ENSG00000197183

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326071 ENSG00000197183 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL4L protein_coding protein_coding 1.781639 3.107446 1.145377 0.6633347 0.09380807 -1.432001 0.53981549 1.5275188 0.14085217 0.31350691 0.14085217 -3.3493967 0.2235708 0.49460000 0.14460000 -0.350000000 0.14335753 0.04604073 FALSE  
ENST00000359676 ENSG00000197183 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL4L protein_coding protein_coding 1.781639 3.107446 1.145377 0.6633347 0.09380807 -1.432001 0.59021249 0.7242869 0.29731509 0.09398036 0.03289053 -1.2566253 0.3930500 0.25480000 0.25943333 0.004633333 0.96320233 0.04604073 FALSE  
ENST00000375677 ENSG00000197183 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL4L protein_coding protein_coding 1.781639 3.107446 1.145377 0.6633347 0.09380807 -1.432001 0.35389280 0.4424573 0.39893999 0.22182350 0.20189105 -0.1458924 0.1927500 0.11733333 0.32346667 0.206133333 0.75986286 0.04604073 FALSE  
ENST00000475781 ENSG00000197183 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL4L protein_coding nonsense_mediated_decay 1.781639 3.107446 1.145377 0.6633347 0.09380807 -1.432001 0.04230313 0.0000000 0.08427127 0.00000000 0.04864650 3.2368181 0.0317125 0.00000000 0.06743333 0.067433333 0.04604073 0.04604073 TRUE  
ENST00000621426 ENSG00000197183 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL4L protein_coding protein_coding 1.781639 3.107446 1.145377 0.6633347 0.09380807 -1.432001 0.16239603 0.2571382 0.21533602 0.10694763 0.05105010 -0.2455084 0.1119958 0.08233333 0.19623333 0.113900000 0.34240065 0.04604073 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197183 E001 100.4282592 0.012921020 0.524380236 0.6579088 20 32443059 32447816 4758 - 1.969 1.940 -0.098
ENSG00000197183 E002 9.2641256 0.007084859 0.327717628 0.4711950 20 32452236 32452437 202 - 1.042 0.925 -0.434
ENSG00000197183 E003 8.6385989 0.028027751 0.339962631 0.4838981 20 32452884 32453006 123 - 1.022 0.892 -0.483
ENSG00000197183 E004 13.1548839 0.001562047 0.632944259 0.7477326 20 32453304 32453495 192 - 1.131 1.079 -0.185
ENSG00000197183 E005 13.6302155 0.001475648 0.516620855 0.6511708 20 32453576 32453761 186 - 1.147 1.080 -0.241
ENSG00000197183 E006 0.7760110 0.016267441 0.170140556 0.2883680 20 32454015 32454084 70 - 0.398 0.153 -1.829
ENSG00000197183 E007 10.2562553 0.001843771 0.512964192 0.6478397 20 32456118 32456395 278 - 1.042 0.967 -0.277
ENSG00000197183 E008 16.9178613 0.008263933 0.008524452 0.0250988 20 32464780 32465117 338 - 0.955 1.237 1.023
ENSG00000197183 E009 2.3458341 0.302202781 0.480277558 0.6185688 20 32465118 32465134 17 - 0.301 0.516 1.191
ENSG00000197183 E010 17.7765380 0.029973481 0.217479806 0.3473513 20 32474601 32474742 142 - 1.080 1.241 0.577
ENSG00000197183 E011 5.1354296 0.018375448 0.162743509 0.2787285 20 32483362 32483582 221 - 0.544 0.772 0.972
ENSG00000197183 E012 0.0000000       20 32485537 32485764 228 -      
ENSG00000197183 E013 0.1482932 0.044592410 1.000000000   20 32486696 32486801 106 - 0.000 0.083 8.804
ENSG00000197183 E014 0.0000000       20 32509784 32509940 157 -      
ENSG00000197183 E015 4.2225578 0.004016956 0.141319910 0.2498426 20 32511347 32511456 110 - 0.813 0.598 -0.893
ENSG00000197183 E016 5.4996721 0.034874462 0.880020710 0.9270518 20 32520811 32520922 112 - 0.778 0.755 -0.095
ENSG00000197183 E017 2.7508868 0.010378555 0.665529870 0.7731977 20 32527758 32527764 7 - 0.477 0.549 0.343
ENSG00000197183 E018 4.4084242 0.003752148 0.257883617 0.3950610 20 32527765 32527913 149 - 0.544 0.719 0.759
ENSG00000197183 E019 0.0000000       20 32532317 32532416 100 -      
ENSG00000197183 E020 0.0000000       20 32533376 32533485 110 -      
ENSG00000197183 E021 0.0000000       20 32535441 32536397 957 -      
ENSG00000197183 E022 0.5514428 0.019741207 0.311308877 0.4537564 20 32548507 32548886 380 - 0.000 0.214 10.383
ENSG00000197183 E023 3.0036683 0.113874719 0.865059100 0.9170477 20 32584570 32585333 764 - 0.602 0.548 -0.242