ENSG00000197451

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355836 ENSG00000197451 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPAB protein_coding protein_coding 495.5162 659.7572 502.904 26.9882 9.390765 -0.3916452 164.07032 237.06285 168.81859 9.042862 9.520977 -0.4897712 0.33119167 0.35970000 0.3353000 -0.02440000 0.6426922123 0.0002136439 FALSE  
ENST00000358344 ENSG00000197451 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPAB protein_coding protein_coding 495.5162 659.7572 502.904 26.9882 9.390765 -0.3916452 285.72335 387.85529 263.97616 18.485960 3.193800 -0.5550934 0.57868750 0.58753333 0.5253333 -0.06220000 0.0227598762 0.0002136439 FALSE  
ENST00000506259 ENSG00000197451 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPAB protein_coding protein_coding 495.5162 659.7572 502.904 26.9882 9.390765 -0.3916452 37.47633 29.22044 61.98984 6.214246 2.100704 1.0847931 0.07114583 0.04416667 0.1233000 0.07913333 0.0002136439 0.0002136439 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197451 E001 41.32570 0.0004988098 2.064203e-05 1.276380e-04 5 178203898 178204532 635 + 1.754 1.503 -0.855
ENSG00000197451 E002 45.68100 0.0004867059 3.956755e-06 2.881507e-05 5 178204533 178204538 6 + 1.800 1.541 -0.880
ENSG00000197451 E003 60.02171 0.0010463875 2.723624e-05 1.636533e-04 5 178204539 178204540 2 + 1.896 1.677 -0.740
ENSG00000197451 E004 204.81165 0.0001852636 9.479035e-76 1.710262e-72 5 178204541 178204543 3 + 2.544 2.054 -1.637
ENSG00000197451 E005 627.16737 0.0119233795 3.277553e-08 3.663043e-07 5 178204544 178204547 4 + 2.961 2.631 -1.100
ENSG00000197451 E006 992.23996 0.0150126060 1.165416e-05 7.627203e-05 5 178204548 178204570 23 + 3.141 2.852 -0.959
ENSG00000197451 E007 1848.69284 0.0183392848 4.422590e-06 3.186212e-05 5 178204571 178204740 170 + 3.426 3.105 -1.067
ENSG00000197451 E008 332.02896 0.0449182641 1.410908e-07 1.393090e-06 5 178204741 178204814 74 + 2.782 2.205 -1.922
ENSG00000197451 E009 616.64474 0.0270489104 2.947448e-06 2.209064e-05 5 178204815 178204817 3 + 2.985 2.584 -1.337
ENSG00000197451 E010 2872.00633 0.0138297946 5.665035e-07 4.960892e-06 5 178204818 178205046 229 + 3.608 3.308 -0.995
ENSG00000197451 E011 34.37370 0.0061317319 2.535251e-05 1.535031e-04 5 178205568 178205841 274 + 1.706 1.392 -1.076
ENSG00000197451 E012 5783.43518 0.0005009751 3.810680e-02 8.755345e-02 5 178205842 178206010 169 + 3.773 3.726 -0.155
ENSG00000197451 E013 8474.69243 0.0001336122 7.837626e-16 3.000838e-14 5 178206732 178206890 159 + 3.893 3.919 0.086
ENSG00000197451 E014 7952.17826 0.0003140695 2.545944e-10 4.185728e-09 5 178207094 178207225 132 + 3.863 3.893 0.099
ENSG00000197451 E015 5939.28361 0.0007631847 7.154684e-05 3.876765e-04 5 178209330 178209432 103 + 3.737 3.765 0.096
ENSG00000197451 E016 1238.11954 0.0026452669 3.763031e-01 5.206310e-01 5 178209433 178209441 9 + 3.073 3.077 0.013
ENSG00000197451 E017 1128.62353 0.0027312090 9.586992e-01 9.781225e-01 5 178209442 178209447 6 + 3.049 3.028 -0.071
ENSG00000197451 E018 2314.55719 0.0017959879 3.183293e-04 1.454151e-03 5 178210132 178210272 141 + 3.310 3.366 0.186
ENSG00000197451 E019 8949.12436 0.0011965952 1.280192e-23 1.215073e-21 5 178210553 178211163 611 + 3.848 3.974 0.418