ENSG00000197837

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358064 ENSG00000197837 HEK293_OSMI2_2hA HEK293_TMG_2hB H4-16 protein_coding nonsense_mediated_decay 1.213129 1.515317 0.7563874 0.09425391 0.1914114 -0.9929635 0.1177725 0.00000000 0.1874310 0.00000000 0.03027175 4.3032765 0.16636250 0.00000000 0.2815000 0.28150000 3.977064e-05 3.977064e-05 TRUE FALSE
ENST00000537096 ENSG00000197837 HEK293_OSMI2_2hA HEK293_TMG_2hB H4-16 protein_coding processed_transcript 1.213129 1.515317 0.7563874 0.09425391 0.1914114 -0.9929635 0.1023363 0.11375192 0.0000000 0.11375192 0.00000000 -3.6293790 0.07587500 0.06726667 0.0000000 -0.06726667 8.873874e-01 3.977064e-05   FALSE
ENST00000537853 ENSG00000197837 HEK293_OSMI2_2hA HEK293_TMG_2hB H4-16 protein_coding processed_transcript 1.213129 1.515317 0.7563874 0.09425391 0.1914114 -0.9929635 0.3248569 0.38397751 0.2415146 0.12186114 0.12758856 -0.6474709 0.29542083 0.24663333 0.2987667 0.05213333 1.000000e+00 3.977064e-05   FALSE
ENST00000539745 ENSG00000197837 HEK293_OSMI2_2hA HEK293_TMG_2hB H4-16 protein_coding protein_coding 1.213129 1.515317 0.7563874 0.09425391 0.1914114 -0.9929635 0.5345215 0.76094791 0.3274418 0.11763575 0.19503012 -1.1919949 0.34152500 0.51450000 0.4197333 -0.09476667 8.960406e-01 3.977064e-05 FALSE FALSE
ENST00000540565 ENSG00000197837 HEK293_OSMI2_2hA HEK293_TMG_2hB H4-16 protein_coding processed_transcript 1.213129 1.515317 0.7563874 0.09425391 0.1914114 -0.9929635 0.0899099 0.18599709 0.0000000 0.05067260 0.00000000 -4.2927603 0.07412917 0.12156667 0.0000000 -0.12156667 9.655206e-03 3.977064e-05 TRUE FALSE
ENST00000541592 ENSG00000197837 HEK293_OSMI2_2hA HEK293_TMG_2hB H4-16 protein_coding processed_transcript 1.213129 1.515317 0.7563874 0.09425391 0.1914114 -0.9929635 0.0437318 0.07064268 0.0000000 0.03757893 0.00000000 -3.0115435 0.04667083 0.05000000 0.0000000 -0.05000000 3.241156e-01 3.977064e-05   TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197837 E001 0.1451727 0.048124082 0.462371501   12 14767999 14768157 159 - 0.134 0.000 -10.977
ENSG00000197837 E002 0.1451727 0.048124082 0.462371501   12 14768158 14768201 44 - 0.134 0.000 -12.950
ENSG00000197837 E003 1.0457324 0.013950256 0.002635635 0.009176358 12 14768202 14768924 723 - 0.547 0.000 -14.895
ENSG00000197837 E004 0.4502799 0.025531669 0.075249843 0.151934445 12 14768925 14768938 14 - 0.318 0.000 -14.114
ENSG00000197837 E005 2.7731136 0.006451638 0.713966762 0.810311769 12 14768939 14768995 57 - 0.628 0.525 -0.464
ENSG00000197837 E006 2.1788069 0.007529241 0.848352028 0.905822508 12 14768996 14769009 14 - 0.500 0.485 -0.071
ENSG00000197837 E007 2.1935702 0.009308128 0.515530697 0.650190358 12 14769010 14769294 285 - 0.589 0.441 -0.712
ENSG00000197837 E008 1.8832516 0.009288801 0.823684021 0.888924461 12 14769295 14769457 163 - 0.447 0.442 -0.030
ENSG00000197837 E009 0.8115992 0.018090557 0.611547278 0.730651765 12 14769458 14769463 6 - 0.318 0.201 -0.879
ENSG00000197837 E010 0.2214452 0.040974256 0.508641018   12 14769464 14769622 159 - 0.000 0.112 11.205
ENSG00000197837 E011 3.5105140 0.005042349 0.569370313 0.695933376 12 14769900 14770276 377 - 0.628 0.656 0.121
ENSG00000197837 E012 2.4606446 0.008701039 0.487776779 0.625417346 12 14770679 14770719 41 - 0.500 0.562 0.290
ENSG00000197837 E013 7.0665701 0.003318309 0.080562661 0.160436817 12 14770720 14771131 412 - 0.830 0.951 0.460