ENSG00000197930

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395686 ENSG00000197930 HEK293_OSMI2_2hA HEK293_TMG_2hB ERO1A protein_coding protein_coding 22.55728 8.15894 31.52222 0.2526654 1.177066 1.948606 14.970140 7.87593114 18.657916 0.22638431 0.6997563 1.243208 0.76535833 0.965500000 0.5919667 -0.3735333 1.412179e-42 1.412179e-42 FALSE TRUE
ENST00000554019 ENSG00000197930 HEK293_OSMI2_2hA HEK293_TMG_2hB ERO1A protein_coding nonsense_mediated_decay 22.55728 8.15894 31.52222 0.2526654 1.177066 1.948606 4.412019 0.00000000 7.886205 0.00000000 0.4330447 9.625016 0.12645833 0.000000000 0.2519667 0.2519667 6.078098e-25 1.412179e-42 TRUE TRUE
MSTRG.9546.6 ENSG00000197930 HEK293_OSMI2_2hA HEK293_TMG_2hB ERO1A protein_coding   22.55728 8.15894 31.52222 0.2526654 1.177066 1.948606 2.334811 0.03609847 3.794038 0.01808285 0.6521671 6.366669 0.06745417 0.004533333 0.1191000 0.1145667 3.675867e-10 1.412179e-42 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197930 E001 1107.2460823 0.0056878808 1.990445e-26 2.450188e-24 14 52639915 52643215 3301 - 2.839 3.243 1.344
ENSG00000197930 E002 29.0195500 0.0297955651 2.999745e-01 4.415947e-01 14 52643216 52643287 72 - 1.343 1.552 0.718
ENSG00000197930 E003 33.3986685 0.0006370234 1.292268e-03 4.949885e-03 14 52643288 52643404 117 - 1.373 1.683 1.059
ENSG00000197930 E004 177.2603106 0.0002123049 3.678900e-01 5.122814e-01 14 52643405 52643630 226 - 2.142 2.275 0.446
ENSG00000197930 E005 110.0488672 0.0003291438 4.352505e-01 5.774882e-01 14 52646154 52646191 38 - 1.954 2.030 0.255
ENSG00000197930 E006 134.2785355 0.0003354468 8.193410e-01 8.859281e-01 14 52646192 52646251 60 - 2.031 2.129 0.330
ENSG00000197930 E007 121.0820804 0.0002854768 6.175119e-01 7.352879e-01 14 52646252 52646287 36 - 1.990 2.078 0.295
ENSG00000197930 E008 1.3340015 0.0115349898 5.303597e-02 1.145459e-01 14 52646288 52646374 87 - 0.390 0.000 -12.869
ENSG00000197930 E009 95.8096261 0.0003255750 2.009437e-01 3.273640e-01 14 52646375 52646378 4 - 1.899 1.952 0.177
ENSG00000197930 E010 165.4988276 0.0002865232 1.123312e-02 3.172405e-02 14 52646379 52646461 83 - 2.141 2.166 0.082
ENSG00000197930 E011 1.9282038 0.0130970509 5.804939e-02 1.232962e-01 14 52646462 52647124 663 - 0.294 0.693 2.017
ENSG00000197930 E012 131.8470948 0.0016260947 1.420420e-01 2.508289e-01 14 52652239 52652308 70 - 2.037 2.085 0.158
ENSG00000197930 E013 260.4481801 0.0021644131 6.055029e-05 3.341803e-04 14 52653069 52653315 247 - 2.349 2.318 -0.103
ENSG00000197930 E014 105.7529592 0.0011538133 5.133832e-04 2.209686e-03 14 52657917 52657948 32 - 1.963 1.915 -0.160
ENSG00000197930 E015 124.5282560 0.0008621187 7.407318e-07 6.330269e-06 14 52657949 52658009 61 - 2.043 1.946 -0.327
ENSG00000197930 E016 0.2987644 0.0275232831 7.751069e-01   14 52658010 52658026 17 - 0.122 0.000 -10.700
ENSG00000197930 E017 99.7111389 0.0002772891 1.462684e-06 1.172666e-05 14 52658124 52658150 27 - 1.951 1.848 -0.348
ENSG00000197930 E018 3.8661813 0.0107605425 5.431205e-03 1.710144e-02 14 52658151 52658541 391 - 0.703 0.219 -2.626
ENSG00000197930 E019 83.7363182 0.0003450969 2.222294e-04 1.058893e-03 14 52661293 52661304 12 - 1.871 1.805 -0.223
ENSG00000197930 E020 0.5848434 0.0247843030 3.056396e-01 4.477632e-01 14 52663781 52663800 20 - 0.217 0.000 -11.699
ENSG00000197930 E021 134.5076700 0.0005397043 4.431971e-06 3.192242e-05 14 52663801 52663847 47 - 2.073 2.005 -0.227
ENSG00000197930 E022 0.1451727 0.0431051554 1.000000e+00   14 52663848 52664202 355 - 0.065 0.000 -9.699
ENSG00000197930 E023 100.1754586 0.0004019554 1.275994e-03 4.897153e-03 14 52666375 52666376 2 - 1.939 1.908 -0.103
ENSG00000197930 E024 164.3886515 0.0014334458 2.322480e-05 1.418580e-04 14 52666377 52666495 119 - 2.157 2.105 -0.174
ENSG00000197930 E025 0.5869318 0.3136011140 3.638199e-01 5.082506e-01 14 52671574 52671629 56 - 0.121 0.356 1.980
ENSG00000197930 E026 147.6635079 0.0002657339 2.340446e-09 3.240448e-08 14 52671630 52671703 74 - 2.120 2.011 -0.366
ENSG00000197930 E027 106.3090113 0.0002548916 4.168168e-09 5.506603e-08 14 52671795 52671824 30 - 1.986 1.840 -0.492
ENSG00000197930 E028 129.8733487 0.0014610831 6.808046e-08 7.143527e-07 14 52671825 52671871 47 - 2.068 1.945 -0.413
ENSG00000197930 E029 0.2987644 0.0275232831 7.751069e-01   14 52671872 52672235 364 - 0.122 0.000 -10.700
ENSG00000197930 E030 0.6589510 0.0243822273 3.448488e-02 8.068492e-02 14 52678319 52678433 115 - 0.065 0.472 3.603
ENSG00000197930 E031 119.9603815 0.0004485824 4.948177e-08 5.339279e-07 14 52678434 52678472 39 - 2.033 1.918 -0.386
ENSG00000197930 E032 164.8484778 0.0002506716 1.533356e-12 3.644331e-11 14 52682325 52682408 84 - 2.173 2.035 -0.463
ENSG00000197930 E033 132.0123028 0.0002996094 9.681550e-12 2.022652e-10 14 52683788 52683907 120 - 2.080 1.919 -0.540
ENSG00000197930 E034 126.6344095 0.0036986987 4.828662e-09 6.319693e-08 14 52695368 52695900 533 - 2.066 1.877 -0.636