ENSG00000197780

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338366 ENSG00000197780 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF13 protein_coding protein_coding 23.44933 13.96491 36.76295 2.554985 0.5256318 1.395806 15.252009 6.699258 24.88257 0.8622169 0.4621219 1.8914904 0.6163667 0.4889333 0.6767667 0.1878333 2.195377e-06 2.195377e-06 FALSE TRUE
ENST00000461096 ENSG00000197780 HEK293_OSMI2_2hA HEK293_TMG_2hB TAF13 protein_coding protein_coding 23.44933 13.96491 36.76295 2.554985 0.5256318 1.395806 7.711202 6.846267 11.46851 1.8426171 0.2562884 0.7434404 0.3602625 0.4777333 0.3118667 -0.1658667 1.009784e-02 2.195377e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197780 E001 484.3226398 0.0059784644 1.566260e-06 1.246684e-05 1 109062496 109064139 1644 - 2.590 2.785 0.647
ENSG00000197780 E002 172.6016588 0.0014418893 2.357879e-02 5.894448e-02 1 109064140 109064462 323 - 2.174 2.300 0.419
ENSG00000197780 E003 253.1716213 0.0001982253 8.143973e-04 3.310626e-03 1 109064463 109064693 231 - 2.394 2.383 -0.036
ENSG00000197780 E004 1.4350506 0.0094164754 9.645645e-01 9.816643e-01 1 109065797 109065918 122 - 0.363 0.391 0.158
ENSG00000197780 E005 191.4719951 0.0002621643 7.348113e-11 1.325284e-09 1 109066135 109066232 98 - 2.304 2.194 -0.368
ENSG00000197780 E006 150.3425051 0.0003200944 2.883528e-06 2.165664e-05 1 109074987 109075065 79 - 2.189 2.110 -0.266
ENSG00000197780 E007 0.3686942 0.0387996416 6.191873e-01 7.366577e-01 1 109075746 109075920 175 - 0.086 0.172 1.162
ENSG00000197780 E008 112.0081039 0.0003392591 1.533719e-06 1.223404e-05 1 109075921 109076166 246 - 2.071 1.963 -0.362
ENSG00000197780 E009 3.2356990 0.0521415236 1.858382e-01 3.085609e-01 1 109078471 109078532 62 - 0.502 0.767 1.156