ENSG00000197136

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355703 ENSG00000197136 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX3 protein_coding protein_coding 30.53209 38.68106 23.99635 3.140135 0.4577335 -0.6885842 4.808901 3.8125438 3.9776321 0.7879404 0.22352818 0.06099929 0.16355417 0.09713333 0.16583333 0.068700000 7.318417e-02 1.744842e-11 FALSE TRUE
ENST00000439247 ENSG00000197136 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX3 protein_coding retained_intron 30.53209 38.68106 23.99635 3.140135 0.4577335 -0.6885842 11.845380 21.8735174 6.1015769 1.8080503 0.15293107 -1.84022807 0.36195000 0.56720000 0.25433333 -0.312866667 1.744842e-11 1.744842e-11 FALSE TRUE
ENST00000530174 ENSG00000197136 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX3 protein_coding retained_intron 30.53209 38.68106 23.99635 3.140135 0.4577335 -0.6885842 1.342057 0.4311667 1.5350058 0.1352100 0.05973334 1.80821651 0.04828333 0.01183333 0.06393333 0.052100000 2.080185e-04 1.744842e-11 FALSE TRUE
MSTRG.5730.11 ENSG00000197136 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX3 protein_coding   30.53209 38.68106 23.99635 3.140135 0.4577335 -0.6885842 1.589193 1.0058607 0.5360812 0.5500105 0.53608120 -0.89551526 0.05613750 0.02413333 0.02160000 -0.002533333 6.537998e-01 1.744842e-11 FALSE TRUE
MSTRG.5730.6 ENSG00000197136 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX3 protein_coding   30.53209 38.68106 23.99635 3.140135 0.4577335 -0.6885842 2.126359 2.8201033 2.2034794 0.3766461 0.22049501 -0.35453881 0.07123333 0.07246667 0.09176667 0.019300000 4.340733e-01 1.744842e-11 FALSE TRUE
MSTRG.5730.7 ENSG00000197136 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX3 protein_coding   30.53209 38.68106 23.99635 3.140135 0.4577335 -0.6885842 1.640315 2.2900759 2.2496424 0.5111457 0.70433731 -0.02558699 0.05518750 0.06150000 0.09430000 0.032800000 7.089375e-01 1.744842e-11 TRUE TRUE
MSTRG.5730.8 ENSG00000197136 HEK293_OSMI2_2hA HEK293_TMG_2hB PCNX3 protein_coding   30.53209 38.68106 23.99635 3.140135 0.4577335 -0.6885842 4.791084 4.8347060 4.7686344 0.6948509 0.27404377 -0.01981072 0.16237917 0.12476667 0.19860000 0.073833333 3.562191e-02 1.744842e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197136 E001 0.4762024 0.2048562566 4.277489e-01 5.705847e-01 11 65614370 65614394 25 + 0.247 0.106 -1.470
ENSG00000197136 E002 5.0071652 0.0039258470 3.386285e-02 7.948180e-02 11 65615339 65615402 64 + 0.898 0.635 -1.057
ENSG00000197136 E003 6.3079564 0.1099052203 9.291397e-03 2.701310e-02 11 65615403 65615530 128 + 1.055 0.622 -1.697
ENSG00000197136 E004 5.6917781 0.0680761855 1.295814e-02 3.581311e-02 11 65615531 65615612 82 + 0.992 0.616 -1.495
ENSG00000197136 E005 7.3688979 0.0191189860 1.277047e-02 3.537443e-02 11 65615613 65615775 163 + 1.055 0.759 -1.126
ENSG00000197136 E006 48.5638544 0.0039787059 1.736747e-06 1.369425e-05 11 65615776 65615997 222 + 1.811 1.561 -0.849
ENSG00000197136 E007 38.7040778 0.0009844896 1.513134e-03 5.678790e-03 11 65615998 65616313 316 + 1.665 1.509 -0.534
ENSG00000197136 E008 13.4613580 0.0013608795 3.461380e-03 1.161521e-02 11 65616314 65616326 13 + 1.271 1.028 -0.867
ENSG00000197136 E009 11.7275454 0.0014581962 1.726653e-03 6.366843e-03 11 65616327 65616327 1 + 1.233 0.955 -1.007
ENSG00000197136 E010 17.5712027 0.0015400390 3.559293e-05 2.077126e-04 11 65616328 65616335 8 + 1.414 1.101 -1.102
ENSG00000197136 E011 27.5543741 0.0036954999 8.749774e-05 4.632808e-04 11 65616336 65616354 19 + 1.573 1.321 -0.868
ENSG00000197136 E012 31.4489183 0.0034758667 3.834953e-03 1.267821e-02 11 65616355 65616364 10 + 1.586 1.419 -0.575
ENSG00000197136 E013 50.1725284 0.0004701324 6.755118e-06 4.670173e-05 11 65616365 65616392 28 + 1.800 1.602 -0.673
ENSG00000197136 E014 58.1533758 0.0004004862 6.188283e-06 4.315670e-05 11 65616393 65616414 22 + 1.857 1.673 -0.621
ENSG00000197136 E015 81.2591674 0.0003321517 2.863947e-10 4.676590e-09 11 65616415 65616464 50 + 2.021 1.799 -0.748
ENSG00000197136 E016 141.5933280 0.0011925356 2.271205e-13 6.140617e-12 11 65616824 65617011 188 + 2.260 2.041 -0.734
ENSG00000197136 E017 103.7335544 0.0002912999 1.529328e-05 9.741004e-05 11 65617250 65617349 100 + 2.076 1.950 -0.423
ENSG00000197136 E018 74.7792114 0.0003590716 5.465661e-05 3.049936e-04 11 65617470 65617509 40 + 1.941 1.801 -0.473
ENSG00000197136 E019 104.7223843 0.0003606053 2.174615e-08 2.518489e-07 11 65617611 65617706 96 + 2.102 1.931 -0.573
ENSG00000197136 E020 503.1187588 0.0006608340 8.037640e-13 2.004617e-11 11 65617940 65619067 1128 + 2.747 2.638 -0.365
ENSG00000197136 E021 93.0852420 0.0003318144 1.179692e-01 2.170219e-01 11 65619537 65619660 124 + 1.971 1.938 -0.109
ENSG00000197136 E022 32.9721208 0.0021165326 8.537378e-01 9.094941e-01 11 65619754 65619756 3 + 1.485 1.524 0.133
ENSG00000197136 E023 86.3283935 0.0035291259 1.400971e-01 2.481587e-01 11 65619757 65619857 101 + 1.941 1.902 -0.131
ENSG00000197136 E024 82.4597989 0.0067591532 3.895102e-03 1.284985e-02 11 65619858 65619932 75 + 1.974 1.848 -0.424
ENSG00000197136 E025 126.1281173 0.0061668505 1.632900e-02 4.345265e-02 11 65620339 65620429 91 + 2.135 2.051 -0.281
ENSG00000197136 E026 163.6169095 0.0039439870 1.507669e-02 4.066276e-02 11 65620831 65620966 136 + 2.239 2.171 -0.226
ENSG00000197136 E027 40.1345778 0.0200294385 1.213217e-02 3.384982e-02 11 65622206 65622223 18 + 1.700 1.519 -0.616
ENSG00000197136 E028 50.3891849 0.0060955579 8.391457e-03 2.476842e-02 11 65622224 65622244 21 + 1.767 1.635 -0.450
ENSG00000197136 E029 135.0511429 0.0053831989 1.656693e-01 2.825719e-01 11 65622245 65622366 122 + 2.132 2.102 -0.101
ENSG00000197136 E030 138.9357951 0.0010927185 1.793935e-01 3.003584e-01 11 65623491 65623644 154 + 2.134 2.116 -0.058
ENSG00000197136 E031 87.2532598 0.0040981171 3.816682e-02 8.767009e-02 11 65623929 65623961 33 + 1.967 1.896 -0.239
ENSG00000197136 E032 201.2568763 0.0025564488 1.517558e-04 7.547779e-04 11 65624195 65624366 172 + 2.346 2.246 -0.336
ENSG00000197136 E033 166.1645326 0.0002473643 2.281898e-08 2.631956e-07 11 65624471 65624581 111 + 2.278 2.147 -0.438
ENSG00000197136 E034 129.3761550 0.0002374453 1.408970e-04 7.074050e-04 11 65624925 65625016 92 + 2.150 2.056 -0.316
ENSG00000197136 E035 1.4779371 0.0099816875 6.678316e-01 7.749772e-01 11 65625127 65625170 44 + 0.333 0.424 0.524
ENSG00000197136 E036 135.5825789 0.0002328334 3.276863e-05 1.931524e-04 11 65625171 65625280 110 + 2.177 2.074 -0.342
ENSG00000197136 E037 126.1326040 0.0018017702 9.643405e-03 2.788756e-02 11 65625405 65625510 106 + 2.129 2.059 -0.233
ENSG00000197136 E038 129.1769649 0.0012990380 3.526439e-01 4.968923e-01 11 65625652 65625744 93 + 2.099 2.093 -0.020
ENSG00000197136 E039 176.2625242 0.0026079461 9.565034e-01 9.767375e-01 11 65625904 65626054 151 + 2.213 2.241 0.092
ENSG00000197136 E040 22.7833835 0.0105664415 2.573099e-09 3.535180e-08 11 65626055 65626779 725 + 1.608 1.117 -1.710
ENSG00000197136 E041 11.0517811 0.0235314267 1.199669e-02 3.352317e-02 11 65626853 65626903 51 + 1.203 0.933 -0.981
ENSG00000197136 E042 165.6799546 0.0023873742 7.421873e-01 8.311570e-01 11 65626904 65627048 145 + 2.192 2.210 0.059
ENSG00000197136 E043 176.2662258 0.0011582042 5.842071e-02 1.239215e-01 11 65627405 65627582 178 + 2.244 2.214 -0.101
ENSG00000197136 E044 183.8294767 0.0051349048 1.721318e-01 2.909681e-01 11 65628595 65628703 109 + 2.259 2.238 -0.071
ENSG00000197136 E045 238.0225975 0.0051658703 2.194303e-02 5.555651e-02 11 65628819 65628948 130 + 2.398 2.335 -0.207
ENSG00000197136 E046 178.2426599 0.0016517664 1.465205e-02 3.971025e-02 11 65629357 65629415 59 + 2.266 2.213 -0.175
ENSG00000197136 E047 334.1451976 0.0001819714 1.025395e-02 2.939074e-02 11 65629520 65629735 216 + 2.520 2.495 -0.084
ENSG00000197136 E048 214.5381094 0.0017899151 6.834874e-01 7.866815e-01 11 65630351 65630410 60 + 2.289 2.331 0.139
ENSG00000197136 E049 287.5008497 0.0001986612 2.573559e-01 3.944603e-01 11 65630411 65630604 194 + 2.406 2.459 0.174
ENSG00000197136 E050 6.6931319 0.0062856548 9.625018e-01 9.803549e-01 11 65634079 65634125 47 + 0.854 0.882 0.110
ENSG00000197136 E051 295.2618756 0.0001782801 3.104554e-02 7.400607e-02 11 65634126 65634356 231 + 2.402 2.476 0.248
ENSG00000197136 E052 207.3166282 0.0002104335 1.166267e-04 5.984125e-04 11 65634538 65634641 104 + 2.211 2.340 0.430
ENSG00000197136 E053 235.5380709 0.0002191571 1.125845e-05 7.391972e-05 11 65634973 65635120 148 + 2.262 2.399 0.456
ENSG00000197136 E054 323.2264600 0.0001746577 1.807561e-15 6.605653e-14 11 65635218 65635448 231 + 2.354 2.553 0.665
ENSG00000197136 E055 323.5702051 0.0001614253 1.780727e-18 9.510949e-17 11 65635529 65635803 275 + 2.339 2.557 0.726
ENSG00000197136 E056 23.6348920 0.0008396740 5.483957e-01 6.782431e-01 11 65635951 65636031 81 + 1.329 1.398 0.241
ENSG00000197136 E057 252.8922015 0.0005234527 1.148719e-14 3.744347e-13 11 65636174 65636307 134 + 2.226 2.456 0.769
ENSG00000197136 E058 482.4456266 0.0028505874 1.076344e-16 4.609182e-15 11 65636391 65636689 299 + 2.466 2.755 0.961
ENSG00000197136 E059 985.4735707 0.0089958940 4.592466e-09 6.029307e-08 11 65636766 65637590 825 + 2.774 3.067 0.976