ENSG00000197056

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359858 ENSG00000197056 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM1 protein_coding protein_coding 8.58544 1.956085 14.94954 0.1647488 0.9187538 2.927668 1.8076805 0.2528968 2.8154395 0.25289680 0.7108601 3.4259068 0.18454167 0.12996667 0.19336667 0.06340000 4.103420e-01 1.802979e-06 FALSE TRUE
ENST00000373329 ENSG00000197056 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM1 protein_coding processed_transcript 8.58544 1.956085 14.94954 0.1647488 0.9187538 2.927668 1.6457204 0.3994668 3.1386085 0.20784166 1.2191067 2.9428960 0.19240417 0.21310000 0.20193333 -0.01116667 9.605030e-01 1.802979e-06 FALSE TRUE
ENST00000463393 ENSG00000197056 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM1 protein_coding processed_transcript 8.58544 1.956085 14.94954 0.1647488 0.9187538 2.927668 0.5834963 0.0000000 1.2641458 0.00000000 0.4866427 6.9933865 0.05715000 0.00000000 0.08393333 0.08393333 2.800493e-02 1.802979e-06 FALSE FALSE
ENST00000466390 ENSG00000197056 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM1 protein_coding processed_transcript 8.58544 1.956085 14.94954 0.1647488 0.9187538 2.927668 0.4058387 0.1545688 0.6972857 0.15456877 0.2203399 2.1036026 0.05060833 0.06880000 0.04526667 -0.02353333 8.125180e-01 1.802979e-06   FALSE
MSTRG.813.12 ENSG00000197056 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM1 protein_coding   8.58544 1.956085 14.94954 0.1647488 0.9187538 2.927668 0.6961078 0.5717934 0.7199065 0.05863128 0.7199065 0.3272046 0.14960000 0.29140000 0.05273333 -0.23866667 7.494617e-02 1.802979e-06 FALSE TRUE
MSTRG.813.13 ENSG00000197056 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM1 protein_coding   8.58544 1.956085 14.94954 0.1647488 0.9187538 2.927668 0.7151520 0.0000000 1.8232607 0.00000000 0.4391539 7.5182682 0.07146250 0.00000000 0.12626667 0.12626667 6.661204e-04 1.802979e-06 TRUE TRUE
MSTRG.813.6 ENSG00000197056 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM1 protein_coding   8.58544 1.956085 14.94954 0.1647488 0.9187538 2.927668 0.7069119 0.0000000 1.6209371 0.00000000 0.2051991 7.3495574 0.06609583 0.00000000 0.10766667 0.10766667 1.802979e-06 1.802979e-06 FALSE TRUE
MSTRG.813.7 ENSG00000197056 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM1 protein_coding   8.58544 1.956085 14.94954 0.1647488 0.9187538 2.927668 1.0302893 0.2519847 1.6112801 0.07505764 0.4066814 2.6295790 0.10734583 0.12543333 0.10536667 -0.02006667 9.265474e-01 1.802979e-06 FALSE TRUE
MSTRG.813.8 ENSG00000197056 HEK293_OSMI2_2hA HEK293_TMG_2hB ZMYM1 protein_coding   8.58544 1.956085 14.94954 0.1647488 0.9187538 2.927668 0.1074229 0.1357153 0.0000000 0.13571531 0.0000000 -3.8650806 0.01597917 0.08096667 0.00000000 -0.08096667 4.170260e-01 1.802979e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000197056 E001 0.8825612 0.1764222271 0.1603546869 0.2756113911 1 35032172 35032440 269 + 0.126 0.467 2.526
ENSG00000197056 E002 0.2214452 0.0379943901 0.0486737540   1 35036806 35036928 123 + 0.000 0.289 29.567
ENSG00000197056 E003 0.1472490 0.0437274523 0.7890410855   1 35059786 35059925 140 + 0.046 0.000 -23.688
ENSG00000197056 E004 0.1472490 0.0437274523 0.7890410855   1 35078994 35079219 226 + 0.046 0.000 -23.688
ENSG00000197056 E005 0.0000000       1 35079327 35079355 29 +      
ENSG00000197056 E006 0.6664265 0.0163273841 0.0687541229 0.1413040098 1 35079356 35079367 12 + 0.088 0.461 3.075
ENSG00000197056 E007 0.8179419 0.0155197924 0.1237041835 0.2252276405 1 35079368 35079373 6 + 0.126 0.461 2.490
ENSG00000197056 E008 1.4415071 0.0114113895 0.1090648271 0.2041679855 1 35079374 35079378 5 + 0.223 0.584 2.075
ENSG00000197056 E009 1.7318525 0.0575504585 0.2064221480 0.3342312306 1 35079379 35079380 2 + 0.278 0.584 1.663
ENSG00000197056 E010 1.8791015 0.0085543500 0.2441765334 0.3791153014 1 35079381 35079381 1 + 0.303 0.584 1.490
ENSG00000197056 E011 2.2425103 0.0165320303 0.0293842570 0.0707429069 1 35079382 35079384 3 + 0.303 0.758 2.228
ENSG00000197056 E012 2.2425103 0.0165320303 0.0293842570 0.0707429069 1 35079385 35079385 1 + 0.303 0.758 2.228
ENSG00000197056 E013 2.3876830 0.0455395064 0.0478268738 0.1053172978 1 35079386 35079386 1 + 0.326 0.758 2.079
ENSG00000197056 E014 3.2628718 0.0746147198 0.1905531312 0.3144531041 1 35079387 35079390 4 + 0.446 0.759 1.405
ENSG00000197056 E015 20.4131908 0.0009595978 0.3950296452 0.5388699060 1 35079391 35079442 52 + 1.136 1.299 0.577
ENSG00000197056 E016 1.9420258 0.1182653482 0.1643239231 0.2808031016 1 35093239 35093319 81 + 0.391 0.000 -27.393
ENSG00000197056 E017 8.6321096 0.0871009735 0.7344323893 0.8253806406 1 35093320 35093325 6 + 0.806 0.936 0.502
ENSG00000197056 E018 10.7067363 0.0318156961 0.8195210811 0.8860318117 1 35093326 35093343 18 + 0.901 0.934 0.125
ENSG00000197056 E019 13.6113857 0.0013667248 0.4536099081 0.5943606227 1 35093344 35093393 50 + 1.003 0.978 -0.095
ENSG00000197056 E020 14.1261830 0.0033253826 0.8352021357 0.8968792421 1 35093394 35093441 48 + 1.008 1.057 0.177
ENSG00000197056 E021 28.8844133 0.0006532497 0.8561453015 0.9110602972 1 35093914 35094009 96 + 1.295 1.357 0.215
ENSG00000197056 E022 28.7769201 0.0037630598 0.5796555855 0.7045004761 1 35094010 35094083 74 + 1.295 1.320 0.085
ENSG00000197056 E023 30.5766242 0.0006891246 0.6811954352 0.7849448723 1 35095819 35095891 73 + 1.309 1.423 0.396
ENSG00000197056 E024 52.1460319 0.0004569381 0.3017281712 0.4435421676 1 35097317 35097566 250 + 1.549 1.556 0.023
ENSG00000197056 E025 3.5711907 0.0052903197 0.1607412482 0.2760879368 1 35097567 35097594 28 + 0.554 0.289 -1.448
ENSG00000197056 E026 9.4327317 0.0019010490 0.0258393291 0.0636076792 1 35099351 35099445 95 + 0.797 1.153 1.328
ENSG00000197056 E027 1.0287806 0.0121976511 0.3833352125 0.5275201086 1 35104243 35104294 52 + 0.252 0.000 -26.495
ENSG00000197056 E028 38.9472987 0.0009725504 0.0726062160 0.1476844016 1 35104295 35104469 175 + 1.433 1.357 -0.264
ENSG00000197056 E029 58.0457535 0.0332432985 0.2669373170 0.4052088837 1 35104557 35104769 213 + 1.597 1.567 -0.101
ENSG00000197056 E030 56.8163172 0.0007049310 0.0001485133 0.0007405025 1 35110294 35110447 154 + 1.607 1.391 -0.740
ENSG00000197056 E031 14.8460199 0.0012290179 0.2965712444 0.4378026894 1 35111772 35111775 4 + 1.040 0.978 -0.231
ENSG00000197056 E032 19.7197635 0.0009683076 0.0701477613 0.1436151353 1 35111776 35111807 32 + 1.163 1.019 -0.522
ENSG00000197056 E033 20.0594292 0.0009523680 0.0115545169 0.0324763146 1 35111808 35111824 17 + 1.180 0.932 -0.902
ENSG00000197056 E034 39.0760867 0.0005863070 0.0005564502 0.0023715510 1 35111825 35111912 88 + 1.454 1.207 -0.862
ENSG00000197056 E035 36.0988370 0.0005933130 0.0024973724 0.0087554769 1 35112087 35112130 44 + 1.419 1.207 -0.739
ENSG00000197056 E036 59.5312267 0.0004463180 0.0012150547 0.0046915961 1 35112977 35113181 205 + 1.624 1.467 -0.534
ENSG00000197056 E037 39.9348818 0.0005582737 0.0750177614 0.1515595424 1 35113182 35113296 115 + 1.446 1.374 -0.247
ENSG00000197056 E038 426.7287694 0.0164927963 0.0013449118 0.0051262401 1 35113297 35115859 2563 + 2.421 2.630 0.697