ENSG00000197948

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000435817 ENSG00000197948 HEK293_OSMI2_2hA HEK293_TMG_2hB FCHSD1 protein_coding protein_coding 5.626811 6.653531 3.770981 0.5593387 0.581526 -0.8175262 0.76403180 1.79134199 0.3835759 0.24255100 0.007570597 -2.1943582 0.12701250 0.27140000 0.10583333 -0.16556667 0.004271404 0.004271404 FALSE TRUE
ENST00000519800 ENSG00000197948 HEK293_OSMI2_2hA HEK293_TMG_2hB FCHSD1 protein_coding protein_coding 5.626811 6.653531 3.770981 0.5593387 0.581526 -0.8175262 0.49310551 0.06734620 0.2215842 0.06734620 0.221584150 1.5821341 0.09036667 0.01203333 0.04493333 0.03290000 0.945249128 0.004271404 FALSE TRUE
ENST00000520747 ENSG00000197948 HEK293_OSMI2_2hA HEK293_TMG_2hB FCHSD1 protein_coding retained_intron 5.626811 6.653531 3.770981 0.5593387 0.581526 -0.8175262 0.52415915 0.32205454 0.2289150 0.16380885 0.160394131 -0.4749226 0.09184167 0.04516667 0.07233333 0.02716667 0.978517076 0.004271404   FALSE
ENST00000522386 ENSG00000197948 HEK293_OSMI2_2hA HEK293_TMG_2hB FCHSD1 protein_coding processed_transcript 5.626811 6.653531 3.770981 0.5593387 0.581526 -0.8175262 0.31737254 0.13447196 0.3773874 0.13447196 0.201380101 1.4229874 0.05598750 0.02403333 0.09230000 0.06826667 0.523631840 0.004271404   FALSE
ENST00000522783 ENSG00000197948 HEK293_OSMI2_2hA HEK293_TMG_2hB FCHSD1 protein_coding protein_coding 5.626811 6.653531 3.770981 0.5593387 0.581526 -0.8175262 0.26077327 0.47577876 0.0444258 0.27399712 0.044425795 -3.1579369 0.04008750 0.07456667 0.00900000 -0.06556667 0.539297554 0.004271404 TRUE TRUE
ENST00000523856 ENSG00000197948 HEK293_OSMI2_2hA HEK293_TMG_2hB FCHSD1 protein_coding processed_transcript 5.626811 6.653531 3.770981 0.5593387 0.581526 -0.8175262 0.50378244 0.30279657 0.3318087 0.09448749 0.062033206 0.1279645 0.09090000 0.04373333 0.08743333 0.04370000 0.156333622 0.004271404 FALSE TRUE
MSTRG.27075.2 ENSG00000197948 HEK293_OSMI2_2hA HEK293_TMG_2hB FCHSD1 protein_coding   5.626811 6.653531 3.770981 0.5593387 0.581526 -0.8175262 0.07761039 0.07002588 0.3071498 0.07002588 0.153711684 1.9866259 0.01741667 0.01250000 0.07903333 0.06653333 0.474306841 0.004271404 TRUE TRUE
MSTRG.27075.7 ENSG00000197948 HEK293_OSMI2_2hA HEK293_TMG_2hB FCHSD1 protein_coding   5.626811 6.653531 3.770981 0.5593387 0.581526 -0.8175262 2.14548638 2.86120103 1.6046153 0.53237969 0.087902528 -0.8304639 0.38565833 0.42386667 0.44606667 0.02220000 0.959125922 0.004271404 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197948 E001 0.2214452 0.0370815050 1.000000e+00   5 141639302 141639302 1 - 0.000 0.084 7.769
ENSG00000197948 E002 0.2214452 0.0370815050 1.000000e+00   5 141639303 141639307 5 - 0.000 0.084 10.282
ENSG00000197948 E003 75.8212913 0.0003861038 6.579069e-01 7.671855e-01 5 141639308 141640981 1674 - 1.809 1.826 0.060
ENSG00000197948 E004 5.6765323 0.0030766502 6.796535e-01 7.837640e-01 5 141640982 141640986 5 - 0.812 0.754 -0.233
ENSG00000197948 E005 42.7774273 0.0030259257 5.535365e-02 1.185983e-01 5 141640987 141641208 222 - 1.491 1.614 0.422
ENSG00000197948 E006 80.2800390 0.0003513709 2.836715e-01 4.238159e-01 5 141641209 141641563 355 - 1.815 1.859 0.148
ENSG00000197948 E007 26.8131961 0.0009703704 7.832481e-01 8.608824e-01 5 141641702 141641757 56 - 1.397 1.375 -0.076
ENSG00000197948 E008 10.5599651 0.0017290287 1.954823e-07 1.876841e-06 5 141641758 141642396 639 - 1.321 0.800 -1.911
ENSG00000197948 E009 5.4467698 0.0029719390 2.049703e-01 3.323705e-01 5 141642397 141642503 107 - 0.874 0.702 -0.685
ENSG00000197948 E010 2.0889040 0.1359868736 2.411819e-01 3.755677e-01 5 141642504 141642704 201 - 0.601 0.363 -1.191
ENSG00000197948 E011 28.8852579 0.0008742454 8.105881e-01 8.798161e-01 5 141643001 141643088 88 - 1.397 1.413 0.054
ENSG00000197948 E012 54.3916213 0.0005072755 7.301399e-02 1.483593e-01 5 141644218 141644438 221 - 1.607 1.701 0.322
ENSG00000197948 E013 36.1855157 0.0006353994 1.738250e-01 2.931596e-01 5 141644573 141644629 57 - 1.446 1.533 0.297
ENSG00000197948 E014 36.1535506 0.0006547158 1.533444e-01 2.662282e-01 5 141644630 141644690 61 - 1.439 1.530 0.315
ENSG00000197948 E015 35.8512019 0.0006355957 3.583622e-01 5.027541e-01 5 141644859 141644938 80 - 1.462 1.519 0.198
ENSG00000197948 E016 19.1218451 0.0010112702 8.458337e-01 9.041275e-01 5 141644939 141644942 4 - 1.230 1.245 0.053
ENSG00000197948 E017 38.4209763 0.0005929594 9.787257e-01 9.907965e-01 5 141645020 141645148 129 - 1.531 1.531 -0.001
ENSG00000197948 E018 19.6928991 0.0027454408 2.489470e-01 3.846904e-01 5 141645771 141645821 51 - 1.332 1.234 -0.343
ENSG00000197948 E019 30.9213081 0.0072885771 5.633165e-01 6.908025e-01 5 141645822 141645932 111 - 1.414 1.457 0.148
ENSG00000197948 E020 35.7915814 0.0006371760 5.067794e-01 6.424335e-01 5 141646087 141646191 105 - 1.537 1.493 -0.149
ENSG00000197948 E021 6.3504024 0.0387863997 1.501617e-04 7.476789e-04 5 141646192 141646507 316 - 1.145 0.578 -2.219
ENSG00000197948 E022 2.7271318 0.0060932303 3.611848e-03 1.204333e-02 5 141646508 141646602 95 - 0.812 0.357 -2.107
ENSG00000197948 E023 25.7013907 0.0007973354 6.226787e-01 7.394293e-01 5 141646603 141646671 69 - 1.397 1.359 -0.132
ENSG00000197948 E024 23.9221223 0.0008256315 6.613584e-01 7.698125e-01 5 141646672 141646722 51 - 1.361 1.326 -0.122
ENSG00000197948 E025 24.4605900 0.0008075795 8.815414e-01 9.280964e-01 5 141647135 141647230 96 - 1.342 1.351 0.033
ENSG00000197948 E026 31.0924364 0.0016248865 6.150349e-01 7.333843e-01 5 141647398 141647520 123 - 1.476 1.440 -0.125
ENSG00000197948 E027 4.6112146 0.0058178685 1.823856e-03 6.676150e-03 5 141647521 141647831 311 - 0.977 0.550 -1.737
ENSG00000197948 E028 1.9281918 0.0080119411 9.795143e-03 2.825821e-02 5 141647884 141647967 84 - 0.698 0.267 -2.233
ENSG00000197948 E029 25.1503960 0.0037100076 5.324332e-01 6.647984e-01 5 141647968 141648096 129 - 1.321 1.371 0.174
ENSG00000197948 E030 26.5364549 0.0009119791 9.250066e-01 9.567785e-01 5 141648957 141649020 64 - 1.370 1.375 0.018
ENSG00000197948 E031 33.1567840 0.0007144416 9.393568e-01 9.659073e-01 5 141649172 141649308 137 - 1.476 1.469 -0.024
ENSG00000197948 E032 27.7565884 0.0007771129 4.638382e-01 6.036087e-01 5 141649395 141649530 136 - 1.361 1.412 0.178
ENSG00000197948 E033 1.1855920 0.0117830301 2.564574e-02 6.321161e-02 5 141649531 141649536 6 - 0.543 0.154 -2.553
ENSG00000197948 E034 23.5444500 0.0008476104 3.017838e-01 4.436068e-01 5 141649887 141649954 68 - 1.266 1.347 0.282
ENSG00000197948 E035 24.7098319 0.0044116226 3.124862e-01 4.550195e-01 5 141650359 141650404 46 - 1.289 1.372 0.288
ENSG00000197948 E036 29.4361523 0.0007438756 4.286011e-01 5.713324e-01 5 141651020 141651117 98 - 1.462 1.405 -0.194
ENSG00000197948 E037 21.2114168 0.0021357473 2.668826e-01 4.051421e-01 5 141651348 141651418 71 - 1.351 1.260 -0.318