ENSG00000197381

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348831 ENSG00000197381 HEK293_OSMI2_2hA HEK293_TMG_2hB ADARB1 protein_coding protein_coding 13.97086 12.03235 13.16113 0.3933188 1.121982 0.1292622 0.5289171 0.0000000 1.96438858 0.0000000 0.25055727 7.6252621 0.04156667 0.00000000 0.148733333 0.14873333 1.727985e-23 1.727985e-23 FALSE TRUE
ENST00000360697 ENSG00000197381 HEK293_OSMI2_2hA HEK293_TMG_2hB ADARB1 protein_coding protein_coding 13.97086 12.03235 13.16113 0.3933188 1.121982 0.1292622 1.9858294 2.6035876 1.57913525 0.1766250 0.39396348 -0.7177896 0.13645000 0.21710000 0.125766667 -0.09133333 2.870580e-01 1.727985e-23 FALSE TRUE
ENST00000389863 ENSG00000197381 HEK293_OSMI2_2hA HEK293_TMG_2hB ADARB1 protein_coding protein_coding 13.97086 12.03235 13.16113 0.3933188 1.121982 0.1292622 1.4070451 1.2111348 0.96938188 0.1584015 0.27032142 -0.3182791 0.10217083 0.10163333 0.074466667 -0.02716667 6.697271e-01 1.727985e-23 FALSE TRUE
ENST00000462214 ENSG00000197381 HEK293_OSMI2_2hA HEK293_TMG_2hB ADARB1 protein_coding processed_transcript 13.97086 12.03235 13.16113 0.3933188 1.121982 0.1292622 1.5514825 2.4175504 0.94880107 0.1198556 0.02430594 -1.3401978 0.11587083 0.20150000 0.072800000 -0.12870000 1.021434e-07 1.727985e-23   FALSE
ENST00000631642 ENSG00000197381 HEK293_OSMI2_2hA HEK293_TMG_2hB ADARB1 protein_coding processed_transcript 13.97086 12.03235 13.16113 0.3933188 1.121982 0.1292622 0.7921091 0.6201826 0.18361842 0.1152285 0.18361842 -1.7025538 0.05257500 0.05123333 0.011933333 -0.03930000 1.608973e-01 1.727985e-23   FALSE
MSTRG.21480.10 ENSG00000197381 HEK293_OSMI2_2hA HEK293_TMG_2hB ADARB1 protein_coding   13.97086 12.03235 13.16113 0.3933188 1.121982 0.1292622 0.9146462 0.0000000 0.00000000 0.0000000 0.00000000 0.0000000 0.06647500 0.00000000 0.000000000 0.00000000   1.727985e-23 FALSE TRUE
MSTRG.21480.21 ENSG00000197381 HEK293_OSMI2_2hA HEK293_TMG_2hB ADARB1 protein_coding   13.97086 12.03235 13.16113 0.3933188 1.121982 0.1292622 0.5624409 0.7095555 0.06260771 0.3635408 0.06260771 -3.3089112 0.04416250 0.06093333 0.005266667 -0.05566667 4.504743e-01 1.727985e-23 TRUE TRUE
MSTRG.21480.31 ENSG00000197381 HEK293_OSMI2_2hA HEK293_TMG_2hB ADARB1 protein_coding   13.97086 12.03235 13.16113 0.3933188 1.121982 0.1292622 1.7087399 0.6172452 2.85858815 0.3691345 0.91239663 2.1932393 0.11720417 0.05050000 0.209266667 0.15876667 2.502600e-01 1.727985e-23 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197381 E001 0.0000000       21 45072423 45072847 425 +      
ENSG00000197381 E002 0.0000000       21 45072848 45073458 611 +      
ENSG00000197381 E003 1.3693727 0.0829579890 5.756495e-01 7.012015e-01 21 45073459 45073852 394 + 0.410 0.307 -0.610
ENSG00000197381 E004 6.8023231 0.0024407603 8.930540e-02 1.740798e-01 21 45073853 45073903 51 + 0.756 0.976 0.848
ENSG00000197381 E005 0.0000000       21 45074569 45074579 11 +      
ENSG00000197381 E006 0.4396707 0.0273547625 9.180736e-02 1.779517e-01 21 45074580 45074589 10 + 0.288 0.000 -11.614
ENSG00000197381 E007 0.5848434 0.0242402277 4.180840e-02 9.437565e-02 21 45074590 45074590 1 + 0.353 0.000 -12.027
ENSG00000197381 E008 1.0308569 0.0160516522 4.540425e-03 1.465466e-02 21 45074591 45074599 9 + 0.504 0.000 -12.826
ENSG00000197381 E009 5.8045028 0.0028137657 3.892623e-06 2.838841e-05 21 45074600 45074711 112 + 1.055 0.430 -2.612
ENSG00000197381 E010 4.6618844 0.0135998920 4.712907e-04 2.050257e-03 21 45074712 45074716 5 + 0.946 0.430 -2.210
ENSG00000197381 E011 9.7756273 0.0317483785 4.178148e-03 1.364447e-02 21 45074717 45074754 38 + 1.179 0.812 -1.363
ENSG00000197381 E012 15.4159216 0.0209550722 7.883601e-03 2.348641e-02 21 45074755 45074793 39 + 1.330 1.053 -0.985
ENSG00000197381 E013 0.4417591 0.1308607151 5.847065e-01 7.085664e-01 21 45113596 45113625 30 + 0.118 0.222 1.091
ENSG00000197381 E014 0.0000000       21 45116932 45116932 1 +      
ENSG00000197381 E015 1.5917749 0.0095746718 4.929319e-01 6.300268e-01 21 45116933 45117038 106 + 0.353 0.481 0.693
ENSG00000197381 E016 0.7782011 0.0159194427 6.902049e-01 7.919545e-01 21 45118418 45118563 146 + 0.288 0.224 -0.476
ENSG00000197381 E017 4.6969244 0.2869860475 7.685675e-01 8.504142e-01 21 45118564 45118619 56 + 0.705 0.792 0.352
ENSG00000197381 E018 12.2476174 0.0014161065 6.959184e-01 7.963785e-01 21 45120794 45120899 106 + 1.131 1.108 -0.082
ENSG00000197381 E019 11.3145492 0.0015583224 3.739961e-01 5.184125e-01 21 45120900 45120959 60 + 1.030 1.131 0.366
ENSG00000197381 E020 34.1414054 0.0041146899 7.474631e-01 8.349577e-01 21 45128402 45128452 51 + 1.542 1.535 -0.024
ENSG00000197381 E021 51.2836547 0.0004557068 4.818939e-01 6.200899e-01 21 45128453 45128573 121 + 1.690 1.738 0.166
ENSG00000197381 E022 0.5483223 0.0209008880 5.415298e-01 6.724998e-01 21 45132215 45132306 92 + 0.118 0.225 1.113
ENSG00000197381 E023 1.1040064 0.4049693590 9.545826e-01 9.755249e-01 21 45133559 45133682 124 + 0.287 0.319 0.208
ENSG00000197381 E024 20.4437028 0.0008923502 8.043232e-05 4.299566e-04 21 45134715 45134795 81 + 1.131 1.453 1.128
ENSG00000197381 E025 16.3577770 0.0012207860 1.289152e-02 3.566227e-02 21 45134796 45134832 37 + 1.111 1.335 0.792
ENSG00000197381 E026 13.5972670 0.0018024503 7.556017e-08 7.856127e-07 21 45137081 45137326 246 + 0.801 1.348 1.999
ENSG00000197381 E027 14.1432413 0.0012520267 6.590931e-01 7.680052e-01 21 45144631 45144962 332 + 1.197 1.172 -0.088
ENSG00000197381 E028 30.1217857 0.0205666857 9.536951e-01 9.749966e-01 21 45145164 45146295 1132 + 1.492 1.502 0.034
ENSG00000197381 E029 10.0308251 0.0017305933 7.135871e-02 1.455893e-01 21 45160101 45160223 123 + 0.930 1.130 0.734
ENSG00000197381 E030 22.2715322 0.0009923291 1.104357e-01 2.061739e-01 21 45171610 45171641 32 + 1.421 1.321 -0.348
ENSG00000197381 E031 25.8179131 0.0007967722 2.490578e-02 6.167908e-02 21 45171642 45171684 43 + 1.492 1.355 -0.475
ENSG00000197381 E032 0.2966881 0.0272323863 2.123424e-01   21 45171685 45171759 75 + 0.211 0.000 -11.052
ENSG00000197381 E033 140.5968701 0.0003218527 5.986578e-06 4.189121e-05 21 45175730 45176409 680 + 2.209 2.090 -0.397
ENSG00000197381 E034 85.4406096 0.0004615645 1.531072e-03 5.736904e-03 21 45176410 45176664 255 + 1.990 1.885 -0.355
ENSG00000197381 E035 3.6826785 0.0047869217 2.578824e-02 6.350685e-02 21 45177067 45177547 481 + 0.459 0.807 1.524
ENSG00000197381 E036 58.6260442 0.0089011327 4.615663e-01 6.015005e-01 21 45180330 45180435 106 + 1.788 1.757 -0.105
ENSG00000197381 E037 31.5251270 0.0015246347 5.369906e-02 1.157247e-01 21 45180436 45180444 9 + 1.561 1.453 -0.369
ENSG00000197381 E038 6.0544289 0.0159677545 1.059144e-06 8.742228e-06 21 45181070 45181232 163 + 1.089 0.371 -3.062
ENSG00000197381 E039 7.6880449 0.0897377190 4.192600e-02 9.459490e-02 21 45181322 45181479 158 + 1.090 0.750 -1.290
ENSG00000197381 E040 5.4923097 0.0498443213 3.510851e-02 8.185088e-02 21 45181480 45181516 37 + 0.962 0.637 -1.291
ENSG00000197381 E041 78.5969678 0.0017087979 3.773195e-01 5.216487e-01 21 45182585 45182753 169 + 1.908 1.884 -0.079
ENSG00000197381 E042 72.0964949 0.0003695112 1.113381e-01 2.075172e-01 21 45183362 45183510 149 + 1.887 1.837 -0.171
ENSG00000197381 E043 55.8621893 0.0004602808 9.935220e-01 1.000000e+00 21 45184474 45184593 120 + 1.744 1.759 0.051
ENSG00000197381 E044 77.8953385 0.0003842334 1.342647e-01 2.400828e-01 21 45184923 45185091 169 + 1.916 1.872 -0.150
ENSG00000197381 E045 74.4178241 0.0042349016 2.156719e-01 3.452073e-01 21 45204555 45204736 182 + 1.831 1.908 0.258
ENSG00000197381 E046 82.6493181 0.0003524832 1.391893e-01 2.469492e-01 21 45220836 45220970 135 + 1.884 1.955 0.241
ENSG00000197381 E047 50.8009650 0.0004912131 4.004175e-02 9.111184e-02 21 45220971 45221014 44 + 1.649 1.764 0.392
ENSG00000197381 E048 72.3715297 0.0004084191 1.157685e-01 2.139060e-01 21 45222018 45222107 90 + 1.819 1.898 0.269
ENSG00000197381 E049 36.3249684 0.0103375298 5.858947e-01 7.095252e-01 21 45222108 45222111 4 + 1.538 1.595 0.195
ENSG00000197381 E050 51.8272373 0.0107964464 2.293330e-01 3.616378e-01 21 45222112 45222280 169 + 1.664 1.763 0.337
ENSG00000197381 E051 53.2417039 0.0004916409 3.278712e-02 7.737967e-02 21 45222281 45222760 480 + 1.777 1.690 -0.295
ENSG00000197381 E052 110.1508743 0.0009494775 1.110982e-01 2.071556e-01 21 45222761 45223577 817 + 2.068 2.027 -0.137
ENSG00000197381 E053 179.3418737 0.0020131179 2.747148e-01 4.139107e-01 21 45223578 45225546 1969 + 2.265 2.244 -0.067
ENSG00000197381 E054 266.6356241 0.0059655889 4.224808e-07 3.792898e-06 21 45225547 45226560 1014 + 2.301 2.516 0.718