ENSG00000197386

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355072 ENSG00000197386 HEK293_OSMI2_2hA HEK293_TMG_2hB HTT protein_coding protein_coding 31.52475 40.97395 22.82296 3.449921 0.546775 -0.8439413 12.0444012 14.5116693 9.013428 2.6253743 0.54719923 -0.68645985 0.38020000 0.35336667 0.39423333 0.04086667 7.928744e-01 1.615786e-22 FALSE TRUE
ENST00000508321 ENSG00000197386 HEK293_OSMI2_2hA HEK293_TMG_2hB HTT protein_coding retained_intron 31.52475 40.97395 22.82296 3.449921 0.546775 -0.8439413 1.4684869 4.8129788 0.000000 1.8519166 0.00000000 -8.91378065 0.03892917 0.12210000 0.00000000 -0.12210000 7.397688e-07 1.615786e-22 FALSE FALSE
ENST00000512068 ENSG00000197386 HEK293_OSMI2_2hA HEK293_TMG_2hB HTT protein_coding retained_intron 31.52475 40.97395 22.82296 3.449921 0.546775 -0.8439413 1.5690530 1.2658963 1.239509 0.3035966 0.03709156 -0.03014927 0.05314583 0.03160000 0.05430000 0.02270000 2.253136e-01 1.615786e-22 FALSE FALSE
ENST00000513806 ENSG00000197386 HEK293_OSMI2_2hA HEK293_TMG_2hB HTT protein_coding processed_transcript 31.52475 40.97395 22.82296 3.449921 0.546775 -0.8439413 0.6402924 3.2447804 0.000000 3.2447804 0.00000000 -8.34641640 0.01526667 0.06866667 0.00000000 -0.06866667 9.044301e-01 1.615786e-22 FALSE FALSE
MSTRG.24499.10 ENSG00000197386 HEK293_OSMI2_2hA HEK293_TMG_2hB HTT protein_coding   31.52475 40.97395 22.82296 3.449921 0.546775 -0.8439413 2.0073881 0.0000000 4.538421 0.0000000 0.86362954 8.82922203 0.08220833 0.00000000 0.20050000 0.20050000 1.615786e-22 1.615786e-22 FALSE TRUE
MSTRG.24499.13 ENSG00000197386 HEK293_OSMI2_2hA HEK293_TMG_2hB HTT protein_coding   31.52475 40.97395 22.82296 3.449921 0.546775 -0.8439413 1.4667925 0.1738625 1.181592 0.1738625 0.59608467 2.69619139 0.05046250 0.00430000 0.05096667 0.04666667 4.117222e-01 1.615786e-22 TRUE TRUE
MSTRG.24499.17 ENSG00000197386 HEK293_OSMI2_2hA HEK293_TMG_2hB HTT protein_coding   31.52475 40.97395 22.82296 3.449921 0.546775 -0.8439413 3.9874822 1.5924834 4.030917 1.5924834 0.51382482 1.33437342 0.13559167 0.03950000 0.17590000 0.13640000 9.165303e-02 1.615786e-22 TRUE TRUE
MSTRG.24499.18 ENSG00000197386 HEK293_OSMI2_2hA HEK293_TMG_2hB HTT protein_coding   31.52475 40.97395 22.82296 3.449921 0.546775 -0.8439413 4.1936178 11.6275238 0.000000 2.1390645 0.00000000 -10.18456840 0.10892500 0.28763333 0.00000000 -0.28763333 2.750932e-19 1.615786e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197386 E001 0.0000000       4 3041363 3041421 59 +      
ENSG00000197386 E002 0.0000000       4 3041422 3041561 140 +      
ENSG00000197386 E003 0.0000000       4 3041562 3041747 186 +      
ENSG00000197386 E004 0.0000000       4 3041748 3041928 181 +      
ENSG00000197386 E005 0.0000000       4 3041929 3042245 317 +      
ENSG00000197386 E006 0.5933762 0.0287425872 7.734743e-03 2.311236e-02 4 3062476 3062692 217 + 0.442 0.000 -28.551
ENSG00000197386 E007 0.1451727 0.0432835669 2.644736e-01   4 3071236 3071396 161 + 0.159 0.000 -26.612
ENSG00000197386 E008 0.0000000       4 3073358 3073479 122 +      
ENSG00000197386 E009 40.5272893 0.0109570768 4.137386e-12 9.168503e-11 4 3074681 3074972 292 + 1.859 1.354 -1.724
ENSG00000197386 E010 5.2015707 0.1097175999 6.888163e-03 2.093476e-02 4 3074973 3074993 21 + 1.031 0.538 -1.990
ENSG00000197386 E011 3.0656501 0.1254205694 2.227137e-02 5.623708e-02 4 3074994 3075040 47 + 0.830 0.390 -1.985
ENSG00000197386 E012 6.6515048 0.1323468019 2.197181e-01 3.500487e-01 4 3075041 3075088 48 + 0.995 0.757 -0.914
ENSG00000197386 E013 27.2364097 0.0426768257 2.001383e-03 7.230007e-03 4 3086939 3087022 84 + 1.616 1.284 -1.144
ENSG00000197386 E014 57.4614963 0.0310917844 1.126015e-05 7.392835e-05 4 3099274 3099394 121 + 1.966 1.563 -1.363
ENSG00000197386 E015 53.5505532 0.0455616920 5.036849e-04 2.173980e-03 4 3103824 3103883 60 + 1.918 1.553 -1.236
ENSG00000197386 E016 71.7070315 0.0217089680 5.872450e-07 5.126339e-06 4 3105357 3105436 80 + 2.056 1.664 -1.320
ENSG00000197386 E017 97.1081935 0.0289769910 3.522154e-07 3.211848e-06 4 3107285 3107423 139 + 2.205 1.772 -1.453
ENSG00000197386 E018 0.0000000       4 3112864 3113052 189 +      
ENSG00000197386 E019 47.1581070 0.0104445828 2.910934e-10 4.748301e-09 4 3115304 3115328 25 + 1.897 1.464 -1.471
ENSG00000197386 E020 91.9875921 0.0214471864 1.228030e-07 1.226134e-06 4 3115329 3115445 117 + 2.172 1.761 -1.379
ENSG00000197386 E021 109.6137399 0.0132066808 8.632709e-12 1.816551e-10 4 3116085 3116263 179 + 2.255 1.824 -1.445
ENSG00000197386 E022 116.2776506 0.0166467530 5.234108e-11 9.683458e-10 4 3121228 3121399 172 + 2.289 1.839 -1.506
ENSG00000197386 E023 69.4150445 0.0227665361 5.351135e-07 4.706171e-06 4 3121400 3121432 33 + 2.046 1.643 -1.358
ENSG00000197386 E024 2.5432598 0.0062770827 9.101600e-01 9.468969e-01 4 3121433 3121712 280 + 0.507 0.531 0.114
ENSG00000197386 E025 60.1956370 0.0164818463 1.145421e-08 1.397093e-07 4 3122889 3122936 48 + 1.994 1.573 -1.426
ENSG00000197386 E026 3.7934725 0.0042699918 9.299170e-02 1.797983e-01 4 3122937 3123466 530 + 0.800 0.560 -1.011
ENSG00000197386 E027 77.9154197 0.0177997975 2.001798e-07 1.917456e-06 4 3125549 3125629 81 + 2.085 1.708 -1.271
ENSG00000197386 E028 204.2829185 0.0129533546 7.794600e-12 1.652673e-10 4 3127264 3127604 341 + 2.510 2.112 -1.328
ENSG00000197386 E029 8.8761973 0.0040853771 3.795848e-03 1.257057e-02 4 3128339 3129923 1585 + 1.155 0.844 -1.150
ENSG00000197386 E030 100.3377600 0.0004614746 5.212793e-30 8.801675e-28 4 3129924 3129999 76 + 2.205 1.800 -1.360
ENSG00000197386 E031 69.3277791 0.0025928462 2.813498e-16 1.145763e-14 4 3130000 3130047 48 + 2.037 1.648 -1.311
ENSG00000197386 E032 1.2554477 0.0103031802 3.818676e-01 5.261352e-01 4 3130048 3130304 257 + 0.442 0.291 -0.888
ENSG00000197386 E033 117.6031075 0.0115955350 4.600548e-10 7.251519e-09 4 3130305 3130423 119 + 2.257 1.887 -1.238
ENSG00000197386 E034 103.4764624 0.0177550120 5.753063e-07 5.031394e-06 4 3131286 3131397 112 + 2.191 1.844 -1.167
ENSG00000197386 E035 122.5239251 0.0352658695 8.434650e-06 5.699120e-05 4 3131638 3131775 138 + 2.290 1.889 -1.345
ENSG00000197386 E036 143.4537195 0.0340853165 1.721305e-05 1.083628e-04 4 3132562 3132720 159 + 2.345 1.972 -1.249
ENSG00000197386 E037 94.4489588 0.0293011269 8.609115e-05 4.567139e-04 4 3132814 3132911 98 + 2.142 1.815 -1.096
ENSG00000197386 E038 117.1369644 0.0076344078 1.058362e-08 1.298430e-07 4 3134401 3134540 140 + 2.216 1.923 -0.979
ENSG00000197386 E039 102.6202864 0.0111395942 5.202611e-07 4.586014e-06 4 3135904 3135967 64 + 2.159 1.865 -0.988
ENSG00000197386 E040 99.9378743 0.0198139769 4.497247e-05 2.562145e-04 4 3136226 3136326 101 + 2.149 1.856 -0.981
ENSG00000197386 E041 123.2191872 0.0245799462 4.326655e-04 1.900027e-03 4 3140510 3140656 147 + 2.222 1.960 -0.879
ENSG00000197386 E042 0.4438354 0.1902088427 1.000000e+00 1.000000e+00 4 3142745 3142765 21 + 0.159 0.167 0.085
ENSG00000197386 E043 140.0389403 0.0112367861 1.150238e-06 9.429801e-06 4 3142766 3142886 121 + 2.283 2.010 -0.912
ENSG00000197386 E044 108.0936299 0.0087610840 1.738808e-06 1.370779e-05 4 3145152 3145228 77 + 2.165 1.905 -0.872
ENSG00000197386 E045 161.0184500 0.0108641604 2.908124e-05 1.735940e-04 4 3146797 3146948 152 + 2.318 2.091 -0.759
ENSG00000197386 E046 67.6763057 0.0282056808 1.324974e-03 5.059409e-03 4 3148005 3148008 4 + 1.969 1.701 -0.904
ENSG00000197386 E047 191.0630070 0.0131433045 2.556817e-07 2.400185e-06 4 3148009 3148207 199 + 2.432 2.133 -0.998
ENSG00000197386 E048 151.8279673 0.0061683700 6.064473e-10 9.368802e-09 4 3154293 3154419 127 + 2.323 2.040 -0.946
ENSG00000197386 E049 167.8122705 0.0084582041 1.014636e-07 1.028848e-06 4 3157072 3157199 128 + 2.357 2.092 -0.885
ENSG00000197386 E050 145.2531762 0.0129869968 2.559347e-05 1.548037e-04 4 3160282 3160361 80 + 2.286 2.038 -0.830
ENSG00000197386 E051 116.8448316 0.0097067248 6.596251e-06 4.569736e-05 4 3160362 3160392 31 + 2.190 1.942 -0.831
ENSG00000197386 E052 144.6355887 0.0144323567 6.092129e-05 3.360031e-04 4 3172320 3172397 78 + 2.281 2.039 -0.809
ENSG00000197386 E053 222.8275896 0.0107968654 7.515474e-06 5.135195e-05 4 3172908 3173131 224 + 2.463 2.229 -0.783
ENSG00000197386 E054 3.0110447 0.0697376055 3.469246e-01 4.910700e-01 4 3173132 3173218 87 + 0.697 0.528 -0.746
ENSG00000197386 E055 1.1415848 0.0117527898 5.152361e-02 1.118610e-01 4 3173219 3173331 113 + 0.507 0.170 -2.207
ENSG00000197386 E056 135.8091439 0.0007262031 1.624680e-13 4.486092e-12 4 3174721 3174799 79 + 2.248 2.012 -0.789
ENSG00000197386 E057 171.7443571 0.0042246930 4.886214e-10 7.661634e-09 4 3174946 3175107 162 + 2.356 2.109 -0.826
ENSG00000197386 E058 103.8722564 0.0055893321 2.265163e-05 1.386656e-04 4 3177332 3177387 56 + 2.114 1.913 -0.677
ENSG00000197386 E059 105.5034097 0.0094100826 8.054805e-05 4.305145e-04 4 3178298 3178346 49 + 2.129 1.914 -0.721
ENSG00000197386 E060 131.8084520 0.0126125672 7.609087e-03 2.279587e-02 4 3178347 3178446 100 + 2.186 2.037 -0.501
ENSG00000197386 E061 176.8193182 0.0097507791 5.890969e-02 1.247640e-01 4 3180515 3180651 137 + 2.272 2.186 -0.286
ENSG00000197386 E062 0.9514719 0.0274834309 4.776874e-01 6.162006e-01 4 3180652 3180794 143 + 0.159 0.293 1.121
ENSG00000197386 E063 199.8528331 0.0049026359 2.160479e-02 5.485913e-02 4 3182354 3182470 117 + 2.323 2.239 -0.280
ENSG00000197386 E064 217.7033391 0.0031349392 3.341165e-04 1.516795e-03 4 3186597 3186719 123 + 2.383 2.263 -0.399
ENSG00000197386 E065 319.8117978 0.0083456901 4.126723e-02 9.337099e-02 4 3187651 3187886 236 + 2.524 2.444 -0.267
ENSG00000197386 E066 1.4350757 0.0252971183 5.564511e-01 6.850973e-01 4 3187887 3188950 1064 + 0.442 0.341 -0.567
ENSG00000197386 E067 233.3699816 0.0049205664 5.164708e-01 6.510378e-01 4 3188951 3189093 143 + 2.343 2.328 -0.050
ENSG00000197386 E068 306.2679055 0.0048030776 1.486134e-01 2.597793e-01 4 3199732 3199939 208 + 2.482 2.436 -0.153
ENSG00000197386 E069 21.1479951 0.0009496576 2.823727e-06 2.126094e-05 4 3199940 3201450 1511 + 0.973 1.409 1.552
ENSG00000197386 E070 15.3763780 0.0040333835 3.270768e-01 4.705164e-01 4 3202977 3202981 5 + 1.229 1.145 -0.297
ENSG00000197386 E071 28.5553949 0.0064734308 9.993357e-03 2.874731e-02 4 3202982 3203066 85 + 1.550 1.365 -0.639
ENSG00000197386 E072 272.1719354 0.0051681992 8.835143e-02 1.726038e-01 4 3204007 3204148 142 + 2.439 2.382 -0.191
ENSG00000197386 E073 320.9052311 0.0026988509 8.685358e-02 1.703628e-01 4 3206496 3206675 180 + 2.501 2.458 -0.144
ENSG00000197386 E074 287.6499954 0.0001814160 5.753897e-01 7.010022e-01 4 3206807 3206983 177 + 2.426 2.421 -0.019
ENSG00000197386 E075 117.1970820 0.0064477188 9.549890e-01 9.757624e-01 4 3207281 3207285 5 + 2.033 2.037 0.012
ENSG00000197386 E076 213.4106832 0.0001875704 5.422165e-01 6.730174e-01 4 3207286 3207357 72 + 2.301 2.292 -0.030
ENSG00000197386 E077 142.7521653 0.0022308231 2.801692e-01 4.199944e-01 4 3208773 3208802 30 + 2.147 2.114 -0.110
ENSG00000197386 E078 235.4037498 0.0001769100 8.918235e-01 9.349221e-01 4 3208803 3208911 109 + 2.334 2.338 0.011
ENSG00000197386 E079 240.5185459 0.0001709468 4.945375e-01 6.314825e-01 4 3209827 3209949 123 + 2.328 2.352 0.080
ENSG00000197386 E080 0.1482932 0.0422920652 8.875592e-01   4 3211912 3211928 17 + 0.000 0.093 24.561
ENSG00000197386 E081 273.8834791 0.0001747439 1.213847e-03 4.687697e-03 4 3211929 3212142 214 + 2.340 2.424 0.281
ENSG00000197386 E082 224.8924617 0.0008670144 7.759202e-02 1.555955e-01 4 3212564 3212709 146 + 2.273 2.333 0.198
ENSG00000197386 E083 4.8336763 0.0595595918 2.640618e-01 4.020067e-01 4 3212710 3213055 346 + 0.857 0.664 -0.778
ENSG00000197386 E084 1.4446156 0.0095267965 9.239434e-03 2.688554e-02 4 3213917 3213957 41 + 0.613 0.170 -2.693
ENSG00000197386 E085 283.3144505 0.0001876890 2.708533e-01 4.095068e-01 4 3213958 3214135 178 + 2.392 2.425 0.109
ENSG00000197386 E086 5.2894318 0.1203557970 5.571673e-01 6.856363e-01 4 3214136 3214156 21 + 0.859 0.724 -0.534
ENSG00000197386 E087 250.8552852 0.0002037010 3.860589e-03 1.275087e-02 4 3215110 3215211 102 + 2.306 2.385 0.264
ENSG00000197386 E088 366.4146706 0.0001506263 6.586256e-05 3.601727e-04 4 3217765 3217952 188 + 2.462 2.552 0.300
ENSG00000197386 E089 335.0452251 0.0001660246 9.182085e-04 3.678373e-03 4 3220182 3220308 127 + 2.431 2.510 0.263
ENSG00000197386 E090 297.7506823 0.0001722299 8.502567e-03 2.504448e-02 4 3222387 3222487 101 + 2.392 2.459 0.223
ENSG00000197386 E091 360.4168662 0.0013825200 7.034411e-05 3.817781e-04 4 3223406 3223560 155 + 2.439 2.556 0.389
ENSG00000197386 E092 335.2929423 0.0042299120 2.483905e-06 1.893788e-05 4 3223992 3224131 140 + 2.351 2.542 0.639
ENSG00000197386 E093 283.1978867 0.0043885697 2.508549e-06 1.910117e-05 4 3225661 3225743 83 + 2.271 2.471 0.666
ENSG00000197386 E094 188.8200813 0.0048421080 3.202922e-07 2.945553e-06 4 3228615 3228644 30 + 2.063 2.304 0.808
ENSG00000197386 E095 275.5180426 0.0026490651 3.340657e-14 1.016997e-12 4 3228645 3228712 68 + 2.194 2.474 0.936
ENSG00000197386 E096 220.5943649 0.0017069758 9.787374e-18 4.817326e-16 4 3228713 3228745 33 + 2.074 2.382 1.029
ENSG00000197386 E097 8.9957069 0.0057020198 1.428758e-01 2.519607e-01 4 3228746 3228879 134 + 1.081 0.924 -0.579
ENSG00000197386 E098 361.2642874 0.0043916558 2.537270e-08 2.898446e-07 4 3228880 3229009 130 + 2.354 2.581 0.759
ENSG00000197386 E099 379.5272542 0.0056271300 3.533482e-07 3.220857e-06 4 3229887 3230042 156 + 2.377 2.603 0.752
ENSG00000197386 E100 386.9719203 0.0027103485 2.144454e-12 4.983566e-11 4 3233163 3233353 191 + 2.374 2.615 0.800
ENSG00000197386 E101 357.2168551 0.0015983435 5.522609e-15 1.889205e-13 4 3235284 3235398 115 + 2.343 2.579 0.787
ENSG00000197386 E102 1.4456572 0.0334878377 5.621021e-01 6.897713e-01 4 3235424 3235564 141 + 0.275 0.388 0.703
ENSG00000197386 E103 500.5046160 0.0018823470 1.141524e-19 6.998650e-18 4 3235565 3235778 214 + 2.466 2.731 0.880
ENSG00000197386 E104 397.2963828 0.0042647231 8.740704e-13 2.167409e-11 4 3236149 3236254 106 + 2.351 2.635 0.947
ENSG00000197386 E105 377.3882308 0.0034851338 9.436844e-13 2.326326e-11 4 3238447 3238528 82 + 2.342 2.609 0.889
ENSG00000197386 E106 412.2125334 0.0074928864 8.967843e-08 9.183410e-07 4 3238529 3238609 81 + 2.385 2.647 0.872
ENSG00000197386 E107 567.5328397 0.0075988329 5.725289e-11 1.052230e-09 4 3238818 3238978 161 + 2.483 2.795 1.040
ENSG00000197386 E108 2439.4712877 0.0086768874 3.878939e-11 7.334597e-10 4 3239846 3243957 4112 + 3.136 3.424 0.957