ENSG00000197355

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360271 ENSG00000197355 HEK293_OSMI2_2hA HEK293_TMG_2hB UAP1L1 protein_coding protein_coding 8.116501 10.21575 8.220951 0.6509468 0.2721134 -0.3130752 1.669167 1.3332586 1.5711056 0.36900959 0.3444686 0.2351967 0.2096000 0.12713333 0.18973333 0.06260000 5.784820e-01 1.074628e-09 FALSE TRUE
ENST00000409858 ENSG00000197355 HEK293_OSMI2_2hA HEK293_TMG_2hB UAP1L1 protein_coding protein_coding 8.116501 10.21575 8.220951 0.6509468 0.2721134 -0.3130752 1.873054 2.5548053 1.7964970 0.57703144 0.1663639 -0.5056545 0.2242500 0.24606667 0.22030000 -0.02576667 9.128513e-01 1.074628e-09 FALSE TRUE
ENST00000474787 ENSG00000197355 HEK293_OSMI2_2hA HEK293_TMG_2hB UAP1L1 protein_coding retained_intron 8.116501 10.21575 8.220951 0.6509468 0.2721134 -0.3130752 1.592814 0.9122345 2.1437725 0.08076491 0.1398789 1.2236604 0.2101583 0.08916667 0.26040000 0.17123333 1.074628e-09 1.074628e-09 TRUE TRUE
MSTRG.33668.1 ENSG00000197355 HEK293_OSMI2_2hA HEK293_TMG_2hB UAP1L1 protein_coding   8.116501 10.21575 8.220951 0.6509468 0.2721134 -0.3130752 1.403674 1.3329296 2.0320608 0.69208322 0.3183787 0.6046422 0.1671000 0.13353333 0.24950000 0.11596667 3.757425e-01 1.074628e-09 FALSE TRUE
MSTRG.33668.5 ENSG00000197355 HEK293_OSMI2_2hA HEK293_TMG_2hB UAP1L1 protein_coding   8.116501 10.21575 8.220951 0.6509468 0.2721134 -0.3130752 1.234876 4.0111669 0.2111648 1.15448187 0.1063148 -4.1844204 0.1451083 0.39676667 0.02516667 -0.37160000 8.086923e-03 1.074628e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197355 E001 4.201107 0.0756180827 5.276235e-02 1.140693e-01 9 137077501 137077516 16 + 0.855 0.545 -1.296
ENSG00000197355 E002 4.755772 0.1010731058 1.168095e-01 2.154092e-01 9 137077517 137077525 9 + 0.875 0.620 -1.040
ENSG00000197355 E003 6.536717 0.0043703914 2.950562e-04 1.359772e-03 9 137077526 137077586 61 + 1.052 0.644 -1.592
ENSG00000197355 E004 9.614640 0.0067900624 7.625183e-09 9.604840e-08 9 137077587 137077719 133 + 1.266 0.644 -2.356
ENSG00000197355 E005 13.626053 0.0013548679 2.408007e-03 8.486146e-03 9 137077720 137077821 102 + 1.274 1.050 -0.801
ENSG00000197355 E006 16.439943 0.0011192973 6.408889e-01 7.540288e-01 9 137078050 137078140 91 + 1.224 1.233 0.032
ENSG00000197355 E007 21.118203 0.0011480727 8.202561e-01 8.865987e-01 9 137078141 137078220 80 + 1.312 1.344 0.110
ENSG00000197355 E008 17.449191 0.0147207807 9.995745e-01 1.000000e+00 9 137078221 137078254 34 + 1.224 1.274 0.175
ENSG00000197355 E009 3.994196 0.0553763119 2.373856e-02 5.927584e-02 9 137078255 137078286 32 + 0.855 0.503 -1.500
ENSG00000197355 E010 8.386343 0.0022879900 1.155455e-03 4.489838e-03 9 137078287 137078501 215 + 1.113 0.797 -1.187
ENSG00000197355 E011 45.379625 0.0005308148 4.118279e-01 5.553771e-01 9 137078502 137078598 97 + 1.651 1.659 0.025
ENSG00000197355 E012 43.982343 0.0005757378 3.529852e-01 4.972302e-01 9 137078599 137078677 79 + 1.579 1.679 0.339
ENSG00000197355 E013 69.465595 0.0003964358 2.882870e-01 4.288549e-01 9 137078976 137079148 173 + 1.780 1.875 0.322
ENSG00000197355 E014 85.286474 0.0003420039 9.039317e-02 1.757408e-01 9 137079256 137079449 194 + 1.934 1.921 -0.044
ENSG00000197355 E015 41.431165 0.0005531588 1.327770e-15 4.945772e-14 9 137079450 137080001 552 + 1.797 1.411 -1.315
ENSG00000197355 E016 82.491407 0.0003556721 2.989299e-01 4.404128e-01 9 137080002 137080142 141 + 1.905 1.916 0.036
ENSG00000197355 E017 28.244240 0.0006743725 1.339678e-12 3.217519e-11 9 137080143 137080688 546 + 1.648 1.233 -1.434
ENSG00000197355 E018 69.815619 0.0004320032 2.581527e-01 3.953746e-01 9 137080689 137080874 186 + 1.782 1.880 0.331
ENSG00000197355 E019 43.484617 0.0005495195 5.916568e-01 7.143842e-01 9 137081998 137082064 67 + 1.595 1.673 0.266
ENSG00000197355 E020 11.425578 0.0015730467 7.343026e-05 3.966566e-04 9 137082065 137082636 572 + 1.250 0.909 -1.236
ENSG00000197355 E021 562.306491 0.0046379934 1.204061e-07 1.204742e-06 9 137082637 137084539 1903 + 2.640 2.810 0.564