ENSG00000197779

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338637 ENSG00000197779 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF81 protein_coding protein_coding 4.544909 5.682629 4.101204 0.1584171 0.3141326 -0.469534 0.4883153 0.0000000 0.5183206 0.0000000 0.5183206 5.7233418 0.11193750 0.00000000 0.1121000 0.11210000 7.890344e-01 7.131209e-10 FALSE TRUE
ENST00000376950 ENSG00000197779 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF81 protein_coding protein_coding 4.544909 5.682629 4.101204 0.1584171 0.3141326 -0.469534 0.2186073 0.0000000 0.0000000 0.0000000 0.0000000 0.0000000 0.05011667 0.00000000 0.0000000 0.00000000   7.131209e-10 FALSE TRUE
MSTRG.34191.1 ENSG00000197779 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF81 protein_coding   4.544909 5.682629 4.101204 0.1584171 0.3141326 -0.469534 1.0019264 2.0117455 1.1465534 0.2709866 0.3016103 -0.8057696 0.21376250 0.35236667 0.2747000 -0.07766667 6.589097e-01 7.131209e-10   FALSE
MSTRG.34191.4 ENSG00000197779 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF81 protein_coding   4.544909 5.682629 4.101204 0.1584171 0.3141326 -0.469534 0.4595169 0.2983679 0.6879483 0.1057771 0.2747687 1.1784674 0.10704583 0.05180000 0.1801667 0.12836667 3.898083e-01 7.131209e-10 FALSE TRUE
MSTRG.34191.5 ENSG00000197779 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF81 protein_coding   4.544909 5.682629 4.101204 0.1584171 0.3141326 -0.469534 0.2891537 0.0000000 0.7409346 0.0000000 0.3919069 6.2306153 0.06635417 0.00000000 0.1911333 0.19113333 1.674921e-01 7.131209e-10 FALSE TRUE
MSTRG.34191.6 ENSG00000197779 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF81 protein_coding   4.544909 5.682629 4.101204 0.1584171 0.3141326 -0.469534 0.8679404 2.0785157 0.1635261 0.3894010 0.1635261 -3.5892534 0.18882083 0.36546667 0.0462000 -0.31926667 4.932037e-02 7.131209e-10   FALSE
MSTRG.34191.7 ENSG00000197779 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF81 protein_coding   4.544909 5.682629 4.101204 0.1584171 0.3141326 -0.469534 0.6271258 0.2471428 0.7880061 0.2471428 0.3503752 1.6338299 0.13707917 0.04556667 0.1836333 0.13806667 1.788259e-01 7.131209e-10 FALSE TRUE
MSTRG.34191.8 ENSG00000197779 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF81 protein_coding   4.544909 5.682629 4.101204 0.1584171 0.3141326 -0.469534 0.3256911 0.8191740 0.0000000 0.1635811 0.0000000 -6.3736030 0.06789167 0.14283333 0.0000000 -0.14283333 7.131209e-10 7.131209e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197779 E001 2.9087042 0.0371888265 4.221332e-04 1.859206e-03 X 47836902 47836936 35 + 0.237 0.829 2.988
ENSG00000197779 E002 2.9087042 0.0371888265 4.221332e-04 1.859206e-03 X 47836937 47836937 1 + 0.237 0.829 2.988
ENSG00000197779 E003 3.5783529 0.0072131640 1.646372e-03 6.108745e-03 X 47836938 47836939 2 + 0.389 0.855 2.087
ENSG00000197779 E004 4.2707151 0.0080234762 4.431240e-04 1.940333e-03 X 47836940 47836945 6 + 0.430 0.928 2.145
ENSG00000197779 E005 11.3760574 0.0015962483 1.195628e-05 7.802822e-05 X 47836946 47836969 24 + 0.862 1.279 1.519
ENSG00000197779 E006 16.2516000 0.0012339435 3.099215e-09 4.192649e-08 X 47836970 47836987 18 + 0.964 1.450 1.728
ENSG00000197779 E007 10.4017184 0.0017245123 7.330615e-08 7.641953e-07 X 47836988 47837007 20 + 0.747 1.288 2.006
ENSG00000197779 E008 8.2034072 0.0041194052 1.146971e-05 7.518434e-05 X 47842650 47842768 119 + 0.687 1.177 1.862
ENSG00000197779 E009 31.0784975 0.0006960003 9.405398e-18 4.641377e-16 X 47846105 47846172 68 + 1.216 1.733 1.780
ENSG00000197779 E010 43.9528461 0.0010755474 1.730000e-20 1.171563e-18 X 47846173 47846321 149 + 1.396 1.868 1.606
ENSG00000197779 E011 19.7684753 0.0024093504 4.788118e-19 2.737159e-17 X 47860720 47861045 326 + 0.890 1.602 2.528
ENSG00000197779 E012 12.6465696 0.0016184990 9.665728e-01 9.830427e-01 X 47887999 47888125 127 + 1.132 1.123 -0.032
ENSG00000197779 E013 0.2214452 0.0377812528 2.617926e-01   X 47888126 47888210 85 + 0.000 0.158 9.123
ENSG00000197779 E014 11.2950938 0.0207429795 8.894510e-01 9.333271e-01 X 47895845 47895940 96 + 1.100 1.074 -0.093
ENSG00000197779 E015 320.1076366 0.0006509204 1.223948e-106 4.293951e-103 X 47914924 47925627 10704 + 2.600 2.266 -1.114
ENSG00000197779 E016 2.8323576 0.0058104121 5.262602e-04 2.257817e-03 X 48002528 48002600 73 + 0.294 0.826 2.560