ENSG00000197808

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360357 ENSG00000197808 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF461 protein_coding protein_coding 2.944489 0.5861821 4.26527 0.1612625 0.2471388 2.842191 0.37501564 0.15350188 0.36760819 0.09313189 0.13439652 1.207583 0.14695833 0.24560000 0.088866667 -0.15673333 0.6981226995 0.0004519822 FALSE TRUE
ENST00000540605 ENSG00000197808 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF461 protein_coding processed_transcript 2.944489 0.5861821 4.26527 0.1612625 0.2471388 2.842191 0.02223099 0.04934717 0.01620391 0.04934717 0.01620391 -1.179397 0.01593750 0.08883333 0.004266667 -0.08456667 0.5348427378 0.0004519822 FALSE TRUE
ENST00000588268 ENSG00000197808 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF461 protein_coding protein_coding 2.944489 0.5861821 4.26527 0.1612625 0.2471388 2.842191 0.42208015 0.19913457 0.54314789 0.06877689 0.16100331 1.403234 0.19791250 0.45616667 0.132800000 -0.32336667 0.5890034684 0.0004519822 FALSE TRUE
ENST00000590487 ENSG00000197808 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF461 protein_coding retained_intron 2.944489 0.5861821 4.26527 0.1612625 0.2471388 2.842191 0.21360787 0.00000000 0.32674536 0.00000000 0.32674536 5.073586 0.06192083 0.00000000 0.074400000 0.07440000 1.0000000000 0.0004519822 FALSE TRUE
ENST00000592496 ENSG00000197808 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF461 protein_coding retained_intron 2.944489 0.5861821 4.26527 0.1612625 0.2471388 2.842191 0.38550032 0.11143905 0.68858311 0.11143905 0.21171163 2.524199 0.13472500 0.12670000 0.162666667 0.03596667 0.7869825879 0.0004519822   FALSE
ENST00000592829 ENSG00000197808 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF461 protein_coding protein_coding 2.944489 0.5861821 4.26527 0.1612625 0.2471388 2.842191 0.36864773 0.00000000 0.44874884 0.00000000 0.23186002 5.519633 0.11439583 0.00000000 0.099300000 0.09930000 0.5700719946 0.0004519822   FALSE
ENST00000614133 ENSG00000197808 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF461 protein_coding protein_coding 2.944489 0.5861821 4.26527 0.1612625 0.2471388 2.842191 0.71257637 0.00000000 1.41682287 0.00000000 0.37028131 7.156662 0.18872917 0.00000000 0.329100000 0.32910000 0.0004519822 0.0004519822 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197808 E001 5.6343605 0.0089585647 0.10985357 0.20534622 19 36636618 36637191 574 - 0.687 0.910 0.884
ENSG00000197808 E002 1.7830217 0.0698080724 0.42185987 0.56499793 19 36637192 36637224 33 - 0.421 0.233 -1.203
ENSG00000197808 E003 1.6325504 0.0657246579 0.92650933 0.95771498 19 36637225 36637316 92 - 0.369 0.383 0.082
ENSG00000197808 E004 1.6692976 0.0092946436 0.45954285 0.59965433 19 36637317 36637619 303 - 0.395 0.234 -1.058
ENSG00000197808 E005 6.8382752 0.0279911573 0.21335634 0.34249525 19 36637620 36638146 527 - 0.771 0.946 0.677
ENSG00000197808 E006 5.1978102 0.0495657092 0.04411960 0.09860469 19 36638147 36638532 386 - 0.631 0.945 1.254
ENSG00000197808 E007 3.7542163 0.0391698318 0.72833040 0.82081612 19 36638533 36638630 98 - 0.599 0.657 0.250
ENSG00000197808 E008 4.1928428 0.0062903306 0.69989636 0.79949631 19 36638631 36638652 22 - 0.659 0.585 -0.323
ENSG00000197808 E009 46.0392739 0.0008218701 0.33826203 0.48212313 19 36638653 36639654 1002 - 1.569 1.612 0.146
ENSG00000197808 E010 19.4354786 0.0476591995 0.17827191 0.29897104 19 36639655 36640022 368 - 1.249 1.048 -0.721
ENSG00000197808 E011 5.6079229 0.0031567697 0.29021223 0.43100144 19 36640023 36640043 21 - 0.771 0.586 -0.780
ENSG00000197808 E012 0.0000000       19 36640044 36640112 69 -      
ENSG00000197808 E013 0.3729606 0.0276831444 0.24496295 0.37998970 19 36643274 36643793 520 - 0.060 0.234 2.266
ENSG00000197808 E014 4.9188081 0.0032691138 0.05941504 0.12563624 19 36643794 36643821 28 - 0.748 0.385 -1.691
ENSG00000197808 E015 5.7208554 0.0030801095 0.51718380 0.65163078 19 36643822 36643862 41 - 0.771 0.659 -0.459
ENSG00000197808 E016 0.1451727 0.0429229541 1.00000000   19 36645152 36645220 69 - 0.060 0.000 -7.252
ENSG00000197808 E017 11.7904584 0.0193874923 0.74047247 0.82988886 19 36656448 36656543 96 - 1.033 0.979 -0.198
ENSG00000197808 E018 1.6199667 0.0091751878 0.08664547 0.17003205 19 36657653 36657750 98 - 0.420 0.001 -10.102
ENSG00000197808 E019 1.9876419 0.0072426185 0.87974644 0.92682985 19 36658092 36658298 207 - 0.421 0.385 -0.195
ENSG00000197808 E020 7.8212910 0.0022764130 0.26883485 0.40730793 19 36658299 36658335 37 - 0.894 0.722 -0.675
ENSG00000197808 E021 9.5667579 0.0020247276 0.86403940 0.91633595 19 36658336 36658425 90 - 0.933 0.947 0.051
ENSG00000197808 E022 1.1331657 0.0139686204 0.44613373 0.58766306 19 36658426 36658446 21 - 0.241 0.385 0.944
ENSG00000197808 E023 0.0000000       19 36658555 36658563 9 -      
ENSG00000197808 E024 8.1295160 0.0020326467 0.70751640 0.80542284 19 36664698 36664786 89 - 0.868 0.910 0.159
ENSG00000197808 E025 5.8659118 0.0027777372 0.50714448 0.64274649 19 36666690 36666853 164 - 0.737 0.826 0.357