ENSG00000197363

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359971 ENSG00000197363 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF517 protein_coding protein_coding 2.834167 4.435156 1.6415 0.141588 0.1066428 -1.428457 1.99266376 3.4908899 0.83509105 0.1551743 0.10555429 -2.0505430 0.69149167 0.7909667 0.5104333 -0.28053333 0.0677461204 0.0008359266 FALSE  
ENST00000528012 ENSG00000197363 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF517 protein_coding protein_coding 2.834167 4.435156 1.6415 0.141588 0.1066428 -1.428457 0.04067938 0.0000000 0.08483831 0.0000000 0.02102403 3.2454699 0.01727083 0.0000000 0.0519000 0.05190000 0.0008359266 0.0008359266 FALSE  
ENST00000533965 ENSG00000197363 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF517 protein_coding nonsense_mediated_decay 2.834167 4.435156 1.6415 0.141588 0.1066428 -1.428457 0.29523045 0.4787286 0.26249024 0.2705124 0.14261196 -0.8428291 0.09522500 0.1042333 0.1506667 0.04643333 0.9264705433 0.0008359266 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197363 E001 0.7697675 0.0182926493 1.000000e+00 1.0000000000 8 144798748 144798873 126 + 0.196 0.193 -0.032
ENSG00000197363 E002 0.2214452 0.0383172600 1.000000e+00   8 144798874 144798874 1 + 0.000 0.074 9.933
ENSG00000197363 E003 0.2214452 0.0383172600 1.000000e+00   8 144798875 144798875 1 + 0.000 0.074 9.933
ENSG00000197363 E004 1.4350612 0.0103697472 9.883977e-01 0.9967951954 8 144798876 144798882 7 + 0.331 0.325 -0.035
ENSG00000197363 E005 1.4350612 0.0103697472 9.883977e-01 0.9967951954 8 144798883 144798884 2 + 0.331 0.325 -0.035
ENSG00000197363 E006 2.1004435 0.0075285134 2.049933e-01 0.3323977937 8 144798885 144798893 9 + 0.586 0.362 -1.134
ENSG00000197363 E007 3.5720233 0.0061207852 6.010084e-01 0.7221775589 8 144798894 144798902 9 + 0.646 0.557 -0.396
ENSG00000197363 E008 5.0209027 0.0369514113 4.511098e-01 0.5921085754 8 144798903 144798912 10 + 0.788 0.661 -0.523
ENSG00000197363 E009 5.4637932 0.0719536913 6.185892e-01 0.7361912010 8 144798913 144798916 4 + 0.789 0.701 -0.356
ENSG00000197363 E010 11.4533090 0.0016231231 6.378635e-01 0.7516550498 8 144798917 144798937 21 + 1.052 0.996 -0.206
ENSG00000197363 E011 3.8385213 0.0783959214 5.364127e-01 0.6681731449 8 144799328 144799376 49 + 0.699 0.581 -0.506
ENSG00000197363 E012 2.6509559 0.0778326614 2.707650e-01 0.4094135795 8 144799377 144799411 35 + 0.646 0.431 -1.011
ENSG00000197363 E013 6.1174470 0.0034844303 3.765132e-01 0.5208246258 8 144799412 144799503 92 + 0.862 0.737 -0.494
ENSG00000197363 E014 17.4856862 0.0010927068 8.585452e-01 0.9127342051 8 144802870 144802887 18 + 1.200 1.179 -0.074
ENSG00000197363 E015 24.6608046 0.0008760256 9.396504e-01 0.9660862836 8 144802888 144802947 60 + 1.333 1.323 -0.036
ENSG00000197363 E016 3.8792333 0.0044071141 2.865835e-01 0.4270014079 8 144802948 144803640 693 + 0.746 0.578 -0.715
ENSG00000197363 E017 27.3594051 0.0009917338 7.172945e-01 0.8127261658 8 144803641 144803767 127 + 1.397 1.366 -0.108
ENSG00000197363 E018 2.4293958 0.0089714448 7.459030e-01 0.8338049174 8 144803768 144804124 357 + 0.516 0.456 -0.298
ENSG00000197363 E019 15.4678896 0.0070466981 2.570467e-01 0.3940916109 8 144804125 144804145 21 + 1.230 1.115 -0.411
ENSG00000197363 E020 30.6874722 0.0007367861 2.084783e-01 0.3366455265 8 144804146 144804238 93 + 1.487 1.397 -0.311
ENSG00000197363 E021 3.9008764 0.0043852637 5.380148e-01 0.6694819957 8 144806964 144807190 227 + 0.699 0.599 -0.429
ENSG00000197363 E022 98.8389332 0.0005316838 7.868503e-01 0.8635074625 8 144807191 144808486 1296 + 1.905 1.911 0.019
ENSG00000197363 E023 65.4735483 0.0004226497 6.146072e-02 0.1290916250 8 144808487 144809217 731 + 1.664 1.752 0.299
ENSG00000197363 E024 94.9868928 0.0023067092 1.745494e-03 0.0064258100 8 144809218 144810105 888 + 1.785 1.921 0.458
ENSG00000197363 E025 0.5159433 0.1981949880 1.729252e-01 0.2919956647 8 144810106 144810267 162 + 0.331 0.075 -2.601
ENSG00000197363 E026 0.7427016 0.0154224308 3.862272e-04 0.0017215563 8 144810268 144810791 524 + 0.586 0.000 -15.272
ENSG00000197363 E027 1.4038175 0.0096876284 5.489408e-05 0.0003061473 8 144810792 144811412 621 + 0.746 0.074 -4.620
ENSG00000197363 E028 0.0000000       8 144811413 144811482 70 +      
ENSG00000197363 E029 0.0000000       8 144811483 144811622 140 +      
ENSG00000197363 E030 0.2214452 0.0383172600 1.000000e+00   8 144811623 144811692 70 + 0.000 0.074 9.933
ENSG00000197363 E031 0.2214452 0.0383172600 1.000000e+00   8 144811693 144811761 69 + 0.000 0.074 9.933
ENSG00000197363 E032 0.0000000       8 144811762 144811831 70 +      
ENSG00000197363 E033 0.2214452 0.0383172600 1.000000e+00   8 144811832 144811901 70 + 0.000 0.074 9.933
ENSG00000197363 E034 0.0000000       8 144811902 144811971 70 +      
ENSG00000197363 E035 0.1451727 0.0433672966 1.523048e-01   8 144811972 144812041 70 + 0.196 0.000 -13.051
ENSG00000197363 E036 0.1451727 0.0433672966 1.523048e-01   8 144812042 144812111 70 + 0.196 0.000 -13.051
ENSG00000197363 E037 0.1451727 0.0433672966 1.523048e-01   8 144812112 144812181 70 + 0.196 0.000 -13.051
ENSG00000197363 E038 0.0000000       8 144812182 144812251 70 +      
ENSG00000197363 E039 0.0000000       8 144812252 144812321 70 +      
ENSG00000197363 E040 0.0000000       8 144812322 144812391 70 +      
ENSG00000197363 E041 0.0000000       8 144812392 144812461 70 +      
ENSG00000197363 E042 0.7718584 0.0165511107 9.828066e-02 0.1879148123 8 144812462 144813319 858 + 0.433 0.137 -2.207