ENSG00000197961

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320451 ENSG00000197961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF121 protein_coding protein_coding 7.854383 2.690005 11.16337 0.2736238 0.3048876 2.04903 6.0988487 2.5907281 8.0542008 0.3120823 0.1554293 1.632616 0.83542083 0.95956667 0.72230000 -0.23726667 4.857512e-07 4.857512e-07 FALSE TRUE
MSTRG.16378.4 ENSG00000197961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF121 protein_coding   7.854383 2.690005 11.16337 0.2736238 0.3048876 2.04903 0.3628987 0.0000000 1.0548666 0.0000000 0.4348449 6.734529 0.03203750 0.00000000 0.09676667 0.09676667 2.750396e-03 4.857512e-07 FALSE TRUE
MSTRG.16378.5 ENSG00000197961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF121 protein_coding   7.854383 2.690005 11.16337 0.2736238 0.3048876 2.04903 0.6682411 0.0000000 0.7022038 0.0000000 0.4469639 6.154218 0.05724583 0.00000000 0.06086667 0.06086667 4.290956e-01 4.857512e-07 FALSE FALSE
MSTRG.16378.6 ENSG00000197961 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF121 protein_coding   7.854383 2.690005 11.16337 0.2736238 0.3048876 2.04903 0.5509925 0.0530909 1.2304835 0.0530909 0.2695333 4.297327 0.04850000 0.01933333 0.10906667 0.08973333 1.064830e-01 4.857512e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197961 E001 0.9566701 0.1395561949 5.698138e-02 1.214280e-01 19 9560329 9560352 24 - 0.120 0.559 3.042
ENSG00000197961 E002 429.2229077 0.0047410924 2.162657e-45 1.034618e-42 19 9560353 9562591 2239 - 2.399 2.865 1.553
ENSG00000197961 E003 229.8814281 0.0002614847 5.044837e-08 5.435839e-07 19 9562592 9564287 1696 - 2.287 2.269 -0.062
ENSG00000197961 E004 41.0678094 0.0076764046 4.526515e-04 1.977162e-03 19 9564288 9564495 208 - 1.574 1.411 -0.561
ENSG00000197961 E005 155.2303997 0.0038346137 3.507318e-12 7.872641e-11 19 9564496 9566088 1593 - 2.150 1.960 -0.638
ENSG00000197961 E006 45.7314295 0.0005363892 8.689003e-08 8.925851e-07 19 9566089 9566335 247 - 1.636 1.396 -0.822
ENSG00000197961 E007 53.7854767 0.0005021863 4.732112e-05 2.681917e-04 19 9566336 9566659 324 - 1.685 1.567 -0.401
ENSG00000197961 E008 100.0412604 0.0004043601 9.971442e-12 2.077259e-10 19 9566660 9567109 450 - 1.962 1.784 -0.600
ENSG00000197961 E009 1.9230096 0.0084182970 4.388851e-01 5.807018e-01 19 9567648 9567705 58 - 0.440 0.367 -0.403
ENSG00000197961 E010 0.1515154 0.0428423741 1.000000e+00   19 9567706 9567743 38 - 0.064 0.001 -6.090
ENSG00000197961 E011 45.4631483 0.0207709195 5.601124e-06 3.942472e-05 19 9568095 9568175 81 - 1.649 1.306 -1.179
ENSG00000197961 E012 41.9683453 0.0006564514 1.511533e-09 2.167389e-08 19 9569002 9569082 81 - 1.613 1.292 -1.107
ENSG00000197961 E013 1.8319738 0.1104711718 6.141001e-01 7.326595e-01 19 9584186 9584348 163 - 0.414 0.368 -0.257
ENSG00000197961 E014 23.1507097 0.0008325605 1.364726e-03 5.191840e-03 19 9584461 9584531 71 - 1.343 1.174 -0.594