ENSG00000197622

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357235 ENSG00000197622 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42SE1 protein_coding protein_coding 47.75998 56.67344 43.24598 3.863395 0.4098141 -0.3900277 39.720344 51.214455 33.726914 3.2578782 0.34584528 -0.6025047 0.8259833 0.90426667 0.7799 -0.12436667 8.801937e-15 2.362011e-16   FALSE
ENST00000483763 ENSG00000197622 HEK293_OSMI2_2hA HEK293_TMG_2hB CDC42SE1 protein_coding retained_intron 47.75998 56.67344 43.24598 3.863395 0.4098141 -0.3900277 3.828571 1.514788 4.877616 0.1358828 0.06910648 1.6805225 0.0836000 0.02726667 0.1128 0.08553333 2.885750e-12 2.362011e-16 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197622 E001 7.1178399 0.0024134576 5.610784e-01 6.889755e-01 1 151050971 151050972 2 - 0.927 0.889 -0.145
ENSG00000197622 E002 8.8536536 0.0079656381 9.535358e-01 9.749127e-01 1 151050973 151050984 12 - 0.966 1.006 0.149
ENSG00000197622 E003 1658.8768104 0.0029973549 1.399165e-09 2.019408e-08 1 151050985 151052113 1129 - 3.090 3.257 0.554
ENSG00000197622 E004 1047.2775989 0.0001243452 6.723006e-01 7.783026e-01 1 151052114 151052807 694 - 2.987 3.016 0.097
ENSG00000197622 E005 364.4233869 0.0011919269 2.590546e-01 3.964176e-01 1 151052808 151052945 138 - 2.507 2.566 0.199
ENSG00000197622 E006 454.8179153 0.0006391717 6.224637e-02 1.304194e-01 1 151052946 151053119 174 - 2.596 2.666 0.234
ENSG00000197622 E007 548.3209742 0.0001776383 9.597095e-01 9.786947e-01 1 151053120 151053327 208 - 2.703 2.736 0.109
ENSG00000197622 E008 172.1633442 0.0002547381 8.335213e-01 8.957097e-01 1 151054231 151054236 6 - 2.205 2.233 0.094
ENSG00000197622 E009 376.8783569 0.0001326624 6.379884e-02 1.330204e-01 1 151054237 151054321 85 - 2.563 2.563 -0.002
ENSG00000197622 E010 485.1605486 0.0001527706 1.193013e-03 4.617312e-03 1 151055016 151055126 111 - 2.685 2.665 -0.066
ENSG00000197622 E011 25.5375455 0.0007796406 3.679507e-05 2.139306e-04 1 151055127 151055129 3 - 1.551 1.304 -0.850
ENSG00000197622 E012 21.6256261 0.0010393750 4.667859e-13 1.207746e-11 1 151055130 151055153 24 - 1.587 1.082 -1.767
ENSG00000197622 E013 66.5888526 0.0003717289 3.073469e-33 6.601582e-31 1 151055154 151055582 429 - 2.057 1.567 -1.654
ENSG00000197622 E014 23.8330777 0.0007953796 4.132250e-16 1.640835e-14 1 151055583 151055676 94 - 1.645 1.101 -1.895
ENSG00000197622 E015 747.5036039 0.0003869320 5.706060e-15 1.947039e-13 1 151055677 151055993 317 - 2.910 2.826 -0.278
ENSG00000197622 E016 7.0094911 0.0023478429 5.652115e-02 1.206345e-01 1 151056651 151056655 5 - 1.001 0.806 -0.741
ENSG00000197622 E017 20.5038329 0.0009380027 1.273963e-02 3.529932e-02 1 151056656 151056786 131 - 1.410 1.255 -0.540
ENSG00000197622 E018 283.0801798 0.0041765038 1.576037e-02 4.219433e-02 1 151059479 151059773 295 - 2.474 2.415 -0.197
ENSG00000197622 E019 2.7762461 0.0073598158 7.708984e-01 8.521125e-01 1 151067132 151067334 203 - 0.526 0.598 0.333
ENSG00000197622 E020 1.2951885 0.0102187163 5.278709e-01 6.608267e-01 1 151067335 151068318 984 - 0.410 0.318 -0.540
ENSG00000197622 E021 0.3729606 0.0317970793 7.448890e-01 8.330646e-01 1 151068319 151068380 62 - 0.144 0.104 -0.537
ENSG00000197622 E022 1.0748747 0.0850925689 6.300087e-01 7.452732e-01 1 151068381 151068495 115 - 0.338 0.260 -0.523
ENSG00000197622 E023 1.9195824 0.0267697927 7.199530e-01 8.146461e-01 1 151070264 151070325 62 - 0.410 0.498 0.453