ENSG00000197771

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369077 ENSG00000197771 HEK293_OSMI2_2hA HEK293_TMG_2hB MCMBP protein_coding protein_coding 59.12885 35.18602 88.23876 3.211978 2.736396 1.326164 12.705708 7.5161861 19.083242 0.6842232 1.4106147 1.34307119 0.21028333 0.21363333 0.21616667 0.002533333 9.958510e-01 9.624124e-43 FALSE TRUE
ENST00000466047 ENSG00000197771 HEK293_OSMI2_2hA HEK293_TMG_2hB MCMBP protein_coding processed_transcript 59.12885 35.18602 88.23876 3.211978 2.736396 1.326164 2.910435 5.1387684 1.937752 1.0300283 1.2645274 -1.40241735 0.07127500 0.14370000 0.02136667 -0.122333333 2.123164e-01 9.624124e-43 FALSE TRUE
MSTRG.4734.12 ENSG00000197771 HEK293_OSMI2_2hA HEK293_TMG_2hB MCMBP protein_coding   59.12885 35.18602 88.23876 3.211978 2.736396 1.326164 3.329236 0.0000000 7.402569 0.0000000 3.5661604 9.53382981 0.03724167 0.00000000 0.08253333 0.082533333 2.516557e-05 9.624124e-43 FALSE TRUE
MSTRG.4734.4 ENSG00000197771 HEK293_OSMI2_2hA HEK293_TMG_2hB MCMBP protein_coding   59.12885 35.18602 88.23876 3.211978 2.736396 1.326164 4.573150 0.0000000 11.774176 0.0000000 0.8339730 10.20263511 0.05217500 0.00000000 0.13360000 0.133600000 9.624124e-43 9.624124e-43 FALSE TRUE
MSTRG.4734.5 ENSG00000197771 HEK293_OSMI2_2hA HEK293_TMG_2hB MCMBP protein_coding   59.12885 35.18602 88.23876 3.211978 2.736396 1.326164 3.150097 0.7187653 8.648645 0.7187653 1.5476747 3.57061508 0.05150000 0.02223333 0.09773333 0.075500000 1.130444e-01 9.624124e-43 FALSE TRUE
MSTRG.4734.6 ENSG00000197771 HEK293_OSMI2_2hA HEK293_TMG_2hB MCMBP protein_coding   59.12885 35.18602 88.23876 3.211978 2.736396 1.326164 7.859150 4.9032050 4.686083 0.4612117 4.6860828 -0.06520662 0.15020417 0.14226667 0.05356667 -0.088700000 1.149940e-01 9.624124e-43 FALSE TRUE
MSTRG.4734.7 ENSG00000197771 HEK293_OSMI2_2hA HEK293_TMG_2hB MCMBP protein_coding   59.12885 35.18602 88.23876 3.211978 2.736396 1.326164 23.847163 16.6856426 33.349481 2.1577673 0.7873481 0.99862520 0.41416250 0.47170000 0.37920000 -0.092500000 1.312786e-01 9.624124e-43 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197771 E001 1.7179325 0.1599016128 2.095442e-01 3.379951e-01 10 119829318 119829403 86 - 0.321 0.584 1.373
ENSG00000197771 E002 1.5425708 0.0094922598 2.449428e-01 3.799723e-01 10 119829404 119829439 36 - 0.322 0.532 1.128
ENSG00000197771 E003 195.4984467 0.0040016000 5.330107e-05 2.982376e-04 10 119829440 119830189 750 - 2.209 2.383 0.583
ENSG00000197771 E004 537.7722234 0.0003605501 1.817019e-37 5.328618e-35 10 119830190 119831090 901 - 2.785 2.550 -0.781
ENSG00000197771 E005 116.5792095 0.0033611726 2.951951e-04 1.360313e-03 10 119831091 119831200 110 - 2.103 1.940 -0.545
ENSG00000197771 E006 78.2018222 0.0025844371 3.061229e-06 2.285884e-05 10 119831201 119831279 79 - 1.790 2.017 0.764
ENSG00000197771 E007 54.0181870 0.0005364640 3.605300e-09 4.818776e-08 10 119831280 119831280 1 - 1.601 1.897 1.001
ENSG00000197771 E008 630.5122184 0.0012478358 2.632088e-11 5.118467e-10 10 119831281 119831600 320 - 2.723 2.879 0.519
ENSG00000197771 E009 416.8092243 0.0030835570 4.935411e-04 2.135433e-03 10 119832012 119832096 85 - 2.556 2.680 0.410
ENSG00000197771 E010 223.9491815 0.0023970367 1.504916e-05 9.603592e-05 10 119832097 119832100 4 - 2.273 2.431 0.527
ENSG00000197771 E011 582.8569766 0.0031898002 3.856749e-05 2.231604e-04 10 119835540 119835700 161 - 2.695 2.834 0.461
ENSG00000197771 E012 265.4491122 0.0041469225 2.096223e-03 7.522410e-03 10 119835701 119835704 4 - 2.359 2.490 0.437
ENSG00000197771 E013 634.2262985 0.0001235650 3.822858e-12 8.521343e-11 10 119836896 119837029 134 - 2.745 2.859 0.379
ENSG00000197771 E014 679.4993105 0.0002688535 7.997734e-07 6.780234e-06 10 119838535 119838700 166 - 2.784 2.871 0.288
ENSG00000197771 E015 511.0896301 0.0011275866 1.190874e-02 3.331524e-02 10 119840843 119840960 118 - 2.668 2.731 0.209
ENSG00000197771 E016 445.3622736 0.0010531353 2.379607e-01 3.717648e-01 10 119842472 119842595 124 - 2.620 2.656 0.121
ENSG00000197771 E017 0.4407149 0.0212165864 1.000000e+00 1.000000e+00 10 119842782 119843247 466 - 0.158 0.171 0.129
ENSG00000197771 E018 73.3307767 0.0094037931 1.099456e-01 2.054655e-01 10 119843248 119843253 6 - 1.813 1.926 0.380
ENSG00000197771 E019 565.1920025 0.0002228883 4.248938e-01 5.678369e-01 10 119843254 119843426 173 - 2.737 2.734 -0.011
ENSG00000197771 E020 469.7469271 0.0022124218 1.077973e-01 2.022829e-01 10 119847613 119847713 101 - 2.670 2.627 -0.142
ENSG00000197771 E021 572.8135097 0.0001890147 7.577962e-03 2.271410e-02 10 119849425 119849576 152 - 2.754 2.720 -0.114
ENSG00000197771 E022 549.4565810 0.0002052459 8.636487e-06 5.822414e-05 10 119853050 119853172 123 - 2.746 2.680 -0.220
ENSG00000197771 E023 299.2041184 0.0003934166 7.713676e-05 4.145154e-04 10 119853173 119853194 22 - 2.489 2.406 -0.278
ENSG00000197771 E024 255.6061088 0.0001717963 9.738367e-08 9.909784e-07 10 119857338 119857346 9 - 2.431 2.312 -0.399
ENSG00000197771 E025 473.5417959 0.0003656458 1.737670e-07 1.686025e-06 10 119857347 119857439 93 - 2.690 2.598 -0.307
ENSG00000197771 E026 2.9748667 0.1060496493 7.789854e-01 8.578280e-01 10 119857440 119858237 798 - 0.562 0.636 0.331
ENSG00000197771 E027 281.2461144 0.0003230072 1.349132e-04 6.808050e-04 10 119858884 119858925 42 - 2.462 2.381 -0.269
ENSG00000197771 E028 233.1928465 0.0001896985 3.240062e-06 2.406427e-05 10 119859041 119859049 9 - 2.390 2.282 -0.359
ENSG00000197771 E029 410.0415746 0.0033866995 3.677243e-04 1.649288e-03 10 119859050 119859181 132 - 2.635 2.519 -0.385
ENSG00000197771 E030 237.9455608 0.0050005706 5.282301e-04 2.265089e-03 10 119859799 119859884 86 - 2.407 2.260 -0.491
ENSG00000197771 E031 204.0588747 0.0091550169 2.328457e-10 3.854253e-09 10 119872527 119872967 441 - 2.390 2.033 -1.192
ENSG00000197771 E032 0.1472490 0.0435446938 1.000000e+00   10 119873431 119873621 191 - 0.086 0.000 -7.920
ENSG00000197771 E033 3.9470694 0.0051041974 1.533833e-01 2.662768e-01 10 119890785 119890978 194 - 0.750 0.532 -0.941
ENSG00000197771 E034 2.4441496 0.0062030798 5.453470e-01 6.757136e-01 10 119892239 119892312 74 - 0.561 0.466 -0.456
ENSG00000197771 E035 2.2174059 0.0088583389 6.527561e-01 7.634206e-01 10 119892470 119892556 87 - 0.534 0.466 -0.332