ENSG00000197905

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358409 ENSG00000197905 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD4 protein_coding protein_coding 33.16171 53.06833 22.0909 1.883024 0.2459074 -1.264017 2.790678 4.234001 2.575275 0.4158748 0.7164364 -0.7151071 0.08082500 0.07990000 0.11623333 0.036333333 6.635021e-01 1.322676e-06 FALSE  
ENST00000359864 ENSG00000197905 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD4 protein_coding protein_coding 33.16171 53.06833 22.0909 1.883024 0.2459074 -1.264017 19.719971 31.191149 12.360949 2.3057377 0.5663131 -1.3346430 0.60464583 0.58610000 0.56013333 -0.025966667 8.384337e-01 1.322676e-06 FALSE  
ENST00000397122 ENSG00000197905 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD4 protein_coding protein_coding 33.16171 53.06833 22.0909 1.883024 0.2459074 -1.264017 1.879549 4.657750 0.000000 1.9756140 0.0000000 -8.8665836 0.05132917 0.09063333 0.00000000 -0.090633333 1.322676e-06 1.322676e-06 FALSE  
MSTRG.6628.1 ENSG00000197905 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD4 protein_coding   33.16171 53.06833 22.0909 1.883024 0.2459074 -1.264017 2.430902 3.101495 1.241229 0.7517025 0.2233353 -1.3142625 0.06995833 0.05776667 0.05613333 -0.001633333 1.000000e+00 1.322676e-06 FALSE  
MSTRG.6628.2 ENSG00000197905 HEK293_OSMI2_2hA HEK293_TMG_2hB TEAD4 protein_coding   33.16171 53.06833 22.0909 1.883024 0.2459074 -1.264017 3.460211 5.212470 3.492079 0.9696037 0.1974819 -0.5765208 0.10692917 0.09783333 0.15793333 0.060100000 9.550960e-02 1.322676e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197905 E001 0.8115846 0.5403258256 0.94689261 0.97066125 12 2959293 2959311 19 + 0.189 0.213 0.218
ENSG00000197905 E002 1.1103491 0.3675290957 0.31834455 0.46131749 12 2959312 2959313 2 + 0.420 0.210 -1.393
ENSG00000197905 E003 1.3317943 0.5189011702 0.41579285 0.55913388 12 2959314 2959316 3 + 0.420 0.268 -0.932
ENSG00000197905 E004 3.7611781 0.1200259652 0.21645137 0.34614222 12 2959317 2959329 13 + 0.770 0.536 -1.004
ENSG00000197905 E005 22.4544429 0.0013521607 0.10853145 0.20338053 12 2959330 2959396 67 + 1.387 1.255 -0.460
ENSG00000197905 E006 25.8863170 0.0020670286 0.12359932 0.22509177 12 2959397 2959405 9 + 1.441 1.320 -0.419
ENSG00000197905 E007 25.3693296 0.0025670814 0.13202054 0.23692415 12 2959406 2959406 1 + 1.433 1.312 -0.418
ENSG00000197905 E008 85.2403908 0.0146451008 0.53685598 0.66853697 12 2959407 2959481 75 + 1.890 1.848 -0.139
ENSG00000197905 E009 7.5190229 0.0021995807 0.66044343 0.76910184 12 2959796 2959916 121 + 0.907 0.848 -0.225
ENSG00000197905 E010 11.6704283 0.0016037849 0.65377689 0.76416157 12 2959917 2959943 27 + 1.074 1.023 -0.186
ENSG00000197905 E011 11.5629201 0.0015340267 0.79839446 0.87133076 12 2959944 2959947 4 + 1.054 1.023 -0.112
ENSG00000197905 E012 145.6168503 0.0041284334 0.87177496 0.92153731 12 2959948 2960040 93 + 2.095 2.086 -0.028
ENSG00000197905 E013 10.4417093 0.0528807950 0.81785413 0.88482543 12 2960041 2960196 156 + 1.032 0.980 -0.194
ENSG00000197905 E014 9.6191255 0.0027588745 0.40715795 0.55076974 12 2960197 2960353 157 + 1.033 0.935 -0.364
ENSG00000197905 E015 338.1316434 0.0046906090 0.05576848 0.11929555 12 2994738 2994992 255 + 2.507 2.436 -0.236
ENSG00000197905 E016 175.2737622 0.0002273372 0.30733346 0.44954602 12 3011004 3011043 40 + 2.194 2.160 -0.115
ENSG00000197905 E017 143.7618341 0.0002891251 0.35209433 0.49634062 12 3011044 3011068 25 + 2.061 2.090 0.097
ENSG00000197905 E018 189.3968983 0.0001894435 0.37536349 0.51979041 12 3012170 3012232 63 + 2.223 2.194 -0.097
ENSG00000197905 E019 1.2458707 0.1653126168 0.08930681 0.17408075 12 3017063 3017095 33 + 0.570 0.199 -2.221
ENSG00000197905 E020 234.1131734 0.0002948565 0.66999660 0.77660945 12 3017398 3017526 129 + 2.286 2.295 0.028
ENSG00000197905 E021 134.0184379 0.0006511496 0.75687818 0.84188839 12 3018545 3018588 44 + 2.046 2.055 0.027
ENSG00000197905 E022 164.9760114 0.0008512836 0.17482644 0.29447373 12 3019115 3019170 56 + 2.106 2.150 0.147
ENSG00000197905 E023 244.9344372 0.0039631561 0.88952364 0.93337756 12 3020634 3020773 140 + 2.310 2.314 0.013
ENSG00000197905 E024 392.5012272 0.0004800364 0.46274427 0.60259910 12 3021844 3022017 174 + 2.507 2.521 0.045
ENSG00000197905 E025 488.6787773 0.0004893321 0.04195862 0.09464895 12 3037968 3038108 141 + 2.583 2.622 0.128
ENSG00000197905 E026 583.5792111 0.0018392095 0.16584683 0.28279839 12 3040107 3040259 153 + 2.665 2.698 0.109
ENSG00000197905 E027 428.3507670 0.0023977553 0.56131499 0.68916801 12 3040365 3040676 312 + 2.570 2.553 -0.057