ENSG00000197841

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000448715 ENSG00000197841 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF181 protein_coding retained_intron 1.698525 0.4246167 2.876157 0.03445856 0.3408214 2.731334 0.05965658 0.00000000 0.16685703 0.00000000 0.02442767 4.144512 0.04874583 0.0000000 0.05933333 0.05933333 0.2524850941 0.0009841209 FALSE TRUE
ENST00000459757 ENSG00000197841 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF181 protein_coding protein_coding 1.698525 0.4246167 2.876157 0.03445856 0.3408214 2.731334 0.03194716 0.00000000 0.17999049 0.00000000 0.17999049 4.247855 0.01808333 0.0000000 0.05293333 0.05293333 1.0000000000 0.0009841209 FALSE TRUE
ENST00000492450 ENSG00000197841 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF181 protein_coding protein_coding 1.698525 0.4246167 2.876157 0.03445856 0.3408214 2.731334 0.37714315 0.13587128 0.28358665 0.03688108 0.03816477 1.009091 0.24394583 0.3147667 0.10326667 -0.21150000 0.0632020886 0.0009841209 FALSE TRUE
ENST00000593781 ENSG00000197841 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF181 protein_coding protein_coding 1.698525 0.4246167 2.876157 0.03445856 0.3408214 2.731334 0.16982635 0.00000000 0.60901322 0.00000000 0.04933958 5.951898 0.08264167 0.0000000 0.21383333 0.21383333 0.0012688971 0.0009841209 FALSE TRUE
ENST00000595708 ENSG00000197841 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF181 protein_coding protein_coding 1.698525 0.4246167 2.876157 0.03445856 0.3408214 2.731334 0.02137935 0.08043358 0.00000000 0.08043358 0.00000000 -3.176859 0.05870417 0.2188000 0.00000000 -0.21880000 0.5046960217 0.0009841209 FALSE TRUE
ENST00000599244 ENSG00000197841 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF181 protein_coding protein_coding 1.698525 0.4246167 2.876157 0.03445856 0.3408214 2.731334 0.43375996 0.00000000 1.17034291 0.00000000 0.35181838 6.883062 0.16148333 0.0000000 0.38893333 0.38893333 0.0009841209 0.0009841209   FALSE
MSTRG.16959.1 ENSG00000197841 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF181 protein_coding   1.698525 0.4246167 2.876157 0.03445856 0.3408214 2.731334 0.18054688 0.20831185 0.02414191 0.08034185 0.02414191 -2.676775 0.16323333 0.4664000 0.01080000 -0.45560000 0.0019395098 0.0009841209 FALSE TRUE
MSTRG.16959.2 ENSG00000197841 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF181 protein_coding   1.698525 0.4246167 2.876157 0.03445856 0.3408214 2.731334 0.39831971 0.00000000 0.32391909 0.00000000 0.18746977 5.061427 0.20384167 0.0000000 0.13270000 0.13270000 0.6190456871 0.0009841209 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197841 E001 0.000000       19 34734155 34734155 1 +      
ENSG00000197841 E002 0.000000       19 34734156 34734193 38 +      
ENSG00000197841 E003 2.029459 0.0082734967 0.70109099 0.80039282 19 34734194 34734242 49 + 0.443 0.365 -0.428
ENSG00000197841 E004 2.029459 0.0082734967 0.70109099 0.80039282 19 34734243 34734245 3 + 0.443 0.365 -0.428
ENSG00000197841 E005 2.623766 0.0205970977 0.84469371 0.90335426 19 34734246 34734255 10 + 0.512 0.473 -0.191
ENSG00000197841 E006 3.108501 0.0191711521 0.95695404 0.97699974 19 34734256 34734262 7 + 0.553 0.560 0.031
ENSG00000197841 E007 6.215971 0.0027455335 0.99548964 1.00000000 19 34734263 34734310 48 + 0.800 0.797 -0.015
ENSG00000197841 E008 7.659442 0.0036881578 0.99953085 1.00000000 19 34734311 34734360 50 + 0.881 0.879 -0.007
ENSG00000197841 E009 3.095726 0.0051176390 0.03628941 0.08413805 19 34734361 34734574 214 + 0.467 0.796 1.444
ENSG00000197841 E010 4.800703 0.0036594921 0.29031025 0.43110307 19 34734575 34734969 395 + 0.741 0.560 -0.777
ENSG00000197841 E011 8.883469 0.0025765619 0.22352182 0.35459632 19 34734970 34735046 77 + 0.964 0.797 -0.642
ENSG00000197841 E012 1.035237 0.0673960871 0.19337304 0.31801402 19 34736075 34736206 132 + 0.328 0.000 -10.139
ENSG00000197841 E013 13.196705 0.0014016445 0.25451189 0.39120587 19 34739148 34739268 121 + 1.111 0.980 -0.479
ENSG00000197841 E014 1.035123 0.0121989077 0.16977027 0.28790780 19 34739269 34739522 254 + 0.328 0.000 -10.289
ENSG00000197841 E015 3.786786 0.0084569797 0.11207811 0.20858765 19 34739523 34739525 3 + 0.672 0.365 -1.493
ENSG00000197841 E016 13.223784 0.0013465174 0.82771204 0.89169683 19 34739526 34739609 84 + 1.089 1.062 -0.099
ENSG00000197841 E017 5.320925 0.0031407903 0.41769492 0.56102213 19 34739610 34739621 12 + 0.766 0.632 -0.554
ENSG00000197841 E018 119.034963 0.0004064659 0.02991539 0.07179443 19 34740611 34745378 4768 + 1.992 2.040 0.161