ENSG00000197291

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000587694 ENSG00000197291 HEK293_OSMI2_2hA HEK293_TMG_2hB RAMP2-AS1 lncRNA lncRNA 2.020106 2.089349 2.494397 0.1423029 0.2616108 0.2545208 0.2624261 0.1186514 0.2958216 0.03184444 0.07806824 1.2492234 0.13901667 0.0557000 0.1196667 6.396667e-02 0.40512332 0.04879157 TRUE FALSE
ENST00000589716 ENSG00000197291 HEK293_OSMI2_2hA HEK293_TMG_2hB RAMP2-AS1 lncRNA lncRNA 2.020106 2.089349 2.494397 0.1423029 0.2616108 0.2545208 0.5115865 0.7002366 0.8291043 0.08924687 0.09191058 0.2405505 0.24647917 0.3340000 0.3339333 -6.666667e-05 1.00000000 0.04879157 FALSE FALSE
ENST00000592195 ENSG00000197291 HEK293_OSMI2_2hA HEK293_TMG_2hB RAMP2-AS1 lncRNA lncRNA 2.020106 2.089349 2.494397 0.1423029 0.2616108 0.2545208 0.4542764 0.6370076 0.4214594 0.03533803 0.02947647 -0.5845580 0.21946250 0.3062000 0.1702333 -1.359667e-01 0.04879157 0.04879157 TRUE FALSE
ENST00000592670 ENSG00000197291 HEK293_OSMI2_2hA HEK293_TMG_2hB RAMP2-AS1 lncRNA lncRNA 2.020106 2.089349 2.494397 0.1423029 0.2616108 0.2545208 0.5751019 0.4644820 0.6555960 0.02858853 0.05544333 0.4882934 0.29091250 0.2259333 0.2639000 3.796667e-02 0.73139150 0.04879157 TRUE FALSE
MSTRG.14369.7 ENSG00000197291 HEK293_OSMI2_2hA HEK293_TMG_2hB RAMP2-AS1 lncRNA   2.020106 2.089349 2.494397 0.1423029 0.2616108 0.2545208 0.1732759 0.1689719 0.2924155 0.07312110 0.09885488 0.7567987 0.08059583 0.0782000 0.1122667 3.406667e-02 0.74913030 0.04879157 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197291 E001 2.775191 0.0056108720 5.713476e-01 0.6976480074 17 42753914 42753930 17 - 0.630 0.543 -0.391
ENSG00000197291 E002 5.283996 0.0033423540 7.314038e-01 0.8230681107 17 42753931 42753990 60 - 0.782 0.826 0.174
ENSG00000197291 E003 57.289344 0.0004799012 7.545531e-01 0.8401627791 17 42753991 42755213 1223 - 1.759 1.772 0.042
ENSG00000197291 E004 17.085525 0.0011808502 5.850620e-01 0.7088470536 17 42755214 42756110 897 - 1.275 1.232 -0.152
ENSG00000197291 E005 5.449971 0.0032916474 2.325384e-01 0.3654665245 17 42756111 42756198 88 - 0.877 0.723 -0.611
ENSG00000197291 E006 4.904881 0.0034957363 5.524880e-01 0.6817697512 17 42756199 42756261 63 - 0.803 0.723 -0.321
ENSG00000197291 E007 6.238568 0.0031630190 9.657448e-02 0.1852227199 17 42756262 42756379 118 - 0.955 0.751 -0.792
ENSG00000197291 E008 16.624272 0.0011698694 8.305904e-05 0.0004424996 17 42758295 42759022 728 - 1.057 1.377 1.133
ENSG00000197291 E009 17.786380 0.0012031437 7.593759e-01 0.8437375960 17 42759739 42759880 142 - 1.282 1.258 -0.083
ENSG00000197291 E010 16.776891 0.0012500617 4.573888e-01 0.5977088439 17 42760426 42760509 84 - 1.224 1.283 0.207
ENSG00000197291 E011 8.229451 0.0021469323 8.214434e-01 0.8874233336 17 42760510 42760513 4 - 0.955 0.980 0.092
ENSG00000197291 E012 7.212980 0.0244821284 8.883743e-01 0.9326312621 17 42760514 42760634 121 - 0.910 0.928 0.067
ENSG00000197291 E013 13.479916 0.0064253330 1.567033e-01 0.2707059920 17 42760635 42760711 77 - 1.232 1.104 -0.455
ENSG00000197291 E014 3.411442 0.0066692267 3.894106e-01 0.5335059649 17 42760712 42760879 168 - 0.713 0.585 -0.547
ENSG00000197291 E015 13.566603 0.0014157583 4.766267e-01 0.6152386530 17 42760880 42761257 378 - 1.192 1.130 -0.222