ENSG00000197147

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330947 ENSG00000197147 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC8B protein_coding protein_coding 4.74499 1.075526 7.379831 0.2047611 0.1346217 2.767147 1.0240067 0.2293536 1.4502338 0.04651792 0.2928548 2.6089838 0.23898750 0.2395667 0.19543333 -0.04413333 9.234020e-01 4.3426e-11 FALSE TRUE
ENST00000449440 ENSG00000197147 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC8B protein_coding protein_coding 4.74499 1.075526 7.379831 0.2047611 0.1346217 2.767147 1.3299134 0.0000000 2.4266233 0.00000000 0.1734140 7.9287394 0.15798750 0.0000000 0.32833333 0.32833333 4.342600e-11 4.3426e-11 FALSE TRUE
MSTRG.1571.1 ENSG00000197147 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC8B protein_coding   4.74499 1.075526 7.379831 0.2047611 0.1346217 2.767147 0.4138828 0.2071474 0.6022851 0.20714738 0.1981924 1.4955291 0.08704167 0.2425000 0.08073333 -0.16176667 8.164689e-01 4.3426e-11 FALSE TRUE
MSTRG.1571.10 ENSG00000197147 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC8B protein_coding   4.74499 1.075526 7.379831 0.2047611 0.1346217 2.767147 0.2210768 0.0000000 0.4013060 0.00000000 0.1724970 5.3621402 0.02595000 0.0000000 0.05360000 0.05360000 1.036487e-01 4.3426e-11 FALSE TRUE
MSTRG.1571.2 ENSG00000197147 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC8B protein_coding   4.74499 1.075526 7.379831 0.2047611 0.1346217 2.767147 1.0605448 0.6390249 1.2366100 0.38724184 0.6814759 0.9416644 0.30279583 0.5179333 0.17006667 -0.34786667 6.994321e-01 4.3426e-11 FALSE TRUE
MSTRG.1571.6 ENSG00000197147 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC8B protein_coding   4.74499 1.075526 7.379831 0.2047611 0.1346217 2.767147 0.4063031 0.0000000 1.0003143 0.00000000 0.1055209 6.6586604 0.06087083 0.0000000 0.13616667 0.13616667 1.422544e-04 4.3426e-11 FALSE TRUE
MSTRG.1571.9 ENSG00000197147 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRC8B protein_coding   4.74499 1.075526 7.379831 0.2047611 0.1346217 2.767147 0.1675187 0.0000000 0.0000000 0.00000000 0.0000000 0.0000000 0.09045833 0.0000000 0.00000000 0.00000000   4.3426e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197147 E001 1.7714822 0.008020275 6.543422e-02 1.357681e-01 1 89524385 89524494 110 + 0.400 0.000 -11.409
ENSG00000197147 E002 1.0351233 0.011941277 2.233977e-01 3.544529e-01 1 89524495 89524587 93 + 0.275 0.000 -11.945
ENSG00000197147 E003 0.4375944 0.029500340 8.266449e-01 8.909171e-01 1 89524829 89524835 7 + 0.139 0.000 -10.727
ENSG00000197147 E004 0.5848434 0.025161355 5.445086e-01 6.749733e-01 1 89524836 89524839 4 + 0.177 0.000 -11.137
ENSG00000197147 E005 1.4790604 0.009007634 1.049130e-01 1.979687e-01 1 89524840 89524853 14 + 0.354 0.000 -12.394
ENSG00000197147 E006 2.5121074 0.005833850 2.116350e-02 5.394146e-02 1 89524854 89524882 29 + 0.497 0.000 -13.008
ENSG00000197147 E007 2.5121074 0.005833850 2.116350e-02 5.394146e-02 1 89524883 89524901 19 + 0.497 0.000 -13.008
ENSG00000197147 E008 6.4656082 0.002547403 4.297980e-02 9.650702e-02 1 89524902 89525022 121 + 0.781 0.546 -1.001
ENSG00000197147 E009 1.5416284 0.024979815 8.355622e-01 8.971601e-01 1 89525214 89525358 145 + 0.303 0.428 0.737
ENSG00000197147 E010 0.2934659 0.027862879 2.574203e-01   1 89526962 89526986 25 + 0.052 0.264 2.733
ENSG00000197147 E011 2.5704090 0.019011635 5.289102e-01 6.617823e-01 1 89549915 89549971 57 + 0.461 0.428 -0.170
ENSG00000197147 E012 1.1739533 0.013581009 1.731630e-01 2.923035e-01 1 89558711 89559036 326 + 0.303 0.000 -12.095
ENSG00000197147 E013 7.8140178 0.018226434 1.390907e-01 2.468205e-01 1 89568247 89568307 61 + 0.840 0.716 -0.497
ENSG00000197147 E014 10.6836587 0.001660588 9.727182e-03 2.809167e-02 1 89568439 89568493 55 + 0.970 0.716 -0.987
ENSG00000197147 E015 0.2924217 0.027416773 1.000000e+00   1 89572474 89572612 139 + 0.098 0.000 -10.194
ENSG00000197147 E016 7.1844636 0.002351879 4.545867e-03 1.466898e-02 1 89579591 89579591 1 + 0.833 0.428 -1.788
ENSG00000197147 E017 15.6871714 0.037174580 2.498018e-02 6.183342e-02 1 89579592 89579688 97 + 1.118 0.889 -0.846
ENSG00000197147 E018 242.8086275 0.000314436 1.427165e-24 1.497906e-22 1 89582625 89584789 2165 + 2.266 2.129 -0.459
ENSG00000197147 E019 0.0000000       1 89588313 89588368 56 +      
ENSG00000197147 E020 385.8135758 0.008755637 9.523994e-16 3.605700e-14 1 89592771 89597861 5091 + 2.381 2.701 1.067