ENSG00000197818

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361573 ENSG00000197818 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC9A8 protein_coding protein_coding 4.154735 4.569322 3.724121 0.2573275 0.07316334 -0.2943653 1.6274638 1.9273342 1.99721307 0.24331484 0.18643125 0.05112095 0.3972333 0.4238000 0.53533333 0.1115333 0.46693229 0.03919401 FALSE TRUE
ENST00000490250 ENSG00000197818 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC9A8 protein_coding processed_transcript 4.154735 4.569322 3.724121 0.2573275 0.07316334 -0.2943653 0.8308636 1.0159457 0.44328318 0.08380934 0.04682233 -1.17846980 0.1853500 0.2232667 0.11943333 -0.1038333 0.03919401 0.03919401   FALSE
MSTRG.20828.3 ENSG00000197818 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC9A8 protein_coding   4.154735 4.569322 3.724121 0.2573275 0.07316334 -0.2943653 1.3730851 0.9011376 1.19929971 0.50792921 0.17193057 0.40843101 0.3375542 0.2006000 0.32236667 0.1217667 0.70332481 0.03919401 FALSE TRUE
MSTRG.20828.4 ENSG00000197818 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC9A8 protein_coding   4.154735 4.569322 3.724121 0.2573275 0.07316334 -0.2943653 0.2161399 0.6210464 0.06723047 0.29922588 0.03524092 -3.03050410 0.0546250 0.1307667 0.01843333 -0.1123333 0.09795805 0.03919401 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197818 E001 0.5514428 0.0196655836 1.274832e-01 0.2306517973 20 49812713 49812827 115 + 0.000 0.286 10.572
ENSG00000197818 E002 2.3906872 0.0062694452 5.371750e-01 0.6688104030 20 49812828 49812891 64 + 0.432 0.580 0.716
ENSG00000197818 E003 2.6873753 0.0056745862 9.892803e-01 0.9973187335 20 49812892 49812892 1 + 0.530 0.580 0.230
ENSG00000197818 E004 2.9871839 0.0051994796 9.636933e-01 0.9810984886 20 49812893 49812893 1 + 0.571 0.614 0.189
ENSG00000197818 E005 12.7744224 0.0156094904 5.829422e-02 0.1237025005 20 49812894 49812948 55 + 1.213 1.074 -0.499
ENSG00000197818 E006 25.4342869 0.0111965186 4.590210e-02 0.1018607635 20 49815008 49815189 182 + 1.472 1.375 -0.335
ENSG00000197818 E007 0.1515154 0.0434503953 3.883839e-01   20 49815190 49815444 255 + 0.127 0.000 -11.698
ENSG00000197818 E008 19.1716439 0.0013716145 3.963369e-01 0.5401125898 20 49823061 49823141 81 + 1.303 1.300 -0.009
ENSG00000197818 E009 16.7274415 0.0015841981 9.897607e-01 0.9976747035 20 49839541 49839599 59 + 1.204 1.265 0.216
ENSG00000197818 E010 18.0787269 0.0194081569 6.039880e-01 0.7246548293 20 49845036 49845119 84 + 1.204 1.317 0.399
ENSG00000197818 E011 24.8873819 0.0418611795 7.847357e-01 0.8619608011 20 49849579 49849680 102 + 1.351 1.442 0.314
ENSG00000197818 E012 1.3618841 0.2465454318 9.549689e-01 0.9757607827 20 49850762 49850809 48 + 0.373 0.355 -0.104
ENSG00000197818 E013 12.2187280 0.0952128409 8.610270e-01 0.9143720885 20 49850810 49850844 35 + 1.111 1.111 0.000
ENSG00000197818 E014 30.5456089 0.0283554938 6.315094e-01 0.7464983799 20 49855438 49855581 144 + 1.481 1.495 0.046
ENSG00000197818 E015 27.0807950 0.0007497062 1.878887e-01 0.3110844016 20 49862929 49863067 139 + 1.451 1.428 -0.079
ENSG00000197818 E016 24.4740870 0.0009644638 1.405146e-01 0.2487477363 20 49864739 49864844 106 + 1.419 1.380 -0.132
ENSG00000197818 E017 27.5750633 0.0019609283 5.541061e-02 0.1186900922 20 49874705 49874821 117 + 1.486 1.423 -0.218
ENSG00000197818 E018 24.4273762 0.0070082426 2.407605e-01 0.3750655677 20 49877981 49878063 83 + 1.413 1.387 -0.092
ENSG00000197818 E019 30.6794424 0.0007258629 2.481744e-02 0.0614996816 20 49880924 49881035 112 + 1.532 1.457 -0.256
ENSG00000197818 E020 52.2693675 0.0004327717 6.062651e-05 0.0003345522 20 49883846 49884066 221 + 1.785 1.661 -0.422
ENSG00000197818 E021 11.7515406 0.0651862770 4.221876e-01 0.5653489451 20 49886371 49886751 381 + 1.112 1.077 -0.127
ENSG00000197818 E022 46.2673506 0.0006046560 6.099955e-04 0.0025695822 20 49886752 49886898 147 + 1.728 1.620 -0.366
ENSG00000197818 E023 509.5488713 0.0075809802 6.713636e-05 0.0003662927 20 49887829 49892307 4479 + 2.605 2.765 0.535