ENSG00000197594

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000513998 ENSG00000197594 HEK293_OSMI2_2hA HEK293_TMG_2hB ENPP1 protein_coding nonsense_mediated_decay 5.012124 3.014689 6.15273 0.255052 0.1539729 1.026783 0.1087221 0.2069454 0.02912681 0.2069454 0.02912681 -2.471102 0.0224750 0.07483333 0.004533333 -0.0703000 8.761791e-01 2.66773e-17 FALSE TRUE
ENST00000647893 ENSG00000197594 HEK293_OSMI2_2hA HEK293_TMG_2hB ENPP1 protein_coding protein_coding 5.012124 3.014689 6.15273 0.255052 0.1539729 1.026783 2.3202488 0.4495280 5.66740209 0.2277993 0.13406905 3.627006 0.4119083 0.14366667 0.921300000 0.7776333 1.514606e-04 2.66773e-17 FALSE TRUE
ENST00000684674 ENSG00000197594 HEK293_OSMI2_2hA HEK293_TMG_2hB ENPP1 protein_coding retained_intron 5.012124 3.014689 6.15273 0.255052 0.1539729 1.026783 0.4474784 1.0880796 0.04976178 0.2442180 0.03883161 -4.199616 0.1455000 0.35476667 0.008100000 -0.3466667 8.478157e-08 2.66773e-17 FALSE TRUE
MSTRG.28963.5 ENSG00000197594 HEK293_OSMI2_2hA HEK293_TMG_2hB ENPP1 protein_coding   5.012124 3.014689 6.15273 0.255052 0.1539729 1.026783 1.9297535 1.2095176 0.00000000 0.1478262 0.00000000 -6.930167 0.3803958 0.40676667 0.000000000 -0.4067667 2.667730e-17 2.66773e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197594 E001 0.2966881 0.0290785164 5.733603e-01   6 131808016 131808019 4 + 0.136 0.000 -9.818
ENSG00000197594 E002 2.2070002 0.0069197032 2.452972e-03 8.623113e-03 6 131808020 131808033 14 + 0.575 0.000 -14.910
ENSG00000197594 E003 6.3601894 0.0027556193 3.658250e-04 1.641974e-03 6 131808034 131808122 89 + 0.913 0.436 -2.057
ENSG00000197594 E004 17.1419014 0.0010825636 1.776786e-05 1.114740e-04 6 131808123 131808275 153 + 1.284 0.957 -1.179
ENSG00000197594 E005 0.0000000       6 131826022 131826079 58 +      
ENSG00000197594 E006 0.0000000       6 131826080 131826115 36 +      
ENSG00000197594 E007 0.0000000       6 131844463 131844980 518 +      
ENSG00000197594 E008 12.6743156 0.0014087473 1.765998e-02 4.640391e-02 6 131847776 131847794 19 + 1.131 0.983 -0.537
ENSG00000197594 E009 20.7675024 0.0012824245 3.699700e-04 1.657986e-03 6 131847795 131847848 54 + 1.342 1.135 -0.730
ENSG00000197594 E010 15.1292779 0.0012065708 9.423053e-04 3.762211e-03 6 131849990 131849998 9 + 1.217 0.984 -0.842
ENSG00000197594 E011 29.8287757 0.0006928383 1.617012e-06 1.283468e-05 6 131849999 131850106 108 + 1.502 1.247 -0.882
ENSG00000197594 E012 35.2035579 0.0007031433 8.449624e-08 8.700706e-07 6 131851142 131851267 126 + 1.571 1.301 -0.934
ENSG00000197594 E013 0.4407149 0.0213079121 8.898589e-01 9.336082e-01 6 131851268 131851423 156 + 0.136 0.197 0.642
ENSG00000197594 E014 27.4546510 0.0052876813 9.328266e-05 4.904457e-04 6 131852175 131852235 61 + 1.459 1.234 -0.785
ENSG00000197594 E015 31.6090124 0.0162635334 1.747037e-04 8.557306e-04 6 131854926 131855023 98 + 1.524 1.264 -0.901
ENSG00000197594 E016 29.2391599 0.0182392016 4.862620e-05 2.748072e-04 6 131858668 131858747 80 + 1.504 1.187 -1.104
ENSG00000197594 E017 34.2378516 0.0006130063 5.117085e-07 4.517529e-06 6 131860387 131860506 120 + 1.558 1.313 -0.847
ENSG00000197594 E018 19.1520783 0.0010829492 7.793156e-03 2.325702e-02 6 131861595 131861609 15 + 1.296 1.170 -0.445
ENSG00000197594 E019 32.1601680 0.0023144959 2.078121e-04 9.973246e-04 6 131861610 131861704 95 + 1.519 1.358 -0.553
ENSG00000197594 E020 24.6957156 0.0013885473 1.576473e-02 4.220422e-02 6 131864506 131864571 66 + 1.390 1.313 -0.270
ENSG00000197594 E021 0.1482932 0.0408438333 2.012664e-01   6 131864572 131864865 294 + 0.000 0.197 12.077
ENSG00000197594 E022 18.3727182 0.0010345694 8.741589e-03 2.563930e-02 6 131864866 131864891 26 + 1.280 1.153 -0.448
ENSG00000197594 E023 17.7878853 0.0010320079 8.777536e-02 1.717544e-01 6 131864892 131864938 47 + 1.245 1.203 -0.148
ENSG00000197594 E024 1.6616952 0.0987870652 4.628921e-01 6.027468e-01 6 131864939 131866009 1071 + 0.424 0.332 -0.533
ENSG00000197594 E025 15.3170089 0.0013740447 8.840154e-03 2.588231e-02 6 131868018 131868036 19 + 1.207 1.055 -0.545
ENSG00000197594 E026 20.7805006 0.0071415093 9.693572e-03 2.800613e-02 6 131868037 131868126 90 + 1.331 1.201 -0.456
ENSG00000197594 E027 26.5064584 0.0007088353 6.657937e-03 2.033543e-02 6 131869358 131869489 132 + 1.419 1.325 -0.325
ENSG00000197594 E028 21.1768661 0.0045816591 3.171023e-03 1.076982e-02 6 131872070 131872101 32 + 1.335 1.171 -0.576
ENSG00000197594 E029 35.1179505 0.0136046410 4.379817e-02 9.802190e-02 6 131872923 131873050 128 + 1.527 1.459 -0.231
ENSG00000197594 E030 0.0000000       6 131874205 131874267 63 +      
ENSG00000197594 E031 27.1397729 0.0020621488 1.748057e-01 2.944519e-01 6 131874268 131874337 70 + 1.400 1.411 0.036
ENSG00000197594 E032 0.1472490 0.0430427705 1.000000e+00   6 131875269 131875775 507 + 0.073 0.000 -10.959
ENSG00000197594 E033 31.7867081 0.0006800894 9.416629e-02 1.816448e-01 6 131875776 131875863 88 + 1.473 1.473 0.001
ENSG00000197594 E034 46.0929097 0.0004762839 3.251271e-01 4.685514e-01 6 131876992 131877161 170 + 1.612 1.672 0.203
ENSG00000197594 E035 1.3349293 0.0105461123 2.310610e-01 3.637390e-01 6 131877162 131877867 706 + 0.240 0.519 1.644
ENSG00000197594 E036 0.2987644 0.0293784633 5.723836e-01   6 131878119 131878163 45 + 0.136 0.000 -12.054
ENSG00000197594 E037 21.8970701 0.0009060602 9.998329e-01 1.000000e+00 6 131878542 131878593 52 + 1.280 1.391 0.386
ENSG00000197594 E038 0.9747559 0.3006702625 6.408702e-01 7.540288e-01 6 131879504 131879879 376 + 0.285 0.201 -0.658
ENSG00000197594 E039 37.4139425 0.0006637690 9.104826e-02 1.767859e-01 6 131879880 131880034 155 + 1.536 1.543 0.026
ENSG00000197594 E040 0.1451727 0.0430400572 1.000000e+00   6 131880137 131880287 151 + 0.073 0.000 -10.959
ENSG00000197594 E041 37.1218140 0.0012935749 1.037002e-02 2.967313e-02 6 131882345 131882474 130 + 1.552 1.498 -0.184
ENSG00000197594 E042 31.2296241 0.0054762586 6.795101e-02 1.399647e-01 6 131883694 131883774 81 + 1.470 1.439 -0.107
ENSG00000197594 E043 45.8312993 0.0053001634 4.368358e-01 5.788635e-01 6 131884931 131885063 133 + 1.604 1.663 0.200
ENSG00000197594 E044 55.2501300 0.0005559721 5.007544e-01 6.369823e-01 6 131886562 131886724 163 + 1.657 1.804 0.499
ENSG00000197594 E045 524.0574043 0.0049177885 1.189035e-30 2.097384e-28 6 131890341 131895155 4815 + 2.529 2.914 1.283