ENSG00000197822

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396442 ENSG00000197822 HEK293_OSMI2_2hA HEK293_TMG_2hB OCLN protein_coding protein_coding 4.022862 1.835799 5.245241 0.2254931 0.2625781 1.509512 3.11407038 0.9148887 4.09978312 0.23085813 0.23688853 2.151711 0.70030000 0.52250000 0.78183333 0.25933333 0.3499019730 0.0007168975 FALSE  
ENST00000514370 ENSG00000197822 HEK293_OSMI2_2hA HEK293_TMG_2hB OCLN protein_coding processed_transcript 4.022862 1.835799 5.245241 0.2254931 0.2625781 1.509512 0.04993263 0.2456137 0.00000000 0.24561371 0.00000000 -4.675893 0.02319583 0.10843333 0.00000000 -0.10843333 0.5658527052 0.0007168975 FALSE  
ENST00000538151 ENSG00000197822 HEK293_OSMI2_2hA HEK293_TMG_2hB OCLN protein_coding protein_coding 4.022862 1.835799 5.245241 0.2254931 0.2625781 1.509512 0.08908544 0.3090703 0.01014539 0.30907033 0.01014539 -3.985353 0.04645000 0.17756667 0.00180000 -0.17576667 0.7532754519 0.0007168975 FALSE  
ENST00000680098 ENSG00000197822 HEK293_OSMI2_2hA HEK293_TMG_2hB OCLN protein_coding protein_coding 4.022862 1.835799 5.245241 0.2254931 0.2625781 1.509512 0.16771408 0.1427452 0.17783299 0.02424911 0.05726902 0.298323 0.06833333 0.08116667 0.03426667 -0.04690000 0.2697195096 0.0007168975 FALSE  
MSTRG.26315.3 ENSG00000197822 HEK293_OSMI2_2hA HEK293_TMG_2hB OCLN protein_coding   4.022862 1.835799 5.245241 0.2254931 0.2625781 1.509512 0.18490285 0.0000000 0.45166608 0.00000000 0.09839505 5.528778 0.04100417 0.00000000 0.08573333 0.08573333 0.0007168975 0.0007168975 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197822 E001 2.0744113 0.0068193859 7.415015e-01 8.306541e-01 5 69492292 69492659 368 + 0.444 0.385 -0.320
ENSG00000197822 E002 0.5911862 0.0184808235 5.212498e-01 6.551299e-01 5 69492773 69492777 5 + 0.202 0.000 -9.641
ENSG00000197822 E003 1.6369186 0.0087407821 8.059722e-02 1.604854e-01 5 69492778 69492789 12 + 0.420 0.000 -10.915
ENSG00000197822 E004 4.7592524 0.0094237987 6.318953e-02 1.320188e-01 5 69492790 69492800 11 + 0.737 0.385 -1.643
ENSG00000197822 E005 13.2198643 0.0013433395 3.133214e-03 1.065689e-02 5 69492801 69492840 40 + 1.119 0.723 -1.507
ENSG00000197822 E006 16.5207819 0.0012031437 1.642551e-03 6.097075e-03 5 69492841 69492876 36 + 1.208 0.827 -1.406
ENSG00000197822 E007 17.6937030 0.0010103803 1.687829e-03 6.244099e-03 5 69492877 69492900 24 + 1.235 0.871 -1.332
ENSG00000197822 E008 0.1515154 0.0430420302 1.000000e+00   5 69493552 69493672 121 + 0.060 0.000 -7.740
ENSG00000197822 E009 0.0000000       5 69493673 69493693 21 +      
ENSG00000197822 E010 0.0000000       5 69493694 69494005 312 +      
ENSG00000197822 E011 0.0000000       5 69494006 69494035 30 +      
ENSG00000197822 E012 37.5756241 0.0006284653 2.861702e-04 1.323618e-03 5 69504177 69504294 118 + 1.538 1.258 -0.969
ENSG00000197822 E013 56.7790609 0.0005021469 1.039711e-03 4.096545e-03 5 69509141 69509388 248 + 1.702 1.510 -0.654
ENSG00000197822 E014 43.7227296 0.0004937576 7.884477e-02 1.576720e-01 5 69509389 69509621 233 + 1.579 1.470 -0.372
ENSG00000197822 E015 37.1491454 0.0006573085 4.041618e-01 5.478677e-01 5 69509622 69509819 198 + 1.499 1.449 -0.173
ENSG00000197822 E016 34.8799750 0.0087291060 9.628397e-01 9.805199e-01 5 69513948 69514109 162 + 1.461 1.471 0.034
ENSG00000197822 E017 0.8094222 0.1810974582 2.844271e-01 4.246671e-01 5 69519983 69520101 119 + 0.160 0.386 1.686
ENSG00000197822 E018 5.4005859 0.0035304946 4.645850e-08 5.044085e-07 5 69520102 69521815 1714 + 0.467 1.184 2.887
ENSG00000197822 E019 24.0213970 0.0009293989 5.756834e-01 7.012188e-01 5 69534694 69534839 146 + 1.294 1.351 0.196
ENSG00000197822 E020 0.0000000       5 69544692 69544743 52 +      
ENSG00000197822 E021 0.0000000       5 69544744 69544789 46 +      
ENSG00000197822 E022 0.0000000       5 69544790 69544903 114 +      
ENSG00000197822 E023 13.3763220 0.0013007663 1.078835e-01 2.024006e-01 5 69544904 69544961 58 + 1.099 0.911 -0.697
ENSG00000197822 E024 32.6401121 0.0007024721 1.149553e-01 2.127771e-01 5 69544962 69545119 158 + 1.452 1.337 -0.399
ENSG00000197822 E025 31.5986580 0.0007082272 3.320377e-01 4.756592e-01 5 69547930 69548101 172 + 1.431 1.364 -0.231
ENSG00000197822 E026 0.8544736 0.0158656229 3.549839e-02 8.261140e-02 5 69549380 69551543 2164 + 0.113 0.497 2.851
ENSG00000197822 E027 18.7393511 0.0012797476 8.845008e-01 9.301725e-01 5 69551544 69551585 42 + 1.200 1.223 0.081
ENSG00000197822 E028 112.9310763 0.0011776190 2.290385e-20 1.525155e-18 5 69553570 69558104 4535 + 1.879 2.201 1.082