ENSG00000197724

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359246 ENSG00000197724 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF2 protein_coding protein_coding 13.20857 14.66353 11.43 0.6639659 0.1940007 -0.3591283 1.525169 0.9970934 2.071866 0.2753321 0.1300350 1.04768008 0.1179292 0.06660000 0.1813000 0.11470000 8.097243e-03 5.010833e-21 FALSE TRUE
ENST00000610682 ENSG00000197724 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF2 protein_coding protein_coding 13.20857 14.66353 11.43 0.6639659 0.1940007 -0.3591283 2.011836 5.5015941 0.000000 0.8078734 0.0000000 -9.10632583 0.1369167 0.37660000 0.0000000 -0.37660000 5.010833e-21 5.010833e-21 FALSE TRUE
MSTRG.33017.3 ENSG00000197724 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF2 protein_coding   13.20857 14.66353 11.43 0.6639659 0.1940007 -0.3591283 8.327959 6.9674860 8.080657 1.2425563 0.2570291 0.21354958 0.6430458 0.47220000 0.7076000 0.23540000 5.709346e-02 5.010833e-21 FALSE TRUE
MSTRG.33017.4 ENSG00000197724 HEK293_OSMI2_2hA HEK293_TMG_2hB PHF2 protein_coding   13.20857 14.66353 11.43 0.6639659 0.1940007 -0.3591283 1.343605 1.1973535 1.277479 0.4516243 0.2648260 0.09270094 0.1021250 0.08466667 0.1111333 0.02646667 7.309249e-01 5.010833e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197724 E001 0.8836079 0.0136968632 6.921488e-03 2.101979e-02 9 93576584 93576626 43 + 0.460 0.000 -11.272
ENSG00000197724 E002 0.2924217 0.0290785164 1.894759e-01   9 93576627 93576653 27 + 0.211 0.000 -12.214
ENSG00000197724 E003 3.4720249 0.0229800461 7.225488e-03 2.180918e-02 9 93576654 93576746 93 + 0.823 0.428 -1.748
ENSG00000197724 E004 28.9848068 0.0006853188 5.488875e-05 3.061266e-04 9 93576747 93576871 125 + 1.573 1.361 -0.730
ENSG00000197724 E005 41.4189044 0.0005041814 1.209335e-03 4.672368e-03 9 93629970 93630055 86 + 1.685 1.558 -0.432
ENSG00000197724 E006 42.6452586 0.0005750594 3.233065e-03 1.095266e-02 9 93636411 93636465 55 + 1.690 1.581 -0.370
ENSG00000197724 E007 27.3759463 0.0028755320 8.962284e-02 1.745459e-01 9 93636466 93636469 4 + 1.484 1.415 -0.239
ENSG00000197724 E008 40.4631367 0.0007286166 3.919062e-02 8.953433e-02 9 93636470 93636525 56 + 1.646 1.581 -0.221
ENSG00000197724 E009 74.9390308 0.0022793267 1.997118e-06 1.553855e-05 9 93645629 93645789 161 + 1.956 1.787 -0.569
ENSG00000197724 E010 98.2564677 0.0027337202 1.553315e-05 9.878174e-05 9 93649071 93649212 142 + 2.058 1.923 -0.452
ENSG00000197724 E011 82.1935642 0.0021277369 1.526752e-04 7.588975e-04 9 93653179 93653266 88 + 1.972 1.856 -0.391
ENSG00000197724 E012 48.0427936 0.0055708300 3.706113e-02 8.558687e-02 9 93653267 93653272 6 + 1.722 1.645 -0.261
ENSG00000197724 E013 88.1310983 0.0041395764 3.296076e-03 1.113826e-02 9 93653273 93653365 93 + 1.990 1.901 -0.299
ENSG00000197724 E014 75.6769282 0.0239294760 1.709880e-02 4.516299e-02 9 93654413 93654517 105 + 1.950 1.810 -0.470
ENSG00000197724 E015 74.4625635 0.0180947127 2.860350e-02 6.921771e-02 9 93654518 93654575 58 + 1.926 1.821 -0.356
ENSG00000197724 E016 84.8655698 0.0003607802 5.622189e-04 2.392907e-03 9 93655934 93656021 88 + 1.970 1.886 -0.280
ENSG00000197724 E017 91.5898177 0.0003685037 5.223498e-04 2.243275e-03 9 93656489 93656595 107 + 2.003 1.925 -0.265
ENSG00000197724 E018 82.3375536 0.0073523157 2.073092e-01 3.352807e-01 9 93658145 93658236 92 + 1.932 1.909 -0.076
ENSG00000197724 E019 72.6114878 0.0007946526 1.691289e-01 2.870513e-01 9 93659511 93659600 90 + 1.870 1.861 -0.031
ENSG00000197724 E020 124.5303712 0.0005879742 3.811934e-04 1.702042e-03 9 93660192 93660560 369 + 2.129 2.063 -0.223
ENSG00000197724 E021 87.3904585 0.0003567500 3.531711e-06 2.603191e-05 9 93662907 93663026 120 + 2.005 1.879 -0.424
ENSG00000197724 E022 91.7236331 0.0003545358 6.335159e-03 1.949479e-02 9 93663517 93663635 119 + 1.990 1.938 -0.172
ENSG00000197724 E023 120.4873956 0.0021663014 8.502677e-01 9.071338e-01 9 93665686 93665864 179 + 2.057 2.101 0.147
ENSG00000197724 E024 81.0962935 0.0003826565 2.632503e-01 4.011290e-01 9 93665990 93666060 71 + 1.909 1.914 0.018
ENSG00000197724 E025 35.8617643 0.0006631134 8.723725e-01 9.219272e-01 9 93667077 93667079 3 + 1.535 1.593 0.198
ENSG00000197724 E026 118.0883487 0.0010214522 4.424501e-01 5.840609e-01 9 93667080 93667240 161 + 2.031 2.107 0.256
ENSG00000197724 E027 116.0432872 0.0036686539 2.183013e-01 3.483623e-01 9 93673585 93673779 195 + 2.010 2.113 0.344
ENSG00000197724 E028 49.4026801 0.0119784106 9.013389e-01 9.411100e-01 9 93673780 93673789 10 + 1.673 1.730 0.193
ENSG00000197724 E029 83.7727680 0.0036575493 2.911801e-01 4.320155e-01 9 93673790 93673862 73 + 1.872 1.971 0.334
ENSG00000197724 E030 94.5389817 0.0003504092 1.777161e-03 6.526788e-03 9 93674927 93675022 96 + 1.881 2.046 0.554
ENSG00000197724 E031 83.1417152 0.0003542352 9.841490e-02 1.880993e-01 9 93675680 93675789 110 + 1.859 1.972 0.382
ENSG00000197724 E032 142.6132962 0.0004086491 3.116248e-01 4.540911e-01 9 93676594 93676963 370 + 2.106 2.187 0.269
ENSG00000197724 E033 834.3108664 0.0054057076 3.385431e-13 8.926371e-12 9 93677588 93679587 2000 + 2.758 3.027 0.893