ENSG00000197375

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000245407 ENSG00000197375 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC22A5 protein_coding protein_coding 14.93811 14.50392 12.4943 0.288483 0.164782 -0.2150129 8.524320 6.044484 8.944416 0.8786748 0.3448600 0.5645953 0.5756125 0.4188000 0.7154333 0.2966333 0.002404815 0.002404815 FALSE TRUE
ENST00000447841 ENSG00000197375 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC22A5 protein_coding nonsense_mediated_decay 14.93811 14.50392 12.4943 0.288483 0.164782 -0.2150129 2.691704 5.312267 0.500464 0.8493343 0.3404527 -3.3821599 0.1779583 0.3646667 0.0397000 -0.3249667 0.033789085 0.002404815 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197375 E001 13.4285653 0.0107521005 3.755772e-01 5.199989e-01 5 132369710 132369816 107 + 1.168 1.138 -0.107
ENSG00000197375 E002 12.5280041 0.0520373209 9.529225e-01 9.745297e-01 5 132369817 132369838 22 + 1.093 1.156 0.229
ENSG00000197375 E003 21.8761483 0.0008661151 7.554164e-01 8.407596e-01 5 132369839 132369899 61 + 1.313 1.397 0.291
ENSG00000197375 E004 31.2591973 0.0062895690 6.993583e-01 7.991437e-01 5 132369900 132369972 73 + 1.454 1.543 0.306
ENSG00000197375 E005 99.7925119 0.0111666746 1.002592e-01 1.908791e-01 5 132369973 132370365 393 + 2.015 1.983 -0.106
ENSG00000197375 E006 1.6124120 0.0353784281 5.218385e-02 1.130457e-01 5 132376086 132378163 2078 + 0.200 0.589 2.303
ENSG00000197375 E007 1.0339774 0.0525839951 7.150261e-02 1.458352e-01 5 132378164 132378167 4 + 0.440 0.134 -2.277
ENSG00000197375 E008 1.0339774 0.0525839951 7.150261e-02 1.458352e-01 5 132378168 132378235 68 + 0.440 0.134 -2.277
ENSG00000197375 E009 43.5539905 0.0073341939 1.127290e-05 7.400693e-05 5 132378378 132378432 55 + 1.748 1.513 -0.800
ENSG00000197375 E010 48.8358444 0.0014355656 9.903306e-07 8.223994e-06 5 132378433 132378481 49 + 1.780 1.584 -0.666
ENSG00000197375 E011 46.5891762 0.0005143029 1.866435e-16 7.764395e-15 5 132378482 132382470 3989 + 1.826 1.450 -1.280
ENSG00000197375 E012 22.7843520 0.0012159693 2.440590e-01 3.789778e-01 5 132382471 132384146 1676 + 1.387 1.364 -0.080
ENSG00000197375 E013 85.3707973 0.0004362417 9.579662e-06 6.395906e-05 5 132384147 132384301 155 + 1.982 1.875 -0.359
ENSG00000197375 E014 3.9641048 0.0119221600 3.141397e-01 4.568271e-01 5 132384302 132384314 13 + 0.731 0.630 -0.422
ENSG00000197375 E015 2.4076285 0.0059719671 5.260409e-01 6.593199e-01 5 132384315 132384320 6 + 0.560 0.502 -0.274
ENSG00000197375 E016 11.3425573 0.0053396958 1.280407e-01 2.314306e-01 5 132384321 132384849 529 + 1.141 1.047 -0.342
ENSG00000197375 E017 8.6750645 0.0197215094 2.498425e-02 6.184238e-02 5 132384850 132385327 478 + 1.082 0.856 -0.845
ENSG00000197375 E018 50.6176311 0.0017974648 9.032804e-02 1.756395e-01 5 132385328 132385375 48 + 1.719 1.693 -0.089
ENSG00000197375 E019 61.2450954 0.0004646896 1.856594e-01 3.083180e-01 5 132385376 132385499 124 + 1.789 1.792 0.011
ENSG00000197375 E020 7.7331286 0.0850274061 7.947959e-01 8.689151e-01 5 132385500 132386252 753 + 0.934 0.963 0.106
ENSG00000197375 E021 3.4019642 0.0047097678 3.563934e-01 5.007726e-01 5 132386253 132386370 118 + 0.681 0.591 -0.388
ENSG00000197375 E022 10.8649403 0.0051488270 9.417844e-01 9.674088e-01 5 132386371 132386989 619 + 1.039 1.089 0.181
ENSG00000197375 E023 2.2636017 0.0071013338 3.517756e-01 4.959984e-01 5 132386990 132387024 35 + 0.560 0.449 -0.536
ENSG00000197375 E024 44.0212333 0.0036986691 1.177416e-01 2.167083e-01 5 132387025 132387061 37 + 1.665 1.635 -0.103
ENSG00000197375 E025 71.7680782 0.0098736602 3.336162e-01 4.773537e-01 5 132387062 132387151 90 + 1.859 1.863 0.015
ENSG00000197375 E026 0.9200498 0.1555183977 1.387485e-01 2.463656e-01 5 132387813 132387828 16 + 0.111 0.441 2.595
ENSG00000197375 E027 1.1414950 0.0198684237 4.261189e-02 9.583653e-02 5 132387829 132387866 38 + 0.111 0.501 2.893
ENSG00000197375 E028 10.1124129 0.0316659829 6.722747e-01 7.782886e-01 5 132387867 132388910 1044 + 0.990 1.099 0.400
ENSG00000197375 E029 1.0329427 0.0437570477 8.679736e-02 1.702772e-01 5 132388911 132388920 10 + 0.111 0.449 2.632
ENSG00000197375 E030 62.9797651 0.0053830187 7.258996e-01 8.190608e-01 5 132388921 132388959 39 + 1.783 1.827 0.149
ENSG00000197375 E031 70.3178726 0.0005473127 4.780097e-01 6.164610e-01 5 132388960 132389021 62 + 1.803 1.896 0.312
ENSG00000197375 E032 18.8903386 0.0009773667 4.654257e-01 6.051425e-01 5 132389022 132390689 1668 + 1.294 1.298 0.012
ENSG00000197375 E033 83.3224532 0.0003576090 3.283600e-01 4.718428e-01 5 132390690 132390775 86 + 1.910 1.936 0.086
ENSG00000197375 E034 88.9365111 0.0051229373 5.791025e-01 7.040767e-01 5 132390776 132390904 129 + 1.935 1.969 0.113
ENSG00000197375 E035 3.5836555 0.0045227300 4.959945e-01 6.327289e-01 5 132390905 132392432 1528 + 0.681 0.630 -0.218
ENSG00000197375 E036 120.6955589 0.0003477523 2.252297e-01 3.567023e-01 5 132392433 132392615 183 + 2.070 2.095 0.082
ENSG00000197375 E037 3.8014991 0.1527701399 1.136587e-01 2.108571e-01 5 132393234 132393675 442 + 0.440 0.859 1.831
ENSG00000197375 E038 130.4238390 0.0025326135 2.708317e-01 4.094931e-01 5 132393676 132393811 136 + 2.109 2.133 0.078
ENSG00000197375 E039 574.7202289 0.0091143486 1.289463e-07 1.282133e-06 5 132394185 132395613 1429 + 2.617 2.871 0.846