ENSG00000197763

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000518740 ENSG00000197763 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD3 protein_coding processed_transcript 7.958183 10.24863 7.889395 1.413759 0.2832298 -0.3770246 1.3409756 3.6882257 0.0000000 0.6012241 0.00000000 -8.53068947 0.14946667 0.35723333 0.00000000 -0.35723333 6.390169e-44 6.390169e-44   FALSE
ENST00000523403 ENSG00000197763 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD3 protein_coding protein_coding 7.958183 10.24863 7.889395 1.413759 0.2832298 -0.3770246 3.3582593 3.3195245 3.5400767 0.4444612 0.19177220 0.09253403 0.43312083 0.32546667 0.45006667 0.12460000 5.702954e-02 6.390169e-44 FALSE TRUE
ENST00000524230 ENSG00000197763 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD3 protein_coding protein_coding 7.958183 10.24863 7.889395 1.413759 0.2832298 -0.3770246 2.8678427 3.0763278 3.7975012 0.3228120 0.39965526 0.30295320 0.36510417 0.30326667 0.47906667 0.17580000 8.121155e-03 6.390169e-44 FALSE TRUE
MSTRG.23605.1 ENSG00000197763 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNRD3 protein_coding   7.958183 10.24863 7.889395 1.413759 0.2832298 -0.3770246 0.3670776 0.1301563 0.5518169 0.1301563 0.09530901 2.00306397 0.04945417 0.01013333 0.07086667 0.06073333 9.760620e-02 6.390169e-44 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197763 E001 1.632664 0.0081662973 2.125295e-02 5.411921e-02 3 126571779 126571851 73 - 0.607 0.211 -2.287
ENSG00000197763 E002 1.775647 0.0076480519 1.156613e-02 3.250366e-02 3 126571852 126572045 194 - 0.642 0.211 -2.439
ENSG00000197763 E003 2.334464 0.0520759755 7.532920e-02 1.520461e-01 3 126572156 126572642 487 - 0.675 0.352 -1.578
ENSG00000197763 E004 19.504923 0.0030121249 1.634123e-02 4.347785e-02 3 126607050 126607488 439 - 1.405 1.213 -0.671
ENSG00000197763 E005 52.597632 0.0005168453 9.670066e-09 1.196034e-07 3 126607489 126607650 162 - 1.551 1.837 0.972
ENSG00000197763 E006 135.552810 0.0002539906 2.674438e-15 9.572346e-14 3 126607651 126607973 323 - 1.991 2.229 0.796
ENSG00000197763 E007 82.356698 0.0007280621 1.903069e-07 1.831035e-06 3 126608499 126608633 135 - 1.799 2.008 0.703
ENSG00000197763 E008 0.000000       3 126609141 126609245 105 -      
ENSG00000197763 E009 59.932850 0.0036571734 5.727198e-05 3.179768e-04 3 126611037 126611132 96 - 1.657 1.873 0.730
ENSG00000197763 E010 46.443011 0.0005377383 8.181629e-01 8.850736e-01 3 126615355 126615462 108 - 1.673 1.686 0.044
ENSG00000197763 E011 87.870214 0.0003372207 2.498751e-01 3.857532e-01 3 126621742 126621898 157 - 1.926 1.969 0.145
ENSG00000197763 E012 61.819846 0.0004441774 3.462679e-01 4.904153e-01 3 126622464 126622540 77 - 1.780 1.823 0.145
ENSG00000197763 E013 65.614777 0.0005371556 4.327270e-01 5.751851e-01 3 126629379 126629471 93 - 1.808 1.843 0.117
ENSG00000197763 E014 86.957723 0.0004104435 1.756898e-01 2.955784e-01 3 126630712 126630937 226 - 1.977 1.929 -0.160
ENSG00000197763 E015 59.176024 0.0003872796 1.487976e-01 2.600461e-01 3 126631764 126631879 116 - 1.818 1.755 -0.210
ENSG00000197763 E016 74.462775 0.0004822043 1.382630e-02 3.783244e-02 3 126633909 126634051 143 - 1.931 1.834 -0.328
ENSG00000197763 E017 54.928165 0.0006228564 1.096391e-03 4.291931e-03 3 126642032 126642151 120 - 1.826 1.674 -0.514
ENSG00000197763 E018 47.262184 0.0028655917 3.182898e-02 7.552201e-02 3 126643981 126644053 73 - 1.747 1.625 -0.413
ENSG00000197763 E019 53.236909 0.0005527878 1.893203e-03 6.892965e-03 3 126644297 126644401 105 - 1.813 1.668 -0.489
ENSG00000197763 E020 58.815587 0.0005200956 7.035962e-06 4.843715e-05 3 126646111 126646220 110 - 1.880 1.680 -0.676
ENSG00000197763 E021 40.914663 0.0005871671 7.222642e-07 6.185506e-06 3 126647236 126647296 61 - 1.752 1.487 -0.904
ENSG00000197763 E022 3.260948 0.0367403335 2.605181e-03 9.079840e-03 3 126654485 126654747 263 - 0.851 0.350 -2.298
ENSG00000197763 E023 35.881576 0.0006551926 4.484889e-09 5.896653e-08 3 126654748 126655124 377 - 1.723 1.383 -1.164