ENSG00000197444

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374103 ENSG00000197444 HEK293_OSMI2_2hA HEK293_TMG_2hB OGDHL protein_coding protein_coding 9.066131 11.65165 6.96563 0.6244899 0.2838421 -0.7413761 3.5748801 4.7909830 3.3238065 0.47402933 0.33067766 -0.5261595 0.39931667 0.41026667 0.47656667 0.06630000 0.59744385 0.02365761 FALSE TRUE
ENST00000432695 ENSG00000197444 HEK293_OSMI2_2hA HEK293_TMG_2hB OGDHL protein_coding protein_coding 9.066131 11.65165 6.96563 0.6244899 0.2838421 -0.7413761 0.8591450 2.7705016 0.1368342 0.28523097 0.13683418 -4.2430855 0.08658750 0.24156667 0.01963333 -0.22193333 0.02365761 0.02365761 FALSE TRUE
ENST00000490844 ENSG00000197444 HEK293_OSMI2_2hA HEK293_TMG_2hB OGDHL protein_coding processed_transcript 9.066131 11.65165 6.96563 0.6244899 0.2838421 -0.7413761 1.2529506 1.3107821 0.6468835 0.26431399 0.06148492 -1.0076830 0.12977083 0.11080000 0.09386667 -0.01693333 0.83056811 0.02365761 FALSE TRUE
ENST00000496884 ENSG00000197444 HEK293_OSMI2_2hA HEK293_TMG_2hB OGDHL protein_coding processed_transcript 9.066131 11.65165 6.96563 0.6244899 0.2838421 -0.7413761 1.1721061 0.8066298 0.6290522 0.09275069 0.07707111 -0.3537485 0.13169583 0.06876667 0.09033333 0.02156667 0.57703037 0.02365761 FALSE TRUE
MSTRG.3966.8 ENSG00000197444 HEK293_OSMI2_2hA HEK293_TMG_2hB OGDHL protein_coding   9.066131 11.65165 6.96563 0.6244899 0.2838421 -0.7413761 1.3318999 1.4755366 1.1130510 0.18223688 0.31440292 -0.4035608 0.15407500 0.12573333 0.15663333 0.03090000 0.82623974 0.02365761 TRUE TRUE
MSTRG.3966.9 ENSG00000197444 HEK293_OSMI2_2hA HEK293_TMG_2hB OGDHL protein_coding   9.066131 11.65165 6.96563 0.6244899 0.2838421 -0.7413761 0.2353329 0.2511032 0.8346821 0.25110315 0.49398691 1.6937886 0.03007083 0.02220000 0.12356667 0.10136667 0.49674310 0.02365761 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197444 E001 1.1167064 0.0122360231 3.882641e-02 8.886087e-02 10 49734641 49734643 3 - 0.524 0.162 -2.375
ENSG00000197444 E002 3.9492267 0.0275084582 1.674500e-01 2.848859e-01 10 49734644 49734645 2 - 0.789 0.572 -0.917
ENSG00000197444 E003 101.4620693 0.0022399769 1.108335e-07 1.116806e-06 10 49734646 49734964 319 - 1.782 2.025 0.816
ENSG00000197444 E004 72.0752959 0.0003793462 4.617759e-09 6.060832e-08 10 49734965 49735038 74 - 1.596 1.882 0.969
ENSG00000197444 E005 46.6960478 0.0035087712 2.669561e-06 2.020940e-05 10 49735039 49735049 11 - 1.388 1.705 1.083
ENSG00000197444 E006 59.4152973 0.0006130410 1.588910e-07 1.552500e-06 10 49735050 49735107 58 - 1.517 1.800 0.963
ENSG00000197444 E007 37.9954129 0.0005906160 2.641365e-02 6.477317e-02 10 49735108 49735134 27 - 1.443 1.580 0.472
ENSG00000197444 E008 111.2904473 0.0016324396 4.418117e-01 5.834657e-01 10 49735135 49735351 217 - 1.981 2.009 0.094
ENSG00000197444 E009 108.0860810 0.0003404166 6.726792e-02 1.388143e-01 10 49736023 49736177 155 - 1.943 2.008 0.217
ENSG00000197444 E010 96.7493416 0.0003262043 4.271583e-04 1.878761e-03 10 49736357 49736520 164 - 1.842 1.980 0.465
ENSG00000197444 E011 54.7510723 0.0004796230 2.720738e-02 6.641356e-02 10 49737786 49737858 73 - 1.616 1.730 0.385
ENSG00000197444 E012 75.7080406 0.0021053280 1.914643e-01 3.155790e-01 10 49737947 49738072 126 - 1.792 1.852 0.201
ENSG00000197444 E013 12.4532068 0.0173076848 7.094507e-01 8.068248e-01 10 49738073 49738190 118 - 1.104 1.062 -0.155
ENSG00000197444 E014 56.3515320 0.0004469779 4.356513e-01 5.778599e-01 10 49738191 49738262 72 - 1.740 1.697 -0.143
ENSG00000197444 E015 26.7931041 0.0063946229 3.863820e-01 5.305729e-01 10 49738263 49739499 1237 - 1.443 1.371 -0.247
ENSG00000197444 E016 67.9108059 0.0003800791 4.450495e-01 5.866088e-01 10 49739661 49739839 179 - 1.821 1.783 -0.128
ENSG00000197444 E017 67.1316420 0.0093921606 8.565582e-01 9.112893e-01 10 49740710 49740837 128 - 1.798 1.786 -0.042
ENSG00000197444 E018 88.9928876 0.0003704311 5.165178e-01 6.510712e-01 10 49742828 49742978 151 - 1.894 1.917 0.076
ENSG00000197444 E019 11.5401576 0.0015717300 2.330049e-01 3.659963e-01 10 49743571 49743993 423 - 1.135 1.011 -0.450
ENSG00000197444 E020 77.2086150 0.0016249704 7.094288e-01 8.068145e-01 10 49743994 49744122 129 - 1.842 1.856 0.049
ENSG00000197444 E021 63.8933321 0.0005973802 5.947912e-01 7.169671e-01 10 49744650 49744752 103 - 1.754 1.776 0.074
ENSG00000197444 E022 64.5995146 0.0092240943 1.282465e-01 2.317008e-01 10 49745344 49745496 153 - 1.842 1.740 -0.344
ENSG00000197444 E023 62.4473735 0.0004387083 9.437120e-03 2.737500e-02 10 49745798 49745977 180 - 1.842 1.718 -0.416
ENSG00000197444 E024 58.9145289 0.0004203802 1.205845e-03 4.660500e-03 10 49746750 49746878 129 - 1.839 1.683 -0.526
ENSG00000197444 E025 76.7799389 0.0011828311 1.032079e-03 4.069267e-03 10 49747029 49747208 180 - 1.943 1.797 -0.491
ENSG00000197444 E026 42.4664037 0.0069594874 7.757389e-02 1.555707e-01 10 49749726 49749816 91 - 1.676 1.553 -0.419
ENSG00000197444 E027 66.0617618 0.0005984203 5.326112e-03 1.681945e-02 10 49750839 49750985 147 - 1.870 1.740 -0.437
ENSG00000197444 E028 56.4445075 0.0032166907 2.759265e-03 9.549753e-03 10 49751827 49751981 155 - 1.824 1.657 -0.564
ENSG00000197444 E029 47.0680449 0.0101440751 1.662172e-03 6.160491e-03 10 49752133 49752248 116 - 1.779 1.556 -0.755
ENSG00000197444 E030 46.7960811 0.0035975985 5.482987e-04 2.340759e-03 10 49752638 49752740 103 - 1.765 1.559 -0.700
ENSG00000197444 E031 0.5953508 0.0246189022 4.786720e-01 6.170967e-01 10 49756590 49756775 186 - 0.287 0.162 -1.058
ENSG00000197444 E032 46.1375558 0.0005156567 1.130614e-03 4.406545e-03 10 49756776 49756946 171 - 1.743 1.567 -0.598
ENSG00000197444 E033 30.8649996 0.0006503344 4.155690e-03 1.357970e-02 10 49758389 49758593 205 - 1.580 1.393 -0.642
ENSG00000197444 E034 0.8275069 0.6052477516 2.649190e-01 4.029264e-01 10 49761969 49762238 270 - 0.462 0.092 -3.014
ENSG00000197444 E035 3.0354601 0.0053049849 7.533863e-03 2.260016e-02 10 49762239 49762332 94 - 0.821 0.412 -1.831
ENSG00000197444 E036 0.3634088 0.4253550100 5.904609e-01   10 49762333 49762379 47 - 0.001 0.163 8.429