ENSG00000197170

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356126 ENSG00000197170 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD12 protein_coding protein_coding 53.67628 29.34533 81.63167 1.080943 2.828317 1.475683 10.588331 5.759582 20.420440 1.2671118 0.4819519 1.824182 0.1851125 0.1945667 0.25053333 0.05596667 4.993979e-01 3.124707e-30 FALSE TRUE
ENST00000357146 ENSG00000197170 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD12 protein_coding protein_coding 53.67628 29.34533 81.63167 1.080943 2.828317 1.475683 3.043330 0.000000 7.749975 0.0000000 0.4452339 9.599908 0.0397625 0.0000000 0.09556667 0.09556667 3.124707e-30 3.124707e-30 FALSE TRUE
ENST00000584289 ENSG00000197170 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD12 protein_coding retained_intron 53.67628 29.34533 81.63167 1.080943 2.828317 1.475683 11.459514 4.296944 17.999326 1.0507575 0.2011406 2.064008 0.1947250 0.1480000 0.22093333 0.07293333 4.096629e-01 3.124707e-30 FALSE TRUE
MSTRG.14953.3 ENSG00000197170 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD12 protein_coding   53.67628 29.34533 81.63167 1.080943 2.828317 1.475683 4.149671 6.813946 1.153792 0.4592333 1.1537922 -2.551773 0.1218792 0.2333667 0.01386667 -0.21950000 2.139821e-02 3.124707e-30 FALSE TRUE
MSTRG.14953.4 ENSG00000197170 HEK293_OSMI2_2hA HEK293_TMG_2hB PSMD12 protein_coding   53.67628 29.34533 81.63167 1.080943 2.828317 1.475683 23.603794 12.410629 32.923344 1.0041454 2.8775481 1.406811 0.4384333 0.4216667 0.40206667 -0.01960000 8.592339e-01 3.124707e-30 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197170 E001 568.4132608 0.0180682695 7.154923e-02 1.459120e-01 17 67337916 67339802 1887 - 2.769 2.664 -0.349
ENSG00000197170 E002 254.9502340 0.0010474145 7.496235e-31 1.338491e-28 17 67339803 67340563 761 - 2.484 2.120 -1.218
ENSG00000197170 E003 155.0736051 0.0031094269 8.416797e-01 9.012349e-01 17 67340564 67340687 124 - 2.176 2.175 -0.004
ENSG00000197170 E004 226.5402816 0.0017144205 1.283479e-01 2.318486e-01 17 67340688 67340773 86 - 2.325 2.363 0.128
ENSG00000197170 E005 498.5938716 0.0002489657 1.047497e-10 1.842402e-09 17 67340774 67340974 201 - 2.641 2.743 0.340
ENSG00000197170 E006 374.5127925 0.0001578648 7.673089e-09 9.662614e-08 17 67340975 67341052 78 - 2.517 2.618 0.337
ENSG00000197170 E007 365.4111629 0.0001835604 3.344631e-09 4.499576e-08 17 67342186 67342263 78 - 2.504 2.609 0.352
ENSG00000197170 E008 2.8129587 0.0107565355 2.037824e-01 3.309414e-01 17 67342264 67342484 221 - 0.627 0.393 -1.134
ENSG00000197170 E009 539.8605217 0.0001228007 2.106419e-05 1.299641e-04 17 67344606 67344780 175 - 2.692 2.750 0.193
ENSG00000197170 E010 2.6185809 0.0058614932 5.536761e-01 6.827813e-01 17 67345612 67345744 133 - 0.580 0.472 -0.514
ENSG00000197170 E011 401.6889123 0.0001571284 9.715313e-07 8.081391e-06 17 67345745 67345857 113 - 2.555 2.636 0.271
ENSG00000197170 E012 386.3882774 0.0001345314 2.355147e-07 2.226759e-06 17 67347116 67347250 135 - 2.535 2.623 0.291
ENSG00000197170 E013 486.3869115 0.0024028626 9.823330e-01 9.929943e-01 17 67347336 67347485 150 - 2.672 2.656 -0.056
ENSG00000197170 E014 429.3271531 0.0001591676 6.059570e-06 4.233387e-05 17 67348550 67348654 105 - 2.644 2.548 -0.318
ENSG00000197170 E015 277.1671339 0.0001662901 2.347987e-04 1.111853e-03 17 67350229 67350257 29 - 2.455 2.359 -0.319
ENSG00000197170 E016 297.7063580 0.0001764831 2.512622e-04 1.180607e-03 17 67350258 67350298 41 - 2.485 2.393 -0.309
ENSG00000197170 E017 232.3890003 0.0001987210 2.878710e-04 1.330608e-03 17 67350299 67350336 38 - 2.381 2.278 -0.344
ENSG00000197170 E018 0.4783925 0.0213736147 9.019112e-01 9.415052e-01 17 67355341 67355422 82 - 0.156 0.174 0.187
ENSG00000197170 E019 0.1515154 0.0435189658 1.000000e+00   17 67357152 67357302 151 - 0.085 0.000 -8.043
ENSG00000197170 E020 342.5400167 0.0004160543 5.897278e-02 1.248753e-01 17 67357303 67357431 129 - 2.532 2.479 -0.177
ENSG00000197170 E021 0.4460135 0.0378045800 3.223427e-01 4.656616e-01 17 67357432 67357518 87 - 0.217 0.000 -9.628
ENSG00000197170 E022 199.6378391 0.0009857827 6.517861e-01 7.625922e-01 17 67357519 67357578 60 - 2.290 2.264 -0.086
ENSG00000197170 E023 2.0254201 0.2240503055 4.605491e-01 6.005696e-01 17 67361095 67361261 167 - 0.528 0.301 -1.246
ENSG00000197170 E024 2.1122026 0.0319625466 1.948421e-01 3.198108e-01 17 67362776 67362892 117 - 0.555 0.297 -1.401
ENSG00000197170 E025 257.1328302 0.0020093706 3.265760e-03 1.104895e-02 17 67366412 67366605 194 - 2.425 2.317 -0.359