ENSG00000197372

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359788 ENSG00000197372 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF675 protein_coding protein_coding 4.221128 1.487401 6.545642 0.2137617 0.1672182 2.130277 2.8119529 0.4911441 5.1639225 0.03471443 0.30645848 3.3679609 0.5596125 0.3502333 0.78813333 0.4379000 1.296700e-04 1.561457e-06 FALSE TRUE
ENST00000600313 ENSG00000197372 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF675 protein_coding protein_coding 4.221128 1.487401 6.545642 0.2137617 0.1672182 2.130277 0.4761375 0.3338483 0.2418374 0.11020861 0.24183740 -0.4492796 0.1674708 0.2102333 0.03893333 -0.1713000 1.186832e-01 1.561457e-06 FALSE TRUE
ENST00000601010 ENSG00000197372 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF675 protein_coding protein_coding 4.221128 1.487401 6.545642 0.2137617 0.1672182 2.130277 0.5410009 0.6042048 0.5622977 0.15035949 0.06243196 -0.1019541 0.1810792 0.3916000 0.08636667 -0.3052333 1.561457e-06 1.561457e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197372 E001 0.3332198 0.0293060814 1.756113e-01   19 23525631 23526587 957 - 0.052 0.262 2.689
ENSG00000197372 E002 0.0000000       19 23527918 23528014 97 -      
ENSG00000197372 E003 0.0000000       19 23534180 23534317 138 -      
ENSG00000197372 E004 0.1482932 0.0417276000 5.449544e-02   19 23574057 23574232 176 - 0.000 0.261 11.761
ENSG00000197372 E005 7.3169733 0.0022310955 8.039991e-01 8.752842e-01 19 23652801 23652907 107 - 0.796 0.832 0.139
ENSG00000197372 E006 111.8410643 0.0033711616 2.883812e-04 1.332609e-03 19 23652908 23654411 1504 - 1.937 1.788 -0.505
ENSG00000197372 E007 17.0644459 0.0010980278 1.260854e-01 2.287060e-01 19 23654412 23654545 134 - 1.152 0.967 -0.675
ENSG00000197372 E008 23.4495392 0.0009038574 2.175830e-01 3.474794e-01 19 23654546 23654706 161 - 1.277 1.153 -0.440
ENSG00000197372 E009 3.4979224 0.0045840721 5.846973e-01 7.085644e-01 19 23654707 23656721 2015 - 0.536 0.634 0.441
ENSG00000197372 E010 1.2565685 0.0108647759 1.000000e+00 1.000000e+00 19 23656722 23656822 101 - 0.278 0.262 -0.117
ENSG00000197372 E011 1.0330470 0.0119292052 3.462828e-01 4.904291e-01 19 23656823 23657134 312 - 0.278 0.000 -11.246
ENSG00000197372 E012 4.9663140 0.0192038594 6.079100e-09 7.812680e-08 19 23658385 23658672 288 - 0.382 1.202 3.405
ENSG00000197372 E013 0.8984834 0.0576927637 4.507160e-01 5.917743e-01 19 23661935 23662113 179 - 0.248 0.000 -10.925
ENSG00000197372 E014 19.9809303 0.0011970271 1.488028e-01 2.600462e-01 19 23662114 23662209 96 - 1.168 1.301 0.471
ENSG00000197372 E015 21.2945288 0.0102367861 1.344472e-01 2.403455e-01 19 23663032 23663158 127 - 1.190 1.336 0.514
ENSG00000197372 E016 0.0000000       19 23686179 23686381 203 -      
ENSG00000197372 E017 14.8217873 0.0017238436 1.712472e-02 4.521648e-02 19 23687031 23687220 190 - 1.021 1.264 0.872