ENSG00000197894

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296412 ENSG00000197894 HEK293_OSMI2_2hA HEK293_TMG_2hB ADH5 protein_coding protein_coding 78.19651 46.58327 109.0667 12.0846 1.647484 1.22715 22.196853 14.681329 36.36682 5.1877140 2.159153 1.3080545 0.2611042 0.30396667 0.3335000 0.02953333 0.804941382 0.002638021 FALSE TRUE
ENST00000502590 ENSG00000197894 HEK293_OSMI2_2hA HEK293_TMG_2hB ADH5 protein_coding nonsense_mediated_decay 78.19651 46.58327 109.0667 12.0846 1.647484 1.22715 9.079558 3.427704 12.89253 0.8322587 2.080853 1.9081362 0.1125500 0.07753333 0.1179333 0.04040000 0.443860404 0.002638021 FALSE FALSE
ENST00000512621 ENSG00000197894 HEK293_OSMI2_2hA HEK293_TMG_2hB ADH5 protein_coding retained_intron 78.19651 46.58327 109.0667 12.0846 1.647484 1.22715 18.314737 9.178160 25.14237 2.0678075 1.635600 1.4528465 0.2289417 0.20023333 0.2310000 0.03076667 0.559157467 0.002638021 FALSE TRUE
ENST00000626055 ENSG00000197894 HEK293_OSMI2_2hA HEK293_TMG_2hB ADH5 protein_coding protein_coding 78.19651 46.58327 109.0667 12.0846 1.647484 1.22715 25.709877 17.817726 31.42127 4.4938635 1.018835 0.8180778 0.3502375 0.38320000 0.2879333 -0.09526667 0.002638021 0.002638021 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197894 E001 508.7400710 9.845230e-03 2.283256e-01 3.604303e-01 4 99070978 99072151 1174 - 2.719 2.667 -0.171
ENSG00000197894 E002 47.6671703 6.582897e-04 8.153732e-01 8.830989e-01 4 99072152 99072185 34 - 1.691 1.684 -0.024
ENSG00000197894 E003 540.2426573 3.997523e-03 1.843151e-02 4.808044e-02 4 99072186 99072441 256 - 2.701 2.765 0.211
ENSG00000197894 E004 7.9910501 2.991618e-02 6.755318e-03 2.058807e-02 4 99072442 99072572 131 - 0.776 1.117 1.283
ENSG00000197894 E005 641.3079923 1.532072e-04 4.078990e-06 2.959944e-05 4 99072573 99072711 139 - 2.779 2.850 0.235
ENSG00000197894 E006 1.1749974 1.188945e-02 1.583469e-01 2.729281e-01 4 99074913 99074913 1 - 0.425 0.160 -1.892
ENSG00000197894 E007 663.1065203 9.526462e-05 3.014588e-03 1.030825e-02 4 99074914 99075049 136 - 2.804 2.849 0.150
ENSG00000197894 E008 16.9562773 2.720669e-03 7.882225e-05 4.223868e-04 4 99075225 99076291 1067 - 1.358 0.977 -1.359
ENSG00000197894 E009 613.7479122 1.117998e-04 3.122416e-02 7.433551e-02 4 99076292 99076391 100 - 2.774 2.809 0.117
ENSG00000197894 E010 448.2729031 8.721397e-04 6.684005e-02 1.381224e-01 4 99076392 99076434 43 - 2.634 2.674 0.131
ENSG00000197894 E011 641.0264076 1.307077e-04 1.390028e-01 2.467201e-01 4 99076435 99076552 118 - 2.797 2.822 0.083
ENSG00000197894 E012 489.0953988 1.751731e-04 6.686822e-01 7.756287e-01 4 99076704 99076796 93 - 2.691 2.687 -0.012
ENSG00000197894 E013 437.4614098 1.638391e-04 1.050037e-01 1.981022e-01 4 99076797 99076852 56 - 2.651 2.625 -0.085
ENSG00000197894 E014 516.6200762 1.406466e-04 9.092956e-04 3.646634e-03 4 99076853 99076923 71 - 2.732 2.681 -0.172
ENSG00000197894 E015 2.4055547 6.141180e-03 1.600100e-01 2.751339e-01 4 99079820 99079991 172 - 0.611 0.369 -1.200
ENSG00000197894 E016 0.9243042 1.438566e-02 4.572989e-01 5.976483e-01 4 99079992 99080023 32 - 0.233 0.369 0.914
ENSG00000197894 E017 3.8028209 1.061753e-02 1.468213e-02 3.977245e-02 4 99080449 99080725 277 - 0.496 0.860 1.552
ENSG00000197894 E018 460.1044843 1.333201e-04 2.341475e-03 8.280944e-03 4 99081365 99081420 56 - 2.681 2.631 -0.166
ENSG00000197894 E019 383.9945161 1.302033e-04 2.816541e-01 4.215733e-01 4 99081421 99081452 32 - 2.591 2.574 -0.056
ENSG00000197894 E020 0.0000000       4 99081674 99081918 245 -      
ENSG00000197894 E021 2.2218758 6.673214e-03 7.758419e-04 3.172136e-03 4 99081919 99081974 56 - 0.658 0.000 -11.887
ENSG00000197894 E022 385.4197165 1.412785e-04 9.070761e-04 3.638699e-03 4 99081975 99082001 27 - 2.608 2.548 -0.198
ENSG00000197894 E023 544.0371131 2.290525e-04 2.803780e-03 9.686479e-03 4 99082002 99082116 115 - 2.753 2.703 -0.163
ENSG00000197894 E024 363.2530792 1.013913e-03 1.493593e-01 2.607841e-01 4 99085115 99085216 102 - 2.573 2.532 -0.136
ENSG00000197894 E025 1.0717687 9.667940e-02 2.938988e-01 4.349558e-01 4 99085414 99085633 220 - 0.384 0.161 -1.667
ENSG00000197894 E026 177.8892063 8.167276e-03 9.509411e-01 9.733156e-01 4 99088689 99088801 113 - 2.257 2.224 -0.110