ENSG00000197879

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361007 ENSG00000197879 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO1C protein_coding protein_coding 27.24635 43.38814 19.91227 2.57142 0.3351636 -1.123251 15.5048936 22.38401 11.340940 3.435732 0.27276597 -0.9803014 0.5811542 0.5103 0.57033333 0.06003333 7.070540e-01 8.679977e-31 FALSE TRUE
ENST00000574308 ENSG00000197879 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO1C protein_coding retained_intron 27.24635 43.38814 19.91227 2.57142 0.3351636 -1.123251 0.8371631 0.00000 1.413889 0.000000 0.06644674 7.1536927 0.0387375 0.0000 0.07113333 0.07113333 8.679977e-31 8.679977e-31 FALSE FALSE
ENST00000648446 ENSG00000197879 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO1C protein_coding protein_coding 27.24635 43.38814 19.91227 2.57142 0.3351636 -1.123251 9.1669273 19.80149 5.413645 1.362212 0.46764901 -1.8690029 0.3041375 0.4622 0.27126667 -0.19093333 3.069192e-02 8.679977e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197879 E001 22.5654525 0.0016407145 5.364591e-03 1.692122e-02 17 1464186 1464211 26 - 1.095 1.365 0.956
ENSG00000197879 E002 823.8679737 0.0095810200 1.943690e-06 1.516145e-05 17 1464212 1464841 630 - 2.650 2.900 0.834
ENSG00000197879 E003 348.1919902 0.0009417951 8.404499e-08 8.660831e-07 17 1464842 1465016 175 - 2.347 2.511 0.545
ENSG00000197879 E004 593.9766314 0.0025321262 2.496887e-07 2.349047e-06 17 1465017 1465374 358 - 2.571 2.744 0.575
ENSG00000197879 E005 176.7842181 0.0023955272 2.632007e-06 1.995271e-05 17 1465375 1465412 38 - 2.013 2.223 0.705
ENSG00000197879 E006 471.6880504 0.0010361151 2.989043e-04 1.375231e-03 17 1465413 1465752 340 - 2.522 2.629 0.357
ENSG00000197879 E007 231.4990667 0.0010421546 4.484561e-01 5.897450e-01 17 1467242 1467327 86 - 2.267 2.308 0.137
ENSG00000197879 E008 159.8565157 0.0006295892 2.787516e-01 4.184189e-01 17 1467328 1467341 14 - 2.098 2.152 0.181
ENSG00000197879 E009 163.9953205 0.0006159274 2.888404e-01 4.294803e-01 17 1467480 1467490 11 - 2.108 2.161 0.177
ENSG00000197879 E010 255.1591156 0.0007958582 2.057946e-01 3.334117e-01 17 1467491 1467577 87 - 2.299 2.353 0.180
ENSG00000197879 E011 232.6254362 0.0030277074 2.473410e-01 3.828116e-01 17 1467840 1467910 71 - 2.254 2.316 0.208
ENSG00000197879 E012 304.5030976 0.0011853834 3.013977e-02 7.224233e-02 17 1467988 1468123 136 - 2.352 2.433 0.270
ENSG00000197879 E013 3.2643834 0.0141445709 1.009520e-06 8.365066e-06 17 1468223 1468252 30 - 0.993 0.259 -3.439
ENSG00000197879 E014 168.5588351 0.0002672740 3.933325e-02 8.978873e-02 17 1468253 1468308 56 - 2.092 2.176 0.281
ENSG00000197879 E015 6.2629826 0.0245342537 9.912208e-07 8.229635e-06 17 1468309 1468402 94 - 1.192 0.536 -2.579
ENSG00000197879 E016 204.8332993 0.0009082738 1.394661e-04 7.012538e-04 17 1468403 1468496 94 - 2.129 2.273 0.481
ENSG00000197879 E017 1.1749062 0.0107799110 4.130322e-01 5.565760e-01 17 1468497 1468499 3 - 0.182 0.347 1.232
ENSG00000197879 E018 4.7888696 0.0034545224 4.282149e-06 3.092678e-05 17 1468790 1469530 741 - 1.076 0.482 -2.423
ENSG00000197879 E019 206.5093720 0.0047413997 8.816092e-02 1.723223e-01 17 1469531 1469614 84 - 2.173 2.270 0.324
ENSG00000197879 E020 184.1364748 0.0002214054 2.576321e-01 3.948007e-01 17 1470175 1470239 65 - 2.158 2.210 0.172
ENSG00000197879 E021 200.9309199 0.0003096007 9.463293e-02 1.823315e-01 17 1470240 1470334 95 - 2.183 2.250 0.224
ENSG00000197879 E022 193.2792581 0.0002017286 8.599716e-01 9.136945e-01 17 1470435 1470519 85 - 2.210 2.221 0.038
ENSG00000197879 E023 118.6706902 0.0002918267 1.542545e-01 2.674567e-01 17 1470621 1470630 10 - 2.036 2.000 -0.120
ENSG00000197879 E024 181.3664304 0.0011695398 2.998126e-01 4.413971e-01 17 1470631 1470689 59 - 2.203 2.186 -0.056
ENSG00000197879 E025 0.8846520 0.0135857145 4.724654e-03 1.516222e-02 17 1470690 1470787 98 - 0.556 0.080 -3.675
ENSG00000197879 E026 201.0842166 0.0025889985 3.334457e-01 4.771710e-01 17 1471071 1471133 63 - 2.247 2.232 -0.051
ENSG00000197879 E027 129.1470836 0.0006510398 3.315942e-01 4.752359e-01 17 1471134 1471147 14 - 2.056 2.038 -0.062
ENSG00000197879 E028 220.6053246 0.0001744454 2.306969e-01 3.632838e-01 17 1471223 1471336 114 - 2.288 2.272 -0.053
ENSG00000197879 E029 209.6820105 0.0001810042 1.441786e-01 2.536892e-01 17 1471907 1472024 118 - 2.272 2.248 -0.080
ENSG00000197879 E030 189.0642433 0.0002429904 6.500679e-02 1.350455e-01 17 1472123 1472228 106 - 2.236 2.198 -0.125
ENSG00000197879 E031 0.5202097 0.0206171506 1.609879e-01 2.764113e-01 17 1472229 1472355 127 - 0.310 0.081 -2.350
ENSG00000197879 E032 190.5969589 0.0002083783 3.254486e-02 7.689030e-02 17 1474610 1474690 81 - 2.249 2.203 -0.151
ENSG00000197879 E033 191.1021882 0.0001832366 3.450736e-02 8.072853e-02 17 1474812 1474858 47 - 2.247 2.203 -0.148
ENSG00000197879 E034 1.0987209 0.0164768990 7.537588e-01 8.395830e-01 17 1474859 1474931 73 - 0.310 0.259 -0.348
ENSG00000197879 E035 224.5394941 0.0001896230 4.322698e-04 1.898510e-03 17 1474938 1475032 95 - 2.341 2.265 -0.255
ENSG00000197879 E036 1.0234925 0.0151675227 7.525857e-01 8.387314e-01 17 1477290 1477504 215 - 0.310 0.259 -0.351
ENSG00000197879 E037 215.2353246 0.0002489114 5.310311e-06 3.756759e-05 17 1477505 1477596 92 - 2.343 2.237 -0.354
ENSG00000197879 E038 177.2305425 0.0002183687 1.996603e-03 7.215628e-03 17 1477891 1477971 81 - 2.237 2.162 -0.252
ENSG00000197879 E039 143.4744231 0.0002472232 3.532998e-03 1.182098e-02 17 1478087 1478192 106 - 2.147 2.067 -0.267
ENSG00000197879 E040 141.4385044 0.0013232886 9.069821e-02 1.762308e-01 17 1478410 1478492 83 - 2.119 2.074 -0.151
ENSG00000197879 E041 148.6844500 0.0015767402 1.421063e-01 2.508981e-01 17 1478616 1478676 61 - 2.136 2.099 -0.123
ENSG00000197879 E042 162.7449825 0.0013009486 6.798909e-03 2.070027e-02 17 1478677 1478735 59 - 2.202 2.125 -0.255
ENSG00000197879 E043 169.1056144 0.0005296599 1.162097e-02 3.262970e-02 17 1479431 1479502 72 - 2.207 2.144 -0.210
ENSG00000197879 E044 202.9856936 0.0006003899 3.818341e-06 2.791115e-05 17 1479592 1479685 94 - 2.324 2.207 -0.391
ENSG00000197879 E045 121.1156700 0.0005249531 1.056316e-06 8.722310e-06 17 1479686 1479705 20 - 2.131 1.973 -0.528
ENSG00000197879 E046 197.1562862 0.0065983335 8.471298e-03 2.496470e-02 17 1480527 1480606 80 - 2.308 2.202 -0.355
ENSG00000197879 E047 121.3494874 0.0033085304 1.604764e-02 4.284232e-02 17 1480607 1480625 19 - 2.085 1.997 -0.297
ENSG00000197879 E048 247.6468993 0.0015454997 5.344971e-04 2.288905e-03 17 1480706 1480885 180 - 2.391 2.303 -0.291
ENSG00000197879 E049 0.2965864 0.2948217255 7.220844e-01   17 1480886 1480984 99 - 0.000 0.145 10.886
ENSG00000197879 E050 0.0000000       17 1480985 1481158 174 -      
ENSG00000197879 E051 0.0000000       17 1481159 1481238 80 -      
ENSG00000197879 E052 104.7005221 0.0016055217 1.053245e-01 1.985862e-01 17 1482478 1482488 11 - 1.992 1.941 -0.172
ENSG00000197879 E053 128.3112457 0.0036423084 1.493269e-02 4.033296e-02 17 1482489 1482532 44 - 2.108 2.020 -0.297
ENSG00000197879 E054 100.1563648 0.0043453152 4.305156e-03 1.399809e-02 17 1482533 1482558 26 - 2.025 1.904 -0.407
ENSG00000197879 E055 91.3506012 0.0086387522 5.702172e-04 2.422324e-03 17 1482861 1482888 28 - 2.030 1.846 -0.616
ENSG00000197879 E056 209.6226759 0.0059290577 5.628721e-04 2.395310e-03 17 1482889 1483059 171 - 2.354 2.220 -0.446
ENSG00000197879 E057 167.7718708 0.0026325319 1.057792e-04 5.485782e-04 17 1483610 1483725 116 - 2.252 2.124 -0.430
ENSG00000197879 E058 151.5640881 0.0068321343 2.497817e-02 6.182924e-02 17 1484148 1484303 156 - 2.181 2.092 -0.300
ENSG00000197879 E059 0.3666179 0.0302824760 4.782505e-01 6.166855e-01 17 1484590 1484657 68 - 0.182 0.081 -1.348
ENSG00000197879 E060 0.2924217 0.0271703015 4.390198e-02   17 1485122 1485367 246 - 0.310 0.000 -13.905
ENSG00000197879 E061 12.8638698 0.0299550939 9.053280e-01 9.437184e-01 17 1485694 1485762 69 - 1.076 1.081 0.017
ENSG00000197879 E062 0.4031496 0.0244430894 6.224287e-01 7.392236e-01 17 1486055 1486201 147 - 0.000 0.149 10.930
ENSG00000197879 E063 0.1817044 0.0396323482 1.000000e+00   17 1486880 1486951 72 - 0.000 0.081 9.928
ENSG00000197879 E064 3.6627065 0.0500093543 5.924795e-01 7.150221e-01 17 1486952 1487098 147 - 0.666 0.589 -0.334
ENSG00000197879 E065 2.0744469 0.3237254143 4.216934e-01 5.648311e-01 17 1490928 1491237 310 - 0.617 0.379 -1.175
ENSG00000197879 E066 41.1936380 0.0101673757 2.570351e-01 3.940770e-01 17 1491600 1491682 83 - 1.602 1.537 -0.220
ENSG00000197879 E067 0.4428904 0.4639966155 7.606095e-01 8.446505e-01 17 1492010 1492040 31 - 0.000 0.155 11.006
ENSG00000197879 E068 0.6632043 0.0218189541 9.336974e-01 9.622269e-01 17 1492413 1492686 274 - 0.182 0.207 0.232