ENSG00000197535

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000399229 ENSG00000197535 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO5A protein_coding protein_coding 3.92726 1.84517 5.565679 0.1470747 0.1431644 1.587596 0.51257886 0.27833622 0.70081761 0.16129803 0.06900611 1.301727 0.12444583 0.14516667 0.12630000 -0.018866667 9.510632e-01 2.592787e-08 FALSE TRUE
ENST00000399231 ENSG00000197535 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO5A protein_coding protein_coding 3.92726 1.84517 5.565679 0.1470747 0.1431644 1.587596 0.13249021 0.04894108 0.29803012 0.04894108 0.29803012 2.385726 0.05111667 0.02313333 0.05436667 0.031233333 9.068410e-01 2.592787e-08 FALSE TRUE
ENST00000553916 ENSG00000197535 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO5A protein_coding protein_coding 3.92726 1.84517 5.565679 0.1470747 0.1431644 1.587596 0.07249711 0.00000000 0.32009958 0.00000000 0.05197970 5.044829 0.01318333 0.00000000 0.05806667 0.058066667 4.739039e-03 2.592787e-08 FALSE TRUE
ENST00000686171 ENSG00000197535 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO5A protein_coding nonsense_mediated_decay 3.92726 1.84517 5.565679 0.1470747 0.1431644 1.587596 0.03792042 0.25050426 0.00000000 0.12826482 0.00000000 -4.703235 0.01732917 0.12973333 0.00000000 -0.129733333 2.835284e-02 2.592787e-08 FALSE TRUE
ENST00000686603 ENSG00000197535 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO5A protein_coding retained_intron 3.92726 1.84517 5.565679 0.1470747 0.1431644 1.587596 0.28952156 0.46692327 0.06553969 0.05516310 0.03880662 -2.658450 0.12142917 0.25623333 0.01173333 -0.244500000 2.592787e-08 2.592787e-08 FALSE TRUE
ENST00000687574 ENSG00000197535 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO5A protein_coding protein_coding 3.92726 1.84517 5.565679 0.1470747 0.1431644 1.587596 0.44441261 0.21615409 0.57148945 0.11955367 0.36028677 1.362447 0.10172500 0.11376667 0.10400000 -0.009766667 9.585943e-01 2.592787e-08 FALSE TRUE
MSTRG.10854.18 ENSG00000197535 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO5A protein_coding   3.92726 1.84517 5.565679 0.1470747 0.1431644 1.587596 0.70683653 0.00000000 1.07857757 0.00000000 0.19217351 6.766300 0.12130417 0.00000000 0.19286667 0.192866667 3.517403e-07 2.592787e-08 FALSE TRUE
MSTRG.10854.5 ENSG00000197535 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO5A protein_coding   3.92726 1.84517 5.565679 0.1470747 0.1431644 1.587596 0.30908617 0.21170903 0.50138193 0.10610697 0.50138193 1.205734 0.08992083 0.12453333 0.09146667 -0.033066667 5.590734e-01 2.592787e-08 FALSE TRUE
MSTRG.10854.7 ENSG00000197535 HEK293_OSMI2_2hA HEK293_TMG_2hB MYO5A protein_coding   3.92726 1.84517 5.565679 0.1470747 0.1431644 1.587596 0.58354942 0.00000000 1.02231909 0.00000000 0.51391191 6.689745 0.10530417 0.00000000 0.18216667 0.182166667 3.202162e-01 2.592787e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197535 E001 0.0000000       15 52307281 52307282 2 -      
ENSG00000197535 E002 0.0000000       15 52307283 52307285 3 -      
ENSG00000197535 E003 0.1515154 0.0423592531 1.000000e+00   15 52307286 52307295 10 - 0.067 0.000 -9.048
ENSG00000197535 E004 1.1834139 0.0121989077 4.356795e-02 9.758823e-02 15 52307296 52307313 18 - 0.177 0.548 2.335
ENSG00000197535 E005 27.9857515 0.0009102203 4.605115e-16 1.816039e-14 15 52307314 52307582 269 - 1.187 1.744 1.919
ENSG00000197535 E006 247.4250288 0.0028896286 5.071138e-09 6.611009e-08 15 52307583 52312664 5082 - 2.270 2.467 0.658
ENSG00000197535 E007 19.4472678 0.0660748480 2.552123e-01 3.920417e-01 15 52312665 52313108 444 - 1.272 1.128 -0.511
ENSG00000197535 E008 1.9765949 0.1435322827 2.732522e-01 4.122589e-01 15 52313109 52313109 1 - 0.479 0.213 -1.668
ENSG00000197535 E009 1.9765949 0.1435322827 2.732522e-01 4.122589e-01 15 52313110 52313110 1 - 0.479 0.213 -1.668
ENSG00000197535 E010 2.4613301 0.2727381934 5.697600e-01 6.962836e-01 15 52313111 52313125 15 - 0.526 0.357 -0.890
ENSG00000197535 E011 2.4592538 0.5169192858 6.649515e-01 7.726844e-01 15 52313126 52313128 3 - 0.527 0.357 -0.887
ENSG00000197535 E012 4.2778742 0.1309390610 8.148765e-01 8.827079e-01 15 52313129 52313162 34 - 0.656 0.686 0.123
ENSG00000197535 E013 3.3878098 0.1454640243 4.567038e-01 5.970929e-01 15 52313163 52313170 8 - 0.547 0.686 0.609
ENSG00000197535 E014 3.4137324 0.0818771194 2.777611e-01 4.173719e-01 15 52313171 52313173 3 - 0.525 0.738 0.929
ENSG00000197535 E015 3.2622170 0.0568901936 2.168347e-01 3.465882e-01 15 52313174 52313174 1 - 0.502 0.737 1.034
ENSG00000197535 E016 3.2622170 0.0568901936 2.168347e-01 3.465882e-01 15 52313175 52313178 4 - 0.502 0.737 1.034
ENSG00000197535 E017 3.4073896 0.0277454969 2.424271e-01 3.770139e-01 15 52313179 52313180 2 - 0.524 0.736 0.924
ENSG00000197535 E018 6.8984151 0.0212566363 2.183369e-01 3.484074e-01 15 52313181 52313194 14 - 0.780 0.967 0.717
ENSG00000197535 E019 7.3339332 0.0078454215 3.012443e-01 4.430325e-01 15 52313195 52313212 18 - 0.814 0.966 0.577
ENSG00000197535 E020 9.5106532 0.0023481227 2.243714e-01 3.556522e-01 15 52313213 52313260 48 - 0.914 1.071 0.581
ENSG00000197535 E021 11.3090003 0.0015250381 1.353572e-01 2.416143e-01 15 52313261 52313281 21 - 0.979 1.155 0.640
ENSG00000197535 E022 54.3428755 0.0025014858 1.060007e-06 8.748591e-06 15 52313282 52313675 394 - 1.593 1.875 0.955
ENSG00000197535 E023 15.0729894 0.0083097418 6.977889e-02 1.430067e-01 15 52313676 52313695 20 - 1.087 1.287 0.711
ENSG00000197535 E024 26.7560338 0.0009696631 6.779292e-03 2.064851e-02 15 52313696 52313848 153 - 1.317 1.530 0.737
ENSG00000197535 E025 21.4689040 0.0213196297 4.562029e-01 5.966563e-01 15 52314123 52314203 81 - 1.257 1.356 0.346
ENSG00000197535 E026 0.2214452 0.0397432454 1.209464e-01   15 52314204 52315323 1120 - 0.000 0.213 12.995
ENSG00000197535 E027 30.1999838 0.0088444920 2.457209e-01 3.808950e-01 15 52317048 52317222 175 - 1.399 1.514 0.394
ENSG00000197535 E028 0.0000000       15 52317223 52318362 1140 -      
ENSG00000197535 E029 39.6906036 0.0040925634 5.043590e-02 1.099430e-01 15 52319060 52319342 283 - 1.507 1.655 0.507
ENSG00000197535 E030 0.1451727 0.0433763788 1.000000e+00   15 52319343 52321358 2016 - 0.067 0.000 -11.580
ENSG00000197535 E031 30.5770110 0.0006942232 6.625348e-02 1.371466e-01 15 52321359 52321509 151 - 1.394 1.538 0.498
ENSG00000197535 E032 0.0000000       15 52321510 52321818 309 -      
ENSG00000197535 E033 19.5604563 0.0012116488 6.158760e-02 1.293031e-01 15 52323355 52323444 90 - 1.201 1.376 0.614
ENSG00000197535 E034 0.0000000       15 52323445 52323576 132 -      
ENSG00000197535 E035 0.0000000       15 52323577 52323937 361 -      
ENSG00000197535 E036 28.6327011 0.0050126081 3.454580e-01 4.895537e-01 15 52327852 52328006 155 - 1.385 1.478 0.323
ENSG00000197535 E037 28.2245254 0.0007386380 2.075268e-01 3.355209e-01 15 52330353 52330499 147 - 1.370 1.479 0.378
ENSG00000197535 E038 0.4418608 0.0278067586 5.419071e-01 6.727787e-01 15 52330500 52331698 1199 - 0.177 0.000 -13.147
ENSG00000197535 E039 0.1451727 0.0433763788 1.000000e+00   15 52331699 52331836 138 - 0.067 0.000 -11.580
ENSG00000197535 E040 18.6105754 0.0193144558 2.378931e-01 3.716897e-01 15 52336463 52336556 94 - 1.187 1.330 0.503
ENSG00000197535 E041 0.2987644 0.0269810446 1.000000e+00   15 52336557 52337809 1253 - 0.125 0.000 -12.616
ENSG00000197535 E042 1.1940256 0.0126030101 5.133742e-01 6.481998e-01 15 52337810 52337884 75 - 0.337 0.213 -0.889
ENSG00000197535 E043 0.0000000       15 52337885 52340195 2311 -      
ENSG00000197535 E044 23.9782874 0.0168258384 4.288847e-01 5.716147e-01 15 52340196 52340394 199 - 1.306 1.401 0.330
ENSG00000197535 E045 0.4783925 0.0208936608 6.219111e-01 7.388056e-01 15 52340395 52340704 310 - 0.125 0.213 0.920
ENSG00000197535 E046 5.4877438 0.0088554386 3.073503e-02 7.339518e-02 15 52343117 52343197 81 - 0.825 0.462 -1.584
ENSG00000197535 E047 17.4145318 0.0010790633 8.118461e-01 8.806215e-01 15 52346361 52346461 101 - 1.187 1.226 0.138
ENSG00000197535 E048 1.3768759 0.0441723266 4.346259e-01 5.769441e-01 15 52346462 52348717 2256 - 0.369 0.213 -1.081
ENSG00000197535 E049 0.0000000       15 52348718 52348817 100 -      
ENSG00000197535 E050 3.6718020 0.0059642082 2.560392e-01 3.929987e-01 15 52348818 52348826 9 - 0.655 0.462 -0.888
ENSG00000197535 E051 0.8084787 0.1351820705 1.000000e+00 1.000000e+00 15 52348827 52350529 1703 - 0.222 0.215 -0.065
ENSG00000197535 E052 21.8592189 0.0008262985 2.059694e-02 5.274124e-02 15 52351254 52351481 228 - 1.334 1.135 -0.701
ENSG00000197535 E053 13.2735432 0.0015615833 1.185177e-01 2.178187e-01 15 52353605 52353658 54 - 1.126 0.965 -0.589
ENSG00000197535 E054 21.4183581 0.0030562609 3.068539e-01 4.490330e-01 15 52353871 52354014 144 - 1.303 1.226 -0.268
ENSG00000197535 E055 0.0000000       15 52357499 52359967 2469 -      
ENSG00000197535 E056 21.9191944 0.0017462128 1.077224e-02 3.062010e-02 15 52359968 52360069 102 - 1.341 1.115 -0.798
ENSG00000197535 E057 12.2501382 0.0222374823 3.303383e-02 7.787268e-02 15 52360070 52360081 12 - 1.115 0.826 -1.079
ENSG00000197535 E058 11.3749494 0.0076260574 4.022280e-02 9.144245e-02 15 52364554 52364556 3 - 1.081 0.826 -0.954
ENSG00000197535 E059 20.2573974 0.0057036457 4.425896e-02 9.886367e-02 15 52364557 52364702 146 - 1.302 1.115 -0.664
ENSG00000197535 E060 13.6675978 0.0012613996 2.191865e-02 5.550699e-02 15 52367031 52367124 94 - 1.153 0.901 -0.924
ENSG00000197535 E061 0.0000000       15 52369922 52370168 247 -      
ENSG00000197535 E062 26.3315679 0.0007789220 5.203436e-02 1.127773e-01 15 52370169 52370417 249 - 1.402 1.257 -0.505
ENSG00000197535 E063 28.0522873 0.0007471053 2.908831e-02 7.017310e-02 15 52372124 52372363 240 - 1.433 1.272 -0.559
ENSG00000197535 E064 0.0000000       15 52372957 52375303 2347 -      
ENSG00000197535 E065 21.5573496 0.0008805781 1.350173e-03 5.143913e-03 15 52375304 52375460 157 - 1.344 1.046 -1.057
ENSG00000197535 E066 25.3118623 0.0007914950 1.103477e-02 3.124539e-02 15 52376347 52376558 212 - 1.397 1.192 -0.716
ENSG00000197535 E067 0.0000000       15 52376559 52376787 229 -      
ENSG00000197535 E068 0.1482932 0.0421340291 1.218282e-01   15 52376788 52376945 158 - 0.000 0.213 12.975
ENSG00000197535 E069 0.0000000       15 52376946 52377627 682 -      
ENSG00000197535 E070 0.0000000       15 52379295 52379624 330 -      
ENSG00000197535 E071 14.6830501 0.0011635981 1.423590e-01 2.512553e-01 15 52379625 52379733 109 - 1.163 1.021 -0.513
ENSG00000197535 E072 12.8004744 0.0014100258 1.591787e-01 2.740219e-01 15 52379822 52379908 87 - 1.110 0.965 -0.529
ENSG00000197535 E073 0.2966881 0.0269994056 1.000000e+00   15 52379909 52381022 1114 - 0.125 0.000 -12.616
ENSG00000197535 E074 1.9229078 0.1338016031 5.980436e-01 7.197152e-01 15 52381023 52381384 362 - 0.399 0.540 0.712
ENSG00000197535 E075 0.2987644 0.0269810446 1.000000e+00   15 52381385 52381542 158 - 0.125 0.000 -12.616
ENSG00000197535 E076 0.2987644 0.0269810446 1.000000e+00   15 52381543 52381704 162 - 0.125 0.000 -12.616
ENSG00000197535 E077 1.7757460 0.0078628696 6.579170e-01 7.671878e-01 15 52381705 52382181 477 - 0.369 0.462 0.506
ENSG00000197535 E078 1.5469244 0.0093852492 1.305642e-01 2.349405e-01 15 52382182 52382777 596 - 0.264 0.549 1.600
ENSG00000197535 E079 0.4751703 0.0205438935 9.597560e-02 1.843446e-01 15 52382778 52383090 313 - 0.067 0.355 2.919
ENSG00000197535 E080 15.5116048 0.0015479413 1.046186e-02 2.988942e-02 15 52383091 52383188 98 - 1.206 0.934 -0.987
ENSG00000197535 E081 20.5830611 0.0009296222 2.029536e-04 9.764566e-04 15 52384161 52384322 162 - 1.334 0.965 -1.322
ENSG00000197535 E082 0.1482932 0.0421340291 1.218282e-01   15 52387750 52387828 79 - 0.000 0.213 12.975
ENSG00000197535 E083 15.3792051 0.0012666957 1.174145e-02 3.291743e-02 15 52387829 52387912 84 - 1.201 0.934 -0.971
ENSG00000197535 E084 0.0000000       15 52387913 52389237 1325 -      
ENSG00000197535 E085 17.1401879 0.0010753507 5.577190e-02 1.192988e-01 15 52389238 52389363 126 - 1.228 1.047 -0.650
ENSG00000197535 E086 0.0000000       15 52389364 52390081 718 -      
ENSG00000197535 E087 18.6387435 0.0009411094 7.101826e-03 2.149267e-02 15 52391930 52392070 141 - 1.280 1.021 -0.928
ENSG00000197535 E088 0.0000000       15 52393401 52396315 2915 -      
ENSG00000197535 E089 13.3073357 0.0013354631 1.267184e-02 3.513769e-02 15 52396316 52396397 82 - 1.148 0.865 -1.044
ENSG00000197535 E090 0.0000000       15 52396398 52396613 216 -      
ENSG00000197535 E091 0.0000000       15 52396614 52397027 414 -      
ENSG00000197535 E092 0.0000000       15 52397028 52397200 173 -      
ENSG00000197535 E093 26.8369618 0.0060842814 2.018453e-03 7.283201e-03 15 52397201 52397466 266 - 1.433 1.155 -0.976
ENSG00000197535 E094 0.0000000       15 52405108 52405286 179 -      
ENSG00000197535 E095 14.4769478 0.0139107680 4.568883e-02 1.014618e-01 15 52405287 52405393 107 - 1.173 0.934 -0.873
ENSG00000197535 E096 12.1610441 0.0043922113 4.133913e-02 9.350686e-02 15 52407292 52407399 108 - 1.104 0.865 -0.888
ENSG00000197535 E097 11.0814992 0.0015941307 4.947848e-04 2.140031e-03 15 52408059 52408136 78 - 1.098 0.620 -1.867
ENSG00000197535 E098 7.1664926 0.0023064060 3.499279e-03 1.172286e-02 15 52408137 52408140 4 - 0.931 0.462 -1.987
ENSG00000197535 E099 0.5181333 0.0205324852 6.202208e-01 7.374752e-01 15 52408141 52410332 2192 - 0.125 0.213 0.922
ENSG00000197535 E100 21.2019925 0.0026518298 4.058117e-04 1.797139e-03 15 52410333 52410476 144 - 1.344 0.994 -1.250
ENSG00000197535 E101 0.0000000       15 52410477 52410730 254 -      
ENSG00000197535 E102 0.0000000       15 52415116 52415202 87 -      
ENSG00000197535 E103 0.0000000       15 52416005 52416144 140 -      
ENSG00000197535 E104 24.1623285 0.0008044435 1.091728e-04 5.642467e-04 15 52416145 52416301 157 - 1.400 1.046 -1.250
ENSG00000197535 E105 20.4246087 0.0009151384 1.487560e-03 5.596095e-03 15 52425830 52425974 145 - 1.324 1.021 -1.080
ENSG00000197535 E106 6.4848639 0.0033278814 9.404099e-03 2.729092e-02 15 52428398 52428400 3 - 0.886 0.462 -1.817
ENSG00000197535 E107 16.4815902 0.0010787046 3.946330e-03 1.299193e-02 15 52428401 52428569 169 - 1.236 0.934 -1.095
ENSG00000197535 E108 11.0082294 0.0015839349 4.750549e-02 1.047460e-01 15 52433175 52433285 111 - 1.062 0.826 -0.887
ENSG00000197535 E109 0.2924217 0.0274086331 1.000000e+00   15 52524083 52524202 120 - 0.125 0.000 -12.614
ENSG00000197535 E110 0.1515154 0.0423592531 1.000000e+00   15 52526913 52527014 102 - 0.067 0.000 -11.586
ENSG00000197535 E111 5.6360355 0.0031576976 2.113312e-01 3.400668e-01 15 52528780 52529132 353 - 0.803 0.620 -0.758