ENSG00000197555

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381232 ENSG00000197555 HEK293_OSMI2_2hA HEK293_TMG_2hB SIPA1L1 protein_coding protein_coding 6.737569 7.608031 6.901536 0.3754851 0.2288342 -0.1404118 1.5091996 1.6718640 1.47217034 0.09579392 0.76360038 -0.1823498 0.22594167 0.22173333 0.21803333 -0.00370000 0.89948801 0.00241476 FALSE TRUE
ENST00000537413 ENSG00000197555 HEK293_OSMI2_2hA HEK293_TMG_2hB SIPA1L1 protein_coding protein_coding 6.737569 7.608031 6.901536 0.3754851 0.2288342 -0.1404118 0.7760867 2.2596012 0.07927845 0.41355554 0.07927845 -4.6679831 0.10972917 0.29603333 0.01226667 -0.28376667 0.00241476 0.00241476 FALSE TRUE
ENST00000554874 ENSG00000197555 HEK293_OSMI2_2hA HEK293_TMG_2hB SIPA1L1 protein_coding processed_transcript 6.737569 7.608031 6.901536 0.3754851 0.2288342 -0.1404118 0.1599039 0.7364284 0.01083849 0.36843164 0.01083849 -5.1626810 0.02219167 0.09640000 0.00150000 -0.09490000 0.19036265 0.00241476 FALSE TRUE
MSTRG.9838.11 ENSG00000197555 HEK293_OSMI2_2hA HEK293_TMG_2hB SIPA1L1 protein_coding   6.737569 7.608031 6.901536 0.3754851 0.2288342 -0.1404118 0.5167529 0.2420158 0.62428847 0.13920534 0.32766323 1.3316248 0.07792083 0.03026667 0.09193333 0.06166667 0.82460913 0.00241476 FALSE TRUE
MSTRG.9838.20 ENSG00000197555 HEK293_OSMI2_2hA HEK293_TMG_2hB SIPA1L1 protein_coding   6.737569 7.608031 6.901536 0.3754851 0.2288342 -0.1404118 0.2424143 0.0000000 0.40828906 0.00000000 0.21605977 5.3864284 0.04015833 0.00000000 0.05926667 0.05926667 0.17751164 0.00241476 FALSE TRUE
MSTRG.9838.3 ENSG00000197555 HEK293_OSMI2_2hA HEK293_TMG_2hB SIPA1L1 protein_coding   6.737569 7.608031 6.901536 0.3754851 0.2288342 -0.1404118 0.4905956 0.4538615 1.28398569 0.23931471 0.67320532 1.4800556 0.07365833 0.06236667 0.17983333 0.11746667 0.84263907 0.00241476 FALSE TRUE
MSTRG.9838.5 ENSG00000197555 HEK293_OSMI2_2hA HEK293_TMG_2hB SIPA1L1 protein_coding   6.737569 7.608031 6.901536 0.3754851 0.2288342 -0.1404118 0.7661933 0.5087689 0.65664068 0.41211527 0.39614826 0.3618173 0.11106667 0.06760000 0.09583333 0.02823333 0.89748285 0.00241476 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197555 E001 0.2214452 0.0401929587 6.036335e-01   14 71320420 71320424 5 + 0.000 0.108 9.564
ENSG00000197555 E002 0.3729606 0.0309657924 8.591274e-01 9.130997e-01 14 71320425 71320425 1 + 0.139 0.108 -0.413
ENSG00000197555 E003 0.5944058 0.3648538552 7.801403e-01 8.586857e-01 14 71320426 71320435 10 + 0.139 0.201 0.643
ENSG00000197555 E004 1.6146892 0.0162060919 1.836044e-01 3.057308e-01 14 71320436 71320448 13 + 0.243 0.474 1.394
ENSG00000197555 E005 1.9446868 0.0110016469 7.640544e-02 1.537515e-01 14 71320449 71320459 11 + 0.243 0.549 1.755
ENSG00000197555 E006 2.5682520 0.0642870088 4.728657e-01 6.119057e-01 14 71320460 71320472 13 + 0.459 0.583 0.592
ENSG00000197555 E007 2.7499564 0.1026256838 4.222634e-01 5.654144e-01 14 71320473 71320475 3 + 0.459 0.615 0.734
ENSG00000197555 E008 6.1998180 0.0903595349 2.654665e-01 4.035227e-01 14 71320476 71320503 28 + 0.966 0.746 -0.852
ENSG00000197555 E009 1.3920876 0.0233694312 4.918631e-01 6.291107e-01 14 71320504 71320514 11 + 0.459 0.327 -0.741
ENSG00000197555 E010 2.1316792 0.0077253366 4.757297e-01 6.144199e-01 14 71320515 71320552 38 + 0.560 0.430 -0.638
ENSG00000197555 E011 11.5862165 0.0231335138 4.659541e-03 1.498423e-02 14 71321122 71321181 60 + 1.271 0.921 -1.268
ENSG00000197555 E012 0.0000000       14 71321391 71321531 141 +      
ENSG00000197555 E013 0.0000000       14 71379495 71379598 104 +      
ENSG00000197555 E014 1.6480794 0.0290331281 1.585857e-03 5.912929e-03 14 71400794 71400918 125 + 0.677 0.108 -3.736
ENSG00000197555 E015 4.3128681 0.0549640806 2.629552e-02 6.454197e-02 14 71413948 71413953 6 + 0.911 0.514 -1.654
ENSG00000197555 E016 3.9764391 0.0439216976 3.968890e-02 9.044801e-02 14 71413954 71413960 7 + 0.869 0.513 -1.499
ENSG00000197555 E017 6.6283294 0.0215910866 9.172731e-03 2.671565e-02 14 71413961 71414014 54 + 1.062 0.694 -1.416
ENSG00000197555 E018 0.1515154 0.0428243380 3.892515e-01   14 71414015 71414102 88 + 0.139 0.000 -13.388
ENSG00000197555 E019 0.0000000       14 71415976 71416283 308 +      
ENSG00000197555 E020 2.0899507 0.0503160001 9.536197e-02 1.834358e-01 14 71418130 71418196 67 + 0.642 0.329 -1.577
ENSG00000197555 E021 0.1451727 0.0433921594 3.892358e-01   14 71467185 71467247 63 + 0.139 0.000 -13.385
ENSG00000197555 E022 0.0000000       14 71497854 71497889 36 +      
ENSG00000197555 E023 0.2987644 0.0270209096 1.421368e-01   14 71503828 71503946 119 + 0.244 0.000 -14.454
ENSG00000197555 E024 24.5507939 0.0077153831 9.087752e-07 7.613530e-06 14 71512743 71512845 103 + 1.599 1.188 -1.426
ENSG00000197555 E025 2.6021201 0.0706226846 9.867698e-02 1.884729e-01 14 71528699 71528740 42 + 0.711 0.384 -1.547
ENSG00000197555 E026 15.9993677 0.0017416775 7.560217e-05 4.071345e-04 14 71529312 71529324 13 + 1.399 1.047 -1.246
ENSG00000197555 E027 23.2376865 0.0072373607 2.838150e-07 2.639952e-06 14 71529325 71529370 46 + 1.587 1.154 -1.504
ENSG00000197555 E028 20.0778449 0.0249391105 1.120739e-01 2.085836e-01 14 71573489 71575086 1598 + 1.418 1.241 -0.618
ENSG00000197555 E029 2.9861528 0.0057653192 6.050969e-01 7.255119e-01 14 71576535 71576587 53 + 0.642 0.549 -0.416
ENSG00000197555 E030 0.2998086 0.0292256459 8.548452e-01   14 71586281 71586928 648 + 0.139 0.108 -0.419
ENSG00000197555 E031 240.3489477 0.0250309623 3.272167e-05 1.929056e-04 14 71587571 71589370 1800 + 2.534 2.225 -1.028
ENSG00000197555 E032 0.1472490 0.0431346501 3.893866e-01   14 71598234 71598331 98 + 0.139 0.000 -13.386
ENSG00000197555 E033 0.0000000       14 71618756 71618756 1 +      
ENSG00000197555 E034 50.4006374 0.0081528664 1.037764e-02 2.969000e-02 14 71618757 71618887 131 + 1.802 1.622 -0.611
ENSG00000197555 E035 62.1933191 0.0011362283 1.672973e-03 6.196399e-03 14 71624048 71624236 189 + 1.882 1.721 -0.545
ENSG00000197555 E036 0.2934659 0.0290502303 8.547111e-01   14 71650290 71650334 45 + 0.139 0.108 -0.418
ENSG00000197555 E037 57.0809552 0.0047427342 4.356859e-02 9.758851e-02 14 71650335 71650509 175 + 1.825 1.696 -0.437
ENSG00000197555 E038 44.3883268 0.0007873759 1.202379e-03 4.648811e-03 14 71658333 71658436 104 + 1.747 1.559 -0.639
ENSG00000197555 E039 55.4233513 0.0016998070 4.343217e-02 9.735200e-02 14 71661310 71661467 158 + 1.807 1.689 -0.399
ENSG00000197555 E040 139.4911658 0.0007214360 2.779261e-02 6.760605e-02 14 71671119 71671692 574 + 2.186 2.101 -0.287
ENSG00000197555 E041 85.4051760 0.0027373824 3.596818e-01 5.039988e-01 14 71672348 71672622 275 + 1.962 1.906 -0.189
ENSG00000197555 E042 86.4218030 0.0008264566 7.782358e-01 8.573010e-01 14 71685362 71685631 270 + 1.932 1.926 -0.020
ENSG00000197555 E043 67.5770190 0.0006490552 4.044296e-01 5.481325e-01 14 71698981 71699127 147 + 1.853 1.799 -0.181
ENSG00000197555 E044 0.1515154 0.0428243380 3.892515e-01   14 71702312 71702380 69 + 0.139 0.000 -13.388
ENSG00000197555 E045 62.9397149 0.0008001955 1.851926e-01 3.077273e-01 14 71702381 71702505 125 + 1.770 1.814 0.149
ENSG00000197555 E046 1.5007391 0.0093710424 5.267496e-01 6.599332e-01 14 71704721 71704783 63 + 0.328 0.430 0.584
ENSG00000197555 E047 3.1916798 0.0114926871 1.619732e-01 2.776928e-01 14 71704784 71705221 438 + 0.741 0.512 -1.000
ENSG00000197555 E048 56.7972843 0.0004685017 2.976046e-01 4.389588e-01 14 71705222 71705340 119 + 1.732 1.765 0.109
ENSG00000197555 E049 129.1915027 0.0002675098 8.064276e-01 8.769656e-01 14 71709222 71709664 443 + 2.110 2.101 -0.031
ENSG00000197555 E050 100.0834898 0.0006457377 6.737625e-02 1.389924e-01 14 71723647 71723886 240 + 1.960 2.010 0.169
ENSG00000197555 E051 93.3446983 0.0023435969 1.655191e-03 6.138229e-03 14 71724670 71724835 166 + 1.884 2.003 0.401
ENSG00000197555 E052 90.8495441 0.0073728677 5.363498e-03 1.691834e-02 14 71730055 71730191 137 + 1.858 1.997 0.467
ENSG00000197555 E053 87.7328582 0.0030068921 5.093730e-07 4.499565e-06 14 71730192 71730301 110 + 1.786 2.006 0.739
ENSG00000197555 E054 89.6427567 0.0105325771 5.591936e-05 3.112515e-04 14 71733666 71733812 147 + 1.781 2.019 0.802
ENSG00000197555 E055 77.4354499 0.0162750429 9.481417e-04 3.781465e-03 14 71735277 71735391 115 + 1.724 1.956 0.785
ENSG00000197555 E056 0.7446882 0.5400021704 6.115603e-01 7.306579e-01 14 71735392 71735593 202 + 0.139 0.311 1.473
ENSG00000197555 E057 24.1769570 0.0099100934 1.723930e-02 4.547514e-02 14 71738241 71738243 3 + 1.263 1.452 0.658
ENSG00000197555 E058 74.9411484 0.0064563851 6.263286e-08 6.618478e-07 14 71738244 71738325 82 + 1.660 1.960 1.010
ENSG00000197555 E059 208.2332170 0.0022485976 4.690604e-14 1.397862e-12 14 71739018 71741229 2212 + 2.152 2.385 0.776