ENSG00000197568

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359875 ENSG00000197568 HEK293_OSMI2_2hA HEK293_TMG_2hB HHLA3 lncRNA lncRNA 43.19354 77.38947 26.75204 2.173488 0.7488729 -1.532136 3.839791 6.457185 1.852248 0.5044673 0.34966526 -1.7960924 0.09333333 0.08323333 0.0687000 -0.014533333 6.375181e-01 8.255482e-06 FALSE  
ENST00000361764 ENSG00000197568 HEK293_OSMI2_2hA HEK293_TMG_2hB HHLA3 lncRNA lncRNA 43.19354 77.38947 26.75204 2.173488 0.7488729 -1.532136 17.203745 31.933925 10.438421 2.1098607 0.59937040 -1.6122567 0.38826250 0.41246667 0.3911667 -0.021300000 8.613548e-01 8.255482e-06 FALSE  
ENST00000370940 ENSG00000197568 HEK293_OSMI2_2hA HEK293_TMG_2hB HHLA3 lncRNA lncRNA 43.19354 77.38947 26.75204 2.173488 0.7488729 -1.532136 11.037001 20.567701 5.424945 1.8119798 0.94587099 -1.9207444 0.24394167 0.26553333 0.2016333 -0.063900000 4.211874e-01 8.255482e-06 FALSE  
ENST00000463058 ENSG00000197568 HEK293_OSMI2_2hA HEK293_TMG_2hB HHLA3 lncRNA lncRNA 43.19354 77.38947 26.75204 2.173488 0.7488729 -1.532136 4.388946 8.471815 3.175701 0.7224664 0.09702602 -1.4127623 0.10360000 0.11010000 0.1190667 0.008966667 8.433765e-01 8.255482e-06 TRUE  
ENST00000689607 ENSG00000197568 HEK293_OSMI2_2hA HEK293_TMG_2hB HHLA3 lncRNA lncRNA 43.19354 77.38947 26.75204 2.173488 0.7488729 -1.532136 4.546790 6.778058 4.065211 0.2886106 0.08646606 -0.7361243 0.11264583 0.08756667 0.1522667 0.064700000 8.255482e-06 8.255482e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197568 E001 1.6491210 0.0513930782 0.103205212 0.19535703 1 70354786 70354792 7 + 0.586 0.285 -1.619
ENSG00000197568 E002 2.1693306 0.0084264340 0.022895100 0.05752378 1 70354793 70354797 5 + 0.699 0.325 -1.844
ENSG00000197568 E003 6.1455491 0.0152446122 0.066965086 0.13832948 1 70354798 70354811 14 + 0.954 0.707 -0.966
ENSG00000197568 E004 93.8499467 0.0028724869 0.257892456 0.39506863 1 70354812 70354843 32 + 1.920 1.878 -0.144
ENSG00000197568 E005 116.8581865 0.0086019686 0.614276350 0.73279397 1 70354844 70354854 11 + 1.994 1.978 -0.055
ENSG00000197568 E006 515.0686284 0.0008988098 0.079217840 0.15826108 1 70354855 70355107 253 + 2.640 2.619 -0.069
ENSG00000197568 E007 92.1031624 0.0004139910 0.441613831 0.58325722 1 70355108 70355111 4 + 1.896 1.876 -0.067
ENSG00000197568 E008 41.2733944 0.0005504862 0.752081540 0.83837850 1 70355112 70355208 97 + 1.547 1.541 -0.023
ENSG00000197568 E009 26.1599036 0.0007576194 0.005809193 0.01811132 1 70366146 70366328 183 + 1.495 1.307 -0.652
ENSG00000197568 E010 395.5141570 0.0006110933 0.112660826 0.20943651 1 70366444 70366537 94 + 2.474 2.522 0.160
ENSG00000197568 E011 75.9537966 0.0003908840 0.027308879 0.06662183 1 70366933 70366984 52 + 1.867 1.779 -0.295
ENSG00000197568 E012 599.7545909 0.0037252633 0.021440565 0.05451490 1 70367617 70368023 407 + 2.632 2.707 0.249
ENSG00000197568 E013 0.1817044 0.0392689727 1.000000000   1 70385258 70385339 82 + 0.001 0.074 6.985