ENSG00000197601

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354817 ENSG00000197601 HEK293_OSMI2_2hA HEK293_TMG_2hB FAR1 protein_coding protein_coding 26.5024 5.026188 52.04207 0.6555732 0.9260848 3.369552 16.313734 4.780559 32.17090 0.6220685 1.055208 2.747938 0.7388625 0.9512667 0.6178667 -0.3334000 2.087909e-22 7.73902e-25 FALSE TRUE
ENST00000532701 ENSG00000197601 HEK293_OSMI2_2hA HEK293_TMG_2hB FAR1 protein_coding protein_coding 26.5024 5.026188 52.04207 0.6555732 0.9260848 3.369552 7.005605 0.000000 14.32238 0.0000000 1.056984 10.485062 0.1459625 0.0000000 0.2749333 0.2749333 7.739020e-25 7.73902e-25 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197601 E001 1.4769841 0.0089719950 2.943542e-01 4.354624e-01 11 13668629 13668667 39 + 0.266 0.000 -13.575
ENSG00000197601 E002 14.8969773 0.0162434910 2.458347e-02 6.101807e-02 11 13668668 13668710 43 + 0.961 0.778 -0.701
ENSG00000197601 E003 72.0380357 0.0492712378 5.114070e-02 1.112005e-01 11 13668711 13668806 96 + 1.593 1.568 -0.084
ENSG00000197601 E004 1.1909051 0.0105059941 4.175074e-01 5.608499e-01 11 13669023 13669121 99 + 0.225 0.000 -13.249
ENSG00000197601 E005 2.5354020 0.0318939457 1.115743e-01 2.078655e-01 11 13671113 13671200 88 + 0.388 0.000 -14.338
ENSG00000197601 E006 0.2987644 0.0273140368 1.000000e+00   11 13694756 13694758 3 + 0.068 0.000 -11.249
ENSG00000197601 E007 152.0780686 0.0532043515 1.698051e-02 4.489051e-02 11 13694759 13694899 141 + 1.914 1.860 -0.180
ENSG00000197601 E008 130.7167282 0.0020092782 3.358466e-07 3.075461e-06 11 13694900 13694954 55 + 1.850 1.777 -0.248
ENSG00000197601 E009 184.8095822 0.0009814880 7.672642e-06 5.233147e-05 11 13700317 13700492 176 + 1.991 2.021 0.101
ENSG00000197601 E010 0.1515154 0.0431812311 6.672567e-01   11 13700493 13700567 75 + 0.035 0.000 -10.250
ENSG00000197601 E011 227.3779585 0.0002909876 3.742706e-12 8.357432e-11 11 13707900 13708079 180 + 2.087 2.031 -0.189
ENSG00000197601 E012 145.5206097 0.0002706413 2.781657e-11 5.389411e-10 11 13710693 13710723 31 + 1.900 1.767 -0.447
ENSG00000197601 E013 250.8196710 0.0002091261 2.655483e-14 8.202450e-13 11 13710724 13710870 147 + 2.130 2.060 -0.236
ENSG00000197601 E014 4.6637227 0.1773841900 6.027989e-01 7.237048e-01 11 13710871 13711099 229 + 0.539 0.545 0.030
ENSG00000197601 E015 135.4227943 0.0002595318 2.487032e-08 2.845861e-07 11 13711764 13711808 45 + 1.865 1.794 -0.239
ENSG00000197601 E016 104.3061981 0.0220849627 7.523570e-03 2.257463e-02 11 13711928 13711931 4 + 1.751 1.721 -0.100
ENSG00000197601 E017 220.9456267 0.0001964790 7.039495e-12 1.503677e-10 11 13711932 13712046 115 + 2.075 2.020 -0.183
ENSG00000197601 E018 5.1787370 0.0081749469 8.423590e-02 1.661957e-01 11 13712047 13712055 9 + 0.589 0.352 -1.204
ENSG00000197601 E019 161.0514935 0.0022917137 1.159398e-08 1.413232e-07 11 13712966 13713033 68 + 1.942 1.859 -0.279
ENSG00000197601 E020 1.9679483 0.0887238477 7.723448e-01 8.530404e-01 11 13713034 13713084 51 + 0.305 0.353 0.298
ENSG00000197601 E021 234.8873584 0.0026835280 2.125380e-05 1.309719e-04 11 13714509 13714680 172 + 2.094 2.138 0.147
ENSG00000197601 E022 2.6655854 0.0746657710 1.124106e-01 2.090533e-01 11 13715801 13715843 43 + 0.402 0.000 -14.419
ENSG00000197601 E023 38.5278702 0.0005746534 7.900009e-02 1.579127e-01 11 13719903 13721729 1827 + 1.324 1.394 0.243
ENSG00000197601 E024 203.5919414 0.0003417804 7.514043e-03 2.254963e-02 11 13721730 13721859 130 + 2.023 2.157 0.450
ENSG00000197601 E025 208.5364703 0.0009019233 1.370694e-05 8.819847e-05 11 13727556 13727683 128 + 2.041 2.092 0.170
ENSG00000197601 E026 1757.2784969 0.0259091795 6.858213e-09 8.718749e-08 11 13728612 13732346 3735 + 2.906 3.390 1.608