ENSG00000197256

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586659 ENSG00000197256 HEK293_OSMI2_2hA HEK293_TMG_2hB KANK2 protein_coding protein_coding 17.09719 19.82587 18.27521 2.288439 0.7208412 -0.1174346 6.062076 6.136055 7.754802 0.9923101 0.1083934 0.33728860 0.3546792 0.3059333 0.4257667 0.1198333 0.01409022 0.01409022 FALSE TRUE
ENST00000588724 ENSG00000197256 HEK293_OSMI2_2hA HEK293_TMG_2hB KANK2 protein_coding protein_coding 17.09719 19.82587 18.27521 2.288439 0.7208412 -0.1174346 3.177914 2.806547 2.767770 1.5657723 0.1953855 -0.02000035 0.1899250 0.1262333 0.1516333 0.0254000 0.83477035 0.01409022   FALSE
ENST00000588787 ENSG00000197256 HEK293_OSMI2_2hA HEK293_TMG_2hB KANK2 protein_coding protein_coding 17.09719 19.82587 18.27521 2.288439 0.7208412 -0.1174346 5.176038 8.533249 4.390279 0.1540080 0.5242929 -0.95718999 0.2946750 0.4444000 0.2388667 -0.2055333 0.02502595 0.01409022 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197256 E001 64.9031679 0.0030377953 5.186136e-07 4.572948e-06 19 11164270 11164369 100 - 1.636 1.918 0.953
ENSG00000197256 E002 546.5915532 0.0022454818 1.548283e-17 7.397669e-16 19 11164370 11165312 943 - 2.593 2.822 0.762
ENSG00000197256 E003 134.4793297 0.0007674987 1.922102e-05 1.197139e-04 19 11165313 11165429 117 - 2.030 2.191 0.539
ENSG00000197256 E004 371.8399397 0.0008318693 2.177086e-02 5.519997e-02 19 11165430 11166246 817 - 2.527 2.597 0.233
ENSG00000197256 E005 74.2143495 0.0003644561 6.782976e-02 1.397666e-01 19 11166247 11166283 37 - 1.899 1.845 -0.184
ENSG00000197256 E006 71.8191819 0.0003605499 4.850425e-02 1.065167e-01 19 11166284 11166308 25 - 1.890 1.828 -0.208
ENSG00000197256 E007 63.7471382 0.0003596567 5.107912e-02 1.110921e-01 19 11166309 11166323 15 - 1.841 1.776 -0.221
ENSG00000197256 E008 149.3334936 0.0002540220 5.302497e-02 1.145273e-01 19 11166324 11166557 234 - 2.192 2.156 -0.120
ENSG00000197256 E009 75.2797484 0.0012445508 1.321263e-01 2.370632e-01 19 11166558 11166611 54 - 1.903 1.858 -0.150
ENSG00000197256 E010 0.2934659 0.0301693823 9.552319e-01   19 11169676 11169876 201 - 0.124 0.121 -0.046
ENSG00000197256 E011 86.8226224 0.0003773622 6.878043e-01 7.900615e-01 19 11169877 11169966 90 - 1.937 1.942 0.016
ENSG00000197256 E012 121.3216617 0.0005633925 9.640934e-01 9.813587e-01 19 11170048 11170248 201 - 2.073 2.095 0.073
ENSG00000197256 E013 0.0000000       19 11170338 11170415 78 -      
ENSG00000197256 E014 98.3089843 0.0016310034 3.802770e-01 5.245623e-01 19 11172981 11173123 143 - 2.002 1.987 -0.049
ENSG00000197256 E015 114.6162363 0.0002819549 4.590606e-03 1.479319e-02 19 11174473 11174692 220 - 2.097 2.023 -0.245
ENSG00000197256 E016 73.4516959 0.0003773337 1.325788e-02 3.651950e-02 19 11175902 11175989 88 - 1.910 1.828 -0.275
ENSG00000197256 E017 132.4740855 0.0017163477 4.529980e-03 1.462768e-02 19 11176578 11176817 240 - 2.161 2.081 -0.267
ENSG00000197256 E018 65.7629958 0.0007984039 2.806625e-03 9.694364e-03 19 11178345 11178447 103 - 1.875 1.762 -0.382
ENSG00000197256 E019 3.5419652 0.0152758992 3.275304e-01 4.710009e-01 19 11178448 11178471 24 - 0.724 0.589 -0.574
ENSG00000197256 E020 63.1703759 0.0004518691 2.740089e-04 1.273994e-03 19 11178553 11178720 168 - 1.875 1.734 -0.476
ENSG00000197256 E021 0.0000000       19 11192432 11192830 399 -      
ENSG00000197256 E022 36.7818226 0.0008744271 2.497328e-01 3.856120e-01 19 11192831 11192880 50 - 1.602 1.555 -0.159
ENSG00000197256 E023 44.8784670 0.0005712512 2.230436e-01 3.540155e-01 19 11192881 11192937 57 - 1.681 1.637 -0.149
ENSG00000197256 E024 112.7318477 0.0015504036 4.553689e-02 1.011839e-01 19 11192938 11193440 503 - 2.080 2.027 -0.180
ENSG00000197256 E025 61.0834235 0.0004550311 2.092097e-02 5.342250e-02 19 11193441 11193636 196 - 1.833 1.749 -0.283
ENSG00000197256 E026 84.7565779 0.0004019009 4.116140e-06 2.984386e-05 19 11193637 11193936 300 - 2.008 1.851 -0.528
ENSG00000197256 E027 32.5580628 0.0006628028 1.887918e-04 9.159976e-04 19 11193937 11193945 9 - 1.623 1.415 -0.712
ENSG00000197256 E028 58.8222705 0.0014817784 2.051980e-03 7.387432e-03 19 11193946 11194042 97 - 1.839 1.711 -0.434
ENSG00000197256 E029 32.4668144 0.0032213983 8.101535e-01 8.795116e-01 19 11194475 11194503 29 - 1.519 1.524 0.015
ENSG00000197256 E030 42.3541356 0.0068913121 3.623194e-01 5.067026e-01 19 11194504 11194552 49 - 1.653 1.615 -0.128
ENSG00000197256 E031 36.3553259 0.0119290627 4.125149e-01 5.560699e-01 19 11194553 11194590 38 - 1.587 1.551 -0.125
ENSG00000197256 E032 0.0000000       19 11194792 11195192 401 -      
ENSG00000197256 E033 36.1784073 0.0016674017 4.584655e-01 5.987846e-01 19 11195556 11195621 66 - 1.528 1.593 0.223
ENSG00000197256 E034 26.9953791 0.0009293316 1.065662e-01 2.004863e-01 19 11195622 11195622 1 - 1.364 1.493 0.445
ENSG00000197256 E035 78.8131433 0.0095199644 3.382773e-02 7.941316e-02 19 11195623 11195820 198 - 1.951 1.849 -0.344
ENSG00000197256 E036 2.0702822 0.1446463108 4.254374e-01 5.683870e-01 19 11195821 11195881 61 - 0.562 0.415 -0.728
ENSG00000197256 E037 4.0181651 0.0045176377 8.274676e-01 8.915197e-01 19 11196050 11196057 8 - 0.666 0.713 0.198
ENSG00000197256 E038 9.6362336 0.0182534496 8.940623e-01 9.362679e-01 19 11196058 11196227 170 - 1.011 1.016 0.021
ENSG00000197256 E039 3.2496202 0.0081097777 1.681108e-02 4.451725e-02 19 11196228 11197183 956 - 0.775 0.416 -1.626
ENSG00000197256 E040 29.0051512 0.0006847206 1.762411e-04 8.621242e-04 19 11197485 11197577 93 - 1.580 1.358 -0.763
ENSG00000197256 E041 2.6454575 0.0610674896 7.913840e-01 8.665763e-01 19 11197707 11197791 85 - 0.520 0.590 0.321