ENSG00000197620

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393985 ENSG00000197620 HEK293_OSMI2_2hA HEK293_TMG_2hB EOLA1 protein_coding protein_coding 27.21303 44.67848 17.15151 0.6741689 0.3950118 -1.380726 2.132899 4.012035 1.478668 0.8524128 0.18044222 -1.43390341 0.07638333 0.08930000 0.08633333 -0.002966667 1.000000e+00 6.443221e-06 FALSE TRUE
ENST00000422892 ENSG00000197620 HEK293_OSMI2_2hA HEK293_TMG_2hB EOLA1 protein_coding protein_coding 27.21303 44.67848 17.15151 0.6741689 0.3950118 -1.380726 1.663205 1.219169 1.420323 0.2539679 0.04965024 0.21865666 0.06960833 0.02750000 0.08286667 0.055366667 2.694257e-04 6.443221e-06 FALSE TRUE
ENST00000423421 ENSG00000197620 HEK293_OSMI2_2hA HEK293_TMG_2hB EOLA1 protein_coding protein_coding 27.21303 44.67848 17.15151 0.6741689 0.3950118 -1.380726 13.876964 25.589479 6.517118 0.6940219 0.11480024 -1.97159644 0.48937917 0.57320000 0.38056667 -0.192633333 6.443221e-06 6.443221e-06 FALSE TRUE
ENST00000434353 ENSG00000197620 HEK293_OSMI2_2hA HEK293_TMG_2hB EOLA1 protein_coding protein_coding 27.21303 44.67848 17.15151 0.6741689 0.3950118 -1.380726 1.420740 2.589503 2.702787 0.7359784 0.09090503 0.06153952 0.06114583 0.05813333 0.15770000 0.099566667 2.245988e-02 6.443221e-06 FALSE TRUE
ENST00000450602 ENSG00000197620 HEK293_OSMI2_2hA HEK293_TMG_2hB EOLA1 protein_coding protein_coding 27.21303 44.67848 17.15151 0.6741689 0.3950118 -1.380726 2.506171 4.022267 2.032844 0.8688665 0.27392297 -0.98101232 0.09251667 0.08946667 0.11843333 0.028966667 6.281561e-01 6.443221e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197620 E001 0.3729606 0.0258539275 3.926419e-01 5.365742e-01 X 149540355 149540455 101 + 0.200 0.072 -1.697
ENSG00000197620 E002 3.4665903 0.0861193994 4.753683e-01 6.140787e-01 X 149540566 149540620 55 + 0.441 0.595 0.739
ENSG00000197620 E003 3.4697108 0.0664346705 1.949594e-01 3.199396e-01 X 149540621 149540623 3 + 0.337 0.613 1.402
ENSG00000197620 E004 4.9475461 0.0194648174 9.973609e-02 1.900723e-01 X 149540624 149540629 6 + 0.441 0.742 1.359
ENSG00000197620 E005 9.1419120 0.0019219704 7.071278e-02 1.445283e-01 X 149540630 149540641 12 + 0.708 0.960 0.985
ENSG00000197620 E006 41.0884630 0.0042803717 6.150190e-01 7.333826e-01 X 149540642 149540740 99 + 1.506 1.544 0.129
ENSG00000197620 E007 32.7916472 0.0007015514 7.929627e-01 8.676138e-01 X 149540741 149540747 7 + 1.456 1.437 -0.064
ENSG00000197620 E008 37.0914318 0.0005944549 9.146310e-01 9.499677e-01 X 149540748 149540774 27 + 1.498 1.491 -0.025
ENSG00000197620 E009 37.4999196 0.0005867708 8.776047e-01 9.253637e-01 X 149540775 149540799 25 + 1.506 1.496 -0.035
ENSG00000197620 E010 7.0865287 0.0036003444 9.958653e-02 1.898503e-01 X 149540800 149540974 175 + 0.991 0.782 -0.800
ENSG00000197620 E011 5.4215887 0.0030599672 2.075115e-01 3.355018e-01 X 149540975 149540982 8 + 0.872 0.696 -0.700
ENSG00000197620 E012 5.1228242 0.0031219011 4.852869e-01 6.231861e-01 X 149540983 149540986 4 + 0.798 0.696 -0.411
ENSG00000197620 E013 22.3085921 0.0008963335 8.828437e-02 1.724995e-01 X 149540987 149541011 25 + 1.388 1.250 -0.482
ENSG00000197620 E014 22.4139197 0.0008910080 4.620802e-01 6.019785e-01 X 149541012 149541014 3 + 1.333 1.272 -0.214
ENSG00000197620 E015 22.5119647 0.0009263362 2.819566e-01 4.219126e-01 X 149541015 149541016 2 + 1.356 1.267 -0.309
ENSG00000197620 E016 34.0301118 0.0006841678 1.396923e-01 2.475936e-01 X 149541017 149541023 7 + 1.537 1.437 -0.343
ENSG00000197620 E017 215.3590197 0.0054425934 4.161926e-01 5.595757e-01 X 149541024 149541118 95 + 2.271 2.232 -0.130
ENSG00000197620 E018 172.0597231 0.0116184465 3.440133e-01 4.880689e-01 X 149541119 149541126 8 + 2.190 2.131 -0.200
ENSG00000197620 E019 354.2542854 0.0021389848 6.419719e-01 7.549046e-01 X 149541127 149541292 166 + 2.448 2.459 0.035
ENSG00000197620 E020 186.3724355 0.0002187239 9.191746e-04 3.681576e-03 X 149541293 149541343 51 + 2.094 2.201 0.357
ENSG00000197620 E021 6.0209799 0.1378467376 1.743245e-01 2.938080e-01 X 149541344 149541436 93 + 0.991 0.698 -1.142
ENSG00000197620 E022 10.7096275 0.0522896295 8.387597e-04 3.397415e-03 X 149541437 149541768 332 + 1.321 0.844 -1.737
ENSG00000197620 E023 10.9274196 0.0053237101 1.533146e-04 7.617758e-04 X 149541769 149542018 250 + 1.269 0.865 -1.474
ENSG00000197620 E024 213.8371466 0.0002566987 3.858965e-02 8.843437e-02 X 149542019 149542066 48 + 2.193 2.254 0.205
ENSG00000197620 E025 21.8447183 0.0061511027 3.964820e-01 5.402503e-01 X 149542067 149542085 19 + 1.211 1.294 0.292
ENSG00000197620 E026 16.5170946 0.0369326289 5.666213e-04 2.408830e-03 X 149544520 149544884 365 + 1.446 1.023 -1.498
ENSG00000197620 E027 294.8099804 0.0007755623 5.952806e-01 7.173972e-01 X 149545368 149545477 110 + 2.368 2.382 0.047
ENSG00000197620 E028 163.7929759 0.0002571772 4.640851e-01 6.038471e-01 X 149545478 149545500 23 + 2.142 2.118 -0.082
ENSG00000197620 E029 2.3196115 0.0066286195 3.125170e-01 4.550551e-01 X 149545501 149545601 101 + 0.595 0.419 -0.852
ENSG00000197620 E030 352.1862089 0.0002945979 8.503162e-01 9.071446e-01 X 149545602 149545767 166 + 2.458 2.453 -0.017
ENSG00000197620 E031 332.3645447 0.0002171253 4.741576e-01 6.130122e-01 X 149545768 149545883 116 + 2.416 2.432 0.053
ENSG00000197620 E032 443.0615078 0.0015087887 1.341540e-01 2.399209e-01 X 149546739 149546917 179 + 2.525 2.563 0.128
ENSG00000197620 E033 367.3317101 0.0027752034 6.026794e-02 1.270668e-01 X 149546918 149547751 834 + 2.425 2.486 0.204
ENSG00000197620 E034 13.5676069 0.0317810707 4.232714e-01 5.663597e-01 X 149547752 149548331 580 + 0.991 1.105 0.417
ENSG00000197620 E035 0.3634088 0.3784020076 9.243129e-01   X 149549393 149549415 23 + 0.000 0.135 8.679
ENSG00000197620 E036 27.6190170 0.0010453935 4.402246e-01 5.819092e-01 X 149549416 149549671 256 + 1.409 1.349 -0.208
ENSG00000197620 E037 46.2091511 0.0022167683 1.221161e-14 3.966826e-13 X 149549672 149550615 944 + 1.888 1.451 -1.484
ENSG00000197620 E038 0.4741261 0.0221510582 1.168614e-01 2.154883e-01 X 149551679 149551850 172 + 0.337 0.072 -2.698