ENSG00000197329

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358912 ENSG00000197329 HEK293_OSMI2_2hA HEK293_TMG_2hB PELI1 protein_coding protein_coding 4.226896 1.958097 6.848681 0.1173591 0.2292214 1.80113 4.012278 1.958097 6.093441 0.1173591 0.05479408 1.632821 0.9610292 1 0.8913 -0.1087 0.0001839237 0.0001839237 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197329 E001 262.324411 0.0020898259 5.505585e-20 3.489517e-18 2 64092652 64095268 2617 - 2.305 2.506 0.669
ENSG00000197329 E002 55.579951 0.0009725727 3.557236e-02 8.275406e-02 2 64096125 64096313 189 - 1.716 1.635 -0.277
ENSG00000197329 E003 48.934521 0.0032387565 1.083608e-02 3.077202e-02 2 64096413 64096610 198 - 1.671 1.541 -0.444
ENSG00000197329 E004 31.702979 0.0188150608 9.895170e-03 2.850598e-02 2 64100398 64100499 102 - 1.511 1.280 -0.802
ENSG00000197329 E005 1.852021 0.0077591415 1.612153e-01 2.766831e-01 2 64104554 64104597 44 - 0.468 0.205 -1.686
ENSG00000197329 E006 30.235777 0.0007237677 1.630966e-03 6.060246e-03 2 64104701 64104830 130 - 1.488 1.280 -0.721
ENSG00000197329 E007 0.737403 0.0156647383 8.512825e-01 9.077820e-01 2 64106178 64106299 122 - 0.231 0.204 -0.228
ENSG00000197329 E008 27.651930 0.0007070596 9.714157e-05 5.086562e-04 2 64108240 64108351 112 - 1.462 1.171 -1.016
ENSG00000197329 E009 14.106718 0.0012817960 3.027875e-04 1.390868e-03 2 64108352 64108379 28 - 1.203 0.807 -1.467
ENSG00000197329 E010 1.325469 0.0100707375 5.303851e-02 1.145500e-01 2 64143318 64143526 209 - 0.412 0.001 -10.163
ENSG00000197329 E011 27.394191 0.0008289698 3.057702e-04 1.402869e-03 2 64144081 64144420 340 - 1.454 1.189 -0.927