00000461832 ENSG00000197989 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG12 lncRNA retained_intron 54.96961 49.07777 51.57817 4.981893 1.332833 0.07167673 22.272137 21.715132 15.965532 2.5734861 0.1652425 -0.44350096 0.4051833 0.44123333 0.3098667 -0.13136667 3.436788e-06 9.626509e-12   FALSE
ENST00000464612 ENSG00000197989 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG12 lncRNA retained_intron 54.96961 49.07777 51.57817 4.981893 1.332833 0.07167673 8.859352 7.083684 9.984514 0.8985168 0.4377625 0.49460133 0.1602667 0.14453333 0.1937000 0.04916667 1.142471e-01 9.626509e-12   FALSE
ENST00000650239 ENSG00000197989 HEK293_OSMI2_2hA HEK293_TMG_2hB SNHG12 lncRNA lncRNA 54.96961 49.07777 51.57817 4.981893 1.332833 0.07167673 6.625286 5.478446 5.406360 0.5241111 0.1559900 -0.01907425 0.1203250 0.11256667 0.1049667 -0.00760000 8.418943e-01 9.626509e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197989 E001 1.2521237 0.1228817576 6.831178e-02 1.405779e-01 1 28578538 28578538 1 - 0.126 0.497 2.664
ENSG00000197989 E002 1.2521237 0.1228817576 6.831178e-02 1.405779e-01 1 28578539 28578540 2 - 0.126 0.497 2.664
ENSG00000197989 E003 1.9122206 0.0669900239 1.488400e-01 2.600963e-01 1 28578541 28578545 5 - 0.304 0.578 1.459
ENSG00000197989 E004 18.1324897 0.0012048018 5.992076e-02 1.264741e-01 1 28578546 28578554 9 - 1.191 1.342 0.533
ENSG00000197989 E005 18.6107804 0.0015392573 3.488608e-02 8.143351e-02 1 28578555 28578555 1 - 1.191 1.361 0.596
ENSG00000197989 E006 99.5464289 0.0062014985 2.676898e-02 6.550801e-02 1 28578556 28578590 35 - 1.930 2.048 0.398
ENSG00000197989 E007 247.8263043 0.0039261992 3.935104e-03 1.296015e-02 1 28578591 28578680 90 - 2.328 2.437 0.365
ENSG00000197989 E008 135.8136902 0.0098580004 4.106872e-01 5.542939e-01 1 28579010 28579532 523 - 2.108 2.154 0.151
ENSG00000197989 E009 306.9560371 0.0025506112 3.725081e-04 1.667704e-03 1 28579533 28579587 55 - 2.417 2.530 0.375
ENSG00000197989 E010 273.3881458 0.0001972625 1.606252e-02 4.287540e-02 1 28579588 28579682 95 - 2.402 2.454 0.172
ENSG00000197989 E011 329.0025646 0.0001833027 1.570126e-03 5.862234e-03 1 28579683 28579763 81 - 2.477 2.539 0.206
ENSG00000197989 E012 297.3010867 0.0001536998 1.147921e-02 3.230588e-02 1 28579764 28579843 80 - 2.441 2.492 0.170
ENSG00000197989 E013 230.8935138 0.0002194130 3.342063e-01 4.779634e-01 1 28579844 28579911 68 - 2.348 2.369 0.071
ENSG00000197989 E014 238.6440208 0.0002429692 9.162200e-02 1.776657e-01 1 28579912 28579941 30 - 2.352 2.390 0.127
ENSG00000197989 E015 308.5647227 0.0033992660 8.759638e-01 9.243458e-01 1 28579942 28579981 40 - 2.485 2.486 0.005
ENSG00000197989 E016 140.1694239 0.0085487104 1.070152e-09 1.578088e-08 1 28579982 28580334 353 - 2.304 1.968 -1.125
ENSG00000197989 E017 57.3165011 0.0083295731 2.051880e-05 1.269547e-04 1 28580335 28580380 46 - 1.898 1.617 -0.949
ENSG00000197989 E018 57.3531189 0.0060565172 1.089548e-05 7.177534e-05 1 28580381 28580424 44 - 1.892 1.624 -0.906
ENSG00000197989 E019 90.4956138 0.0004903674 3.976354e-19 2.297431e-17 1 28580425 28580559 135 - 2.117 1.773 -1.156
ENSG00000197989 E020 376.5389415 0.0009796492 9.534274e-01 9.748636e-01 1 28580560 28580646 87 - 2.571 2.571 0.001
ENSG00000197989 E021 151.0779477 0.0020974739 5.298498e-21 3.822485e-19 1 28580647 28580919 273 - 2.339 1.999 -1.137
ENSG00000197989 E022 92.0954832 0.0041482498 8.905692e-10 1.332562e-08 1 28580920 28581093 174 - 2.109 1.810 -1.005
ENSG00000197989 E023 59.3651533 0.0071680037 9.879823e-02 1.886436e-01 1 28581094 28581110 17 - 1.825 1.726 -0.336
ENSG00000197989 E024 218.7028317 0.0066499901 9.530365e-02 1.833335e-01 1 28581111 28581134 24 - 2.289 2.368 0.263
ENSG00000197989 E025 280.2955058 0.0019293077 4.813356e-02 1.058659e-01 1 28581135 28581229 95 - 2.409 2.467 0.196
ENSG00000197989 E026 31.0286928 0.0006715690 6.602058e-11 1.199981e-09 1 28581230 28581589 360 - 1.687 1.269 -1.438
ENSG00000197989 E027 280.8888334 0.0003971993 3.232884e-04 1.474032e-03 1 28581590 28582089 500 - 2.396 2.477 0.268
ENSG00000197989 E028 0.6902858 0.6972774302 6.382454e-01 7.519180e-01 1 28582090 28583132 1043 - 0.126 0.291 1.502