ENSG00000197619

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376716 ENSG00000197619 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF615 protein_coding protein_coding 2.680069 0.5142207 4.627534 0.06930456 0.3258283 3.145112 0.13875718 0.15600463 0.0000000 0.15600463 0.00000000 -4.0531516 0.11861667 0.3333333 0.00000000 -0.33333333 6.988269e-01 6.288218e-05 FALSE TRUE
ENST00000391795 ENSG00000197619 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF615 protein_coding protein_coding 2.680069 0.5142207 4.627534 0.06930456 0.3258283 3.145112 0.35109849 0.00000000 0.9007443 0.00000000 0.18313677 6.5089742 0.08080417 0.0000000 0.19563333 0.19563333 4.087296e-03 6.288218e-05 FALSE TRUE
ENST00000594083 ENSG00000197619 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF615 protein_coding protein_coding 2.680069 0.5142207 4.627534 0.06930456 0.3258283 3.145112 0.54088142 0.13858133 0.2152174 0.13858133 0.21521739 0.6000655 0.26814167 0.2130333 0.04546667 -0.16756667 7.456747e-01 6.288218e-05 FALSE TRUE
ENST00000597747 ENSG00000197619 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF615 protein_coding protein_coding 2.680069 0.5142207 4.627534 0.06930456 0.3258283 3.145112 0.36030098 0.06683427 0.2208185 0.03927262 0.11336536 1.5869369 0.11435417 0.1203667 0.04510000 -0.07526667 5.987459e-01 6.288218e-05   TRUE
ENST00000598071 ENSG00000197619 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF615 protein_coding protein_coding 2.680069 0.5142207 4.627534 0.06930456 0.3258283 3.145112 0.51263406 0.00000000 1.4047651 0.00000000 0.11948473 7.1444187 0.19155000 0.0000000 0.30773333 0.30773333 6.288218e-05 6.288218e-05 FALSE TRUE
ENST00000599115 ENSG00000197619 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF615 protein_coding nonsense_mediated_decay 2.680069 0.5142207 4.627534 0.06930456 0.3258283 3.145112 0.02128387 0.03292258 0.0000000 0.03292258 0.00000000 -2.1017366 0.02155417 0.0506000 0.00000000 -0.05060000 1.839088e-01 6.288218e-05 TRUE TRUE
ENST00000599177 ENSG00000197619 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF615 protein_coding nonsense_mediated_decay 2.680069 0.5142207 4.627534 0.06930456 0.3258283 3.145112 0.11213485 0.11987793 0.2453344 0.11987793 0.07863019 0.9752318 0.05583750 0.2826333 0.05536667 -0.22726667 1.000000e+00 6.288218e-05 FALSE TRUE
ENST00000601178 ENSG00000197619 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF615 protein_coding protein_coding 2.680069 0.5142207 4.627534 0.06930456 0.3258283 3.145112 0.43098204 0.00000000 1.5734615 0.00000000 0.41220168 7.3069380 0.08387500 0.0000000 0.33526667 0.33526667 4.133162e-04 6.288218e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197619 E001 0.0000000       19 51991332 51991333 2 -      
ENSG00000197619 E002 0.0000000       19 51991334 51991337 4 -      
ENSG00000197619 E003 0.1472490 0.0432639366 7.869489e-01   19 51991338 51991344 7 - 0.051 0.001 -6.676
ENSG00000197619 E004 28.5770055 0.0008055948 2.421053e-12 5.579142e-11 19 51991345 51992452 1108 - 1.226 1.683 1.579
ENSG00000197619 E005 22.9620232 0.0017202317 9.141271e-03 2.663590e-02 19 51992453 51992879 427 - 1.196 1.407 0.738
ENSG00000197619 E006 74.2526610 0.0044721953 1.526057e-01 2.652187e-01 19 51992880 51994614 1735 - 1.746 1.653 -0.314
ENSG00000197619 E007 6.3662515 0.0298210799 6.878683e-01 7.901089e-01 19 51994615 51994706 92 - 0.731 0.785 0.216
ENSG00000197619 E008 7.6699634 0.0023096067 5.724933e-01 6.986057e-01 19 51994707 51994807 101 - 0.823 0.718 -0.420
ENSG00000197619 E009 4.4246096 0.0038275511 8.367168e-03 2.470635e-02 19 51994808 51994837 30 - 0.678 0.000 -12.078
ENSG00000197619 E010 1.0975895 0.0134762636 5.384567e-03 1.697265e-02 19 52000125 52000258 134 - 0.139 0.641 3.162
ENSG00000197619 E011 1.6951184 0.0091320969 4.494947e-02 1.001063e-01 19 52000259 52000345 87 - 0.274 0.641 1.940
ENSG00000197619 E012 2.2121971 0.0065655555 4.587381e-01 5.990293e-01 19 52000346 52000357 12 - 0.440 0.266 -1.059
ENSG00000197619 E013 2.8367944 0.0056850631 2.868956e-01 4.273489e-01 19 52000358 52000378 21 - 0.513 0.266 -1.421
ENSG00000197619 E014 10.4032039 0.0018855427 5.340475e-02 1.152136e-01 19 52001813 52001908 96 - 0.968 0.641 -1.296
ENSG00000197619 E015 11.7403259 0.0015622499 6.390091e-02 1.331936e-01 19 52002155 52002272 118 - 1.012 0.717 -1.139
ENSG00000197619 E016 6.5784150 0.0030189238 6.810340e-02 1.402222e-01 19 52002273 52002281 9 - 0.797 0.429 -1.643
ENSG00000197619 E017 9.9522466 0.0283567845 1.504763e-03 5.651712e-03 19 52003697 52003781 85 - 0.968 0.266 -3.295
ENSG00000197619 E018 8.1735033 0.0021469323 1.985998e-02 5.119486e-02 19 52003782 52003848 67 - 0.884 0.429 -1.979
ENSG00000197619 E019 6.9699127 0.0025661675 4.908921e-02 1.075344e-01 19 52003849 52003900 52 - 0.823 0.429 -1.743
ENSG00000197619 E020 0.1515154 0.0434475767 7.879427e-01   19 52004417 52004723 307 - 0.051 0.000 -8.299
ENSG00000197619 E021 0.0000000       19 52004724 52004849 126 -      
ENSG00000197619 E022 2.6624769 0.0059203687 3.227060e-01 4.660466e-01 19 52007293 52007330 38 - 0.496 0.266 -1.339
ENSG00000197619 E023 0.1451727 0.0430888839 7.855620e-01   19 52007959 52008081 123 - 0.051 0.000 -8.299
ENSG00000197619 E024 7.0192436 0.0023544049 1.606113e-01 2.759372e-01 19 52008141 52008230 90 - 0.814 0.548 -1.126