ENSG00000197299

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355112 ENSG00000197299 HEK293_OSMI2_2hA HEK293_TMG_2hB BLM protein_coding protein_coding 15.36275 7.047741 21.5976 0.3140555 0.4019075 1.61426 3.7969551 0.9229665 6.48269043 0.30218117 0.31986535 2.7989192 0.21080833 0.1333000 0.30053333 0.16723333 8.263057e-02 4.395265e-06 FALSE TRUE
ENST00000560136 ENSG00000197299 HEK293_OSMI2_2hA HEK293_TMG_2hB BLM protein_coding processed_transcript 15.36275 7.047741 21.5976 0.3140555 0.4019075 1.61426 2.2206028 2.7357217 0.93615824 0.71524751 0.47534379 -1.5370320 0.21533333 0.3809333 0.04380000 -0.33713333 1.079245e-01 4.395265e-06 FALSE TRUE
ENST00000560821 ENSG00000197299 HEK293_OSMI2_2hA HEK293_TMG_2hB BLM protein_coding processed_transcript 15.36275 7.047741 21.5976 0.3140555 0.4019075 1.61426 0.3169626 0.6947440 0.07083553 0.52953375 0.07083553 -3.1240377 0.03702083 0.1002333 0.00340000 -0.09683333 3.148764e-01 4.395265e-06 FALSE TRUE
ENST00000681142 ENSG00000197299 HEK293_OSMI2_2hA HEK293_TMG_2hB BLM protein_coding protein_coding 15.36275 7.047741 21.5976 0.3140555 0.4019075 1.61426 5.9433543 0.1289482 10.46292653 0.12894818 0.66215897 6.2359739 0.27273750 0.0198000 0.48373333 0.46393333 1.498946e-03 4.395265e-06 FALSE TRUE
MSTRG.11546.2 ENSG00000197299 HEK293_OSMI2_2hA HEK293_TMG_2hB BLM protein_coding   15.36275 7.047741 21.5976 0.3140555 0.4019075 1.61426 1.6390756 1.9740738 1.76636277 0.09516305 0.38241598 -0.1595395 0.15387083 0.2800333 0.08173333 -0.19830000 4.395265e-06 4.395265e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197299 E001 0.9211837 0.0133704245 5.899383e-01 7.129228e-01 15 90717304 90717342 39 + 0.230 0.344 0.790
ENSG00000197299 E002 0.9254501 0.0132824116 5.897211e-01 7.127511e-01 15 90717343 90717345 3 + 0.230 0.344 0.789
ENSG00000197299 E003 6.3043468 0.0036235783 2.406538e-01 3.749302e-01 15 90717346 90717362 17 + 0.771 0.947 0.682
ENSG00000197299 E004 18.2032467 0.0072799478 3.887127e-02 8.894528e-02 15 90717363 90717393 31 + 1.166 1.380 0.752
ENSG00000197299 E005 21.3942876 0.0106326811 2.378709e-02 5.937669e-02 15 90717394 90717403 10 + 1.228 1.458 0.800
ENSG00000197299 E006 32.9408333 0.0030781094 1.253395e-04 6.382431e-04 15 90717404 90717440 37 + 1.382 1.667 0.976
ENSG00000197299 E007 11.8321202 0.0520643664 2.609819e-09 3.582511e-08 15 90724034 90724071 38 + 0.635 1.497 3.197
ENSG00000197299 E008 13.6088243 0.0023065510 5.565234e-15 1.902756e-13 15 90724072 90724143 72 + 0.771 1.520 2.711
ENSG00000197299 E009 26.4820946 0.0007297164 6.166667e-03 1.905056e-02 15 90747389 90747389 1 + 1.314 1.535 0.765
ENSG00000197299 E010 45.1760947 0.0004636077 9.045784e-01 9.432448e-01 15 90747390 90747490 101 + 1.598 1.631 0.111
ENSG00000197299 E011 2.6604006 0.0055536979 4.036496e-02 9.168760e-02 15 90747491 90747661 171 + 0.599 0.205 -2.297
ENSG00000197299 E012 194.6508329 0.0010493653 6.448562e-26 7.654516e-24 15 90749367 90750007 641 + 2.303 1.939 -1.217
ENSG00000197299 E013 55.6703197 0.0008106499 1.548893e-08 1.842711e-07 15 90750008 90750067 60 + 1.762 1.432 -1.128
ENSG00000197299 E014 89.7182614 0.0003453028 8.010786e-10 1.209451e-08 15 90751787 90751946 160 + 1.957 1.689 -0.906
ENSG00000197299 E015 86.7393416 0.0017616120 4.273533e-09 5.634407e-08 15 90754811 90754938 128 + 1.945 1.661 -0.960
ENSG00000197299 E016 1.8338466 0.1107205605 1.007492e-01 1.916041e-01 15 90759981 90760146 166 + 0.311 0.659 1.766
ENSG00000197299 E017 36.8338234 0.0005729036 2.829269e-05 1.692977e-04 15 90760147 90760150 4 + 1.581 1.296 -0.983
ENSG00000197299 E018 76.9906203 0.0004146998 1.102021e-06 9.067300e-06 15 90760151 90760279 129 + 1.882 1.661 -0.748
ENSG00000197299 E019 226.6206839 0.0002277218 3.016176e-13 8.001758e-12 15 90760594 90761255 662 + 2.339 2.154 -0.618
ENSG00000197299 E020 0.2214452 0.0385125145 1.391464e-01   15 90762364 90762395 32 + 0.000 0.206 11.620
ENSG00000197299 E021 0.1515154 0.0429248453 1.000000e+00   15 90762396 90762422 27 + 0.070 0.000 -9.414
ENSG00000197299 E022 102.9664873 0.0008926927 3.587659e-05 2.091553e-04 15 90762966 90763157 192 + 1.995 1.838 -0.528
ENSG00000197299 E023 86.6936851 0.0005198437 5.395738e-03 1.700333e-02 15 90765296 90765414 119 + 1.911 1.810 -0.341
ENSG00000197299 E024 89.1822004 0.0002916882 7.958957e-04 3.244982e-03 15 90766910 90767023 114 + 1.927 1.802 -0.421
ENSG00000197299 E025 76.6285396 0.0003365288 1.494056e-02 4.035249e-02 15 90769133 90769231 99 + 1.853 1.763 -0.306
ENSG00000197299 E026 102.5631296 0.0002842140 5.332943e-03 1.683710e-02 15 90769438 90769586 149 + 1.978 1.888 -0.301
ENSG00000197299 E027 87.3718840 0.0003615770 1.896610e-04 9.198143e-04 15 90782822 90782928 107 + 1.922 1.776 -0.492
ENSG00000197299 E028 113.4282498 0.0002638907 7.786662e-02 1.560520e-01 15 90784921 90785081 161 + 2.011 1.969 -0.141
ENSG00000197299 E029 13.1573488 0.0014271608 8.464490e-05 4.500497e-04 15 90789253 90790648 1396 + 0.948 1.346 1.429
ENSG00000197299 E030 138.2443208 0.0104964059 8.553574e-01 9.105743e-01 15 90790649 90790844 196 + 2.078 2.099 0.068
ENSG00000197299 E031 0.0000000       15 90793801 90794166 366 +      
ENSG00000197299 E032 132.1028380 0.0137992963 5.666750e-01 6.936071e-01 15 90794167 90794357 191 + 2.045 2.115 0.237
ENSG00000197299 E033 117.6249199 0.0003107532 2.517301e-02 6.223347e-02 15 90798190 90798337 148 + 1.984 2.091 0.359
ENSG00000197299 E034 166.3146678 0.0002616131 1.272804e-04 6.468745e-04 15 90803521 90803720 200 + 2.122 2.263 0.472
ENSG00000197299 E035 153.1094179 0.0031910907 4.486588e-06 3.228804e-05 15 90804167 90804359 193 + 2.065 2.273 0.697
ENSG00000197299 E036 3.2730750 0.0740809048 2.295077e-02 5.764377e-02 15 90808771 90808941 171 + 0.439 0.878 1.904
ENSG00000197299 E037 116.2337493 0.0033586422 1.034604e-10 1.821545e-09 15 90809137 90809259 123 + 1.908 2.214 1.025
ENSG00000197299 E038 158.6963792 0.0014956905 4.585582e-18 2.331521e-16 15 90811205 90811406 202 + 2.039 2.356 1.058
ENSG00000197299 E039 1.3942776 0.0105169553 1.736937e-01 2.929861e-01 15 90811678 90811800 123 + 0.273 0.534 1.467
ENSG00000197299 E040 1.2439081 0.1599315434 4.174201e-01 5.607701e-01 15 90811845 90811956 112 + 0.273 0.448 1.050
ENSG00000197299 E041 168.6115128 0.0078073660 6.918042e-09 8.784198e-08 15 90815102 90816166 1065 + 2.068 2.383 1.052