ENSG00000197323

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358465 ENSG00000197323 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM33 protein_coding protein_coding 12.93685 3.941506 21.25932 0.1618637 0.4061181 2.4283 7.2980967 3.1558881 12.4462005 0.14406930 0.3215472 1.9761819 0.6349208 0.80593333 0.58546667 -0.22046667 5.994655e-02 9.984697e-12 FALSE TRUE
ENST00000369543 ENSG00000197323 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM33 protein_coding protein_coding 12.93685 3.941506 21.25932 0.1618637 0.4061181 2.4283 2.2458117 0.2644759 3.5141831 0.08540675 0.1946700 3.6825377 0.1291000 0.06576667 0.16543333 0.09966667 6.234189e-03 9.984697e-12 FALSE TRUE
ENST00000448034 ENSG00000197323 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM33 protein_coding protein_coding 12.93685 3.941506 21.25932 0.1618637 0.4061181 2.4283 2.0166542 0.0235036 3.4722483 0.01478924 0.2410917 6.6995589 0.1054292 0.00570000 0.16323333 0.15753333 9.984697e-12 9.984697e-12 FALSE TRUE
ENST00000478032 ENSG00000197323 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM33 protein_coding processed_transcript 12.93685 3.941506 21.25932 0.1618637 0.4061181 2.4283 0.5495356 0.4182763 0.7293616 0.15947263 0.1113930 0.7877384 0.0499875 0.10330000 0.03416667 -0.06913333 3.508095e-02 9.984697e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197323 E001 573.270944 0.0049247732 1.072019e-16 4.592738e-15 1 114392790 114396257 3468 - 2.567 2.901 1.110
ENSG00000197323 E002 146.430213 0.0075245273 3.480498e-07 3.177686e-06 1 114396258 114396505 248 - 1.976 2.318 1.143
ENSG00000197323 E003 391.387043 0.0015894198 5.948462e-06 4.164209e-05 1 114396506 114397607 1102 - 2.443 2.635 0.640
ENSG00000197323 E004 66.607021 0.0066989937 1.893109e-02 4.917982e-02 1 114397608 114397731 124 - 1.675 1.893 0.736
ENSG00000197323 E005 110.694778 0.0034632628 3.894937e-02 8.909385e-02 1 114397732 114397860 129 - 1.906 2.078 0.577
ENSG00000197323 E006 3.441733 0.0047701024 1.435248e-01 2.528112e-01 1 114397861 114397939 79 - 0.497 0.792 1.278
ENSG00000197323 E007 62.794963 0.0004181726 9.163802e-01 9.511378e-01 1 114397940 114397990 51 - 1.685 1.764 0.270
ENSG00000197323 E008 97.159122 0.0005853704 5.578953e-02 1.193298e-01 1 114399457 114399609 153 - 1.854 2.011 0.527
ENSG00000197323 E009 41.819452 0.0005116600 3.967365e-01 5.405094e-01 1 114401389 114401463 75 - 1.501 1.629 0.438
ENSG00000197323 E010 78.979197 0.0003510509 1.800389e-01 3.012208e-01 1 114402760 114402883 124 - 1.795 1.802 0.023
ENSG00000197323 E011 16.822693 0.0353008486 1.226367e-02 3.416590e-02 1 114404326 114405409 1084 - 1.197 0.884 -1.145
ENSG00000197323 E012 161.094377 0.0002465741 1.995976e-04 9.621183e-04 1 114405410 114405759 350 - 2.114 2.053 -0.203
ENSG00000197323 E013 100.862489 0.0004018273 1.131310e-02 3.191185e-02 1 114406941 114407100 160 - 1.910 1.868 -0.141
ENSG00000197323 E014 61.608172 0.0074392624 2.985800e-01 4.400343e-01 1 114408677 114408740 64 - 1.691 1.688 -0.009
ENSG00000197323 E015 80.176647 0.0069031472 1.712598e-02 4.521903e-02 1 114410184 114410316 133 - 1.818 1.732 -0.290
ENSG00000197323 E016 3.875152 0.0039836834 1.158604e-01 2.140361e-01 1 114420380 114420451 72 - 0.646 0.395 -1.207
ENSG00000197323 E017 120.055321 0.0013010648 5.623323e-08 5.992022e-07 1 114421436 114421636 201 - 2.006 1.822 -0.621
ENSG00000197323 E018 107.020543 0.0003163175 2.894522e-09 3.941339e-08 1 114424591 114424755 165 - 1.960 1.748 -0.716
ENSG00000197323 E019 112.378377 0.0003032266 1.788135e-08 2.103557e-07 1 114425449 114425723 275 - 1.979 1.791 -0.630
ENSG00000197323 E020 60.264505 0.0005731874 5.610570e-07 4.916638e-06 1 114427177 114427294 118 - 1.720 1.465 -0.869
ENSG00000197323 E021 79.948143 0.0029793183 2.978232e-05 1.773826e-04 1 114427748 114427894 147 - 1.831 1.651 -0.608
ENSG00000197323 E022 70.940858 0.0003676630 2.413716e-06 1.844505e-05 1 114430798 114430912 115 - 1.784 1.581 -0.688
ENSG00000197323 E023 75.485589 0.0006176458 1.017049e-09 1.506818e-08 1 114433617 114433733 117 - 1.822 1.527 -1.001
ENSG00000197323 E024 90.298601 0.0004421866 4.091243e-16 1.625233e-14 1 114463104 114463236 133 - 1.908 1.507 -1.358
ENSG00000197323 E025 82.866867 0.0003584412 7.079465e-17 3.104591e-15 1 114463412 114463556 145 - 1.875 1.431 -1.509
ENSG00000197323 E026 61.498648 0.0004088883 3.799637e-08 4.194079e-07 1 114464270 114464388 119 - 1.732 1.443 -0.987
ENSG00000197323 E027 71.702777 0.0080055614 6.679290e-06 4.622362e-05 1 114510551 114511203 653 - 1.796 1.528 -0.910