ENSG00000197324

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359591 ENSG00000197324 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP10 protein_coding protein_coding 11.17292 15.54591 9.351617 1.306761 0.2518088 -0.7326327 2.642232 2.306176 2.773426 0.2018041 0.4746872 0.2651165 0.2555125 0.1495000 0.2958667 0.1463667 0.0410055779 0.0002180095 FALSE TRUE
ENST00000553002 ENSG00000197324 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP10 protein_coding retained_intron 11.17292 15.54591 9.351617 1.306761 0.2518088 -0.7326327 3.863956 4.726991 3.819759 0.2467840 0.2186318 -0.3067174 0.3578458 0.3067333 0.4079000 0.1011667 0.0558854971 0.0002180095 FALSE TRUE
MSTRG.9202.1 ENSG00000197324 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP10 protein_coding   11.17292 15.54591 9.351617 1.306761 0.2518088 -0.7326327 1.342551 1.668493 1.114207 0.8815943 0.2453686 -0.5782591 0.1099583 0.0987000 0.1195000 0.0208000 0.8421979777 0.0002180095 FALSE TRUE
MSTRG.9202.3 ENSG00000197324 HEK293_OSMI2_2hA HEK293_TMG_2hB LRP10 protein_coding   11.17292 15.54591 9.351617 1.306761 0.2518088 -0.7326327 3.197581 6.738269 1.422771 0.1327628 0.3234382 -2.2357094 0.2646958 0.4385333 0.1531333 -0.2854000 0.0002180095 0.0002180095 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197324 E001 0.1515154 0.0428506227 2.237151e-01   14 22871649 22871739 91 + 0.171 0.000 -9.466
ENSG00000197324 E002 20.9031538 0.0348779183 3.158265e-01 4.585947e-01 14 22871740 22871824 85 + 1.358 1.250 -0.377
ENSG00000197324 E003 39.8823398 0.0271408978 1.425644e-01 2.515288e-01 14 22871825 22871897 73 + 1.649 1.514 -0.460
ENSG00000197324 E004 43.8143749 0.0256765795 2.256317e-01 3.571479e-01 14 22871898 22871938 41 + 1.672 1.564 -0.368
ENSG00000197324 E005 105.4063095 0.0088036812 3.910310e-01 5.349793e-01 14 22871939 22872303 365 + 2.005 1.960 -0.150
ENSG00000197324 E006 40.4189720 0.0122453200 4.468939e-01 5.883481e-01 14 22872304 22872337 34 + 1.609 1.552 -0.194
ENSG00000197324 E007 50.7574435 0.0112775972 3.432443e-01 4.873024e-01 14 22872738 22872782 45 + 1.714 1.647 -0.228
ENSG00000197324 E008 0.4031496 0.0244865115 5.068785e-01 6.425118e-01 14 22873085 22873310 226 + 0.000 0.158 10.796
ENSG00000197324 E009 97.0424270 0.0054105864 1.274335e-01 2.305771e-01 14 22873311 22873446 136 + 1.996 1.918 -0.262
ENSG00000197324 E010 92.4202955 0.0017107256 2.560121e-02 6.312324e-02 14 22875055 22875135 81 + 1.988 1.890 -0.329
ENSG00000197324 E011 117.8565116 0.0064838495 9.391310e-02 1.812450e-01 14 22875136 22875245 110 + 2.084 1.998 -0.286
ENSG00000197324 E012 117.8635202 0.0003231450 1.400851e-02 3.824680e-02 14 22875355 22875465 111 + 2.084 1.996 -0.297
ENSG00000197324 E013 456.8392505 0.0001290981 3.851038e-02 8.829544e-02 14 22875466 22876372 907 + 2.634 2.596 -0.128
ENSG00000197324 E014 65.3131228 0.0004596751 7.323042e-01 8.237860e-01 14 22876689 22876716 28 + 1.781 1.762 -0.067
ENSG00000197324 E015 100.8197511 0.0003062701 2.516742e-01 3.879394e-01 14 22876717 22876818 102 + 1.923 1.964 0.138
ENSG00000197324 E016 129.3958462 0.0012993813 2.817511e-03 9.726289e-03 14 22876940 22877053 114 + 1.975 2.087 0.378
ENSG00000197324 E017 109.0095702 0.0052682725 1.174284e-04 6.020693e-04 14 22877054 22877128 75 + 1.831 2.034 0.683
ENSG00000197324 E018 227.4093796 0.0019506579 3.911385e-05 2.259767e-04 14 22877129 22877426 298 + 2.206 2.339 0.446
ENSG00000197324 E019 197.6329162 0.0005002997 1.559097e-04 7.734125e-04 14 22877427 22877596 170 + 2.166 2.274 0.360
ENSG00000197324 E020 273.3747599 0.0031590242 4.895362e-06 3.492419e-05 14 22877597 22877983 387 + 2.266 2.424 0.529
ENSG00000197324 E021 105.5950353 0.0010616181 9.541812e-01 9.752846e-01 14 22877984 22878503 520 + 1.977 1.976 -0.003
ENSG00000197324 E022 19.1764496 0.0532027113 1.913585e-02 4.963620e-02 14 22878504 22878570 67 + 1.455 1.149 -1.072
ENSG00000197324 E023 47.4211980 0.0032378912 2.300755e-10 3.810729e-09 14 22878571 22879198 628 + 1.861 1.496 -1.237
ENSG00000197324 E024 203.3639475 0.0067796926 2.908770e-02 7.017310e-02 14 22879199 22881713 2515 + 2.331 2.232 -0.331